Jun Cao

Jiangnan University

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Taiqun Yang

Jiangnan University

Chenkai Zheng

Air Force Medical University

Guoqing Chen

Jiangnan University

Kun Chen

Tongji Hospital

Longyao Ma

Jiangnan University

Chaoqun Ma

Jiangnan University

Zehao Chen

Jiangnan University

Hui Gao

Guangxi University of Chinese Medicine

Lei Li

Harbin Engineering University

Anqi Hu

Sun Yat-sen University Cancer Center

Cooperative Institutions

Jiangnan University

Ningxia Medical University

Chinese Academy of Sciences

Yunnan University

Hainan University

University of Chinese Academy of Sciences

Light Industry Hangzhou Electromechanical Design Institute

Hainan Tropical Ocean University

Huazhong University of Science and Technology

Affiliated Hospital of Zunyi Medical College

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Sers Substrate Based on Cof@Ag for Detecting Amoxicillin in Honey and Lake Water

Kun Chen Chaoqun Ma Guoqing Chen Taiqun Yang Lei Li

This study presents the design of a Surface-enhanced Raman scattering (SERS) substrate, COF@Ag, for the sensitive detection of Amoxicillin (AMX) in lake water and honey. Furthermore, the study investigates the role of covalent organic frameworks (COFs) in SERS detection. The characterization results demonstrate the capability of COFs to efficiently enrich Ag nanoparticles (AgNPs), resulting in a more concentrated distribution of hotspots and an enhanced electromagnetic field on the substrate. By employing density functional theory (DFT) simulation, the frontier electronic orbitals of COFs and AMX were analyzed, and the chemical bonds and weak interactions in the system were examined using the Interaction Region Indicator (IRI) method to propose potential enhancement mechanisms. In aqueous solutions, the linear range is 1μg/L-30μg/L, with a limit of detection (LOD) 0.279μg/L. In lake water, the linear range span from 100μg/L to 500μg/L, with a detection limit of 8.246μg/L. For honey, the linear range extend from 20ng/g to 100ng/g, with a detection limit of 2.470ng/g. This method holds key significance in facilitating the rapid detection of amoxicillin and advancing the application of COFs in SERS.

10.2139/ssrn.4659468

Cite

Citations (0)

The Role of Akt in Liver Regeneration

Kunming Yike Daxue xuebao (2009)

Jun Cao

Wortmannin

Liver Regeneration

Source

Cite

Citations (0)

Effect of Diabetes on Vascular Calcification in Diabetic Rat

Journal of Ningxia Medical University (2009)

Jun Cao

Objective To explore the possible mechanism which was involved in the regulatory action of diabetes in vascular calcification.Methods Rat vascular calcific model were induced by vitamin D3 intramuscular injection and oral nicotine;diabetic rat model were induced by streptozocin(STZ) intraperitoneal injection for once.The total aorta Ca2+ content in aorta was measured by atom absorptive spectrophotography;the alkaline phosphatase(ALP) activity in plasma and aorta;and the levels of osteocalcin(OC),tumor necrosis factor(TNF) in plasma and aorta were determined by radioimmunoassay.Results Many black granules among the smooth muscle cells and its matrix in calcified aorta by Von Kossa staining in VDN group was observed;1.98-fold,2.83-fold,84.12% increase Calcium,ALP and OC were observed in VDN group and more than that in control group,respectively;TNF level of aortic was significantly increased(P0.01).The calcification in aorta was significantly promoted by diabetic rat model induced by streptozocin(STZ).When diabetes was happening,the total aorta Ca2+ contents,ALP activity,and OC levels were more respectively than those in the rats with vascular calcification.Diabetes treatment significantly increased TNF level(P 0.01).Conclusion Results indicated that diabetes can significantly promote the calcification in aorta partly through the cooperation with TNF system in circulation and vascular tissues.

Streptozocin

Intraperitoneal injection

Source

Cite

Citations (0)

Sers Substrate Based on Cofs@Ag for Rapid Detection of Pefloxacin

Kun Chen Chaoqun Ma Guoqing Chen Taiqun Yang Hui Gao

Pefloxacin

10.2139/ssrn.5062590

Cite

Citations (0)

Sers Substrate Based on Cofs@Ag for Rapid Detection of Pefloxacin

Kun Chen Chaoqun Ma Guoqing Chen Taiqun Yang Hui Gao

Pefloxacin

10.2139/ssrn.5072852

Cite

Citations (0)

SERS substrate based on COFs@Ag for rapid detection of pefloxacin

Research Square (Research Square) (2025)

Kun Chen Chaoqun Ma Guoqing Chen Taiqun Yang Hui Gao

Abstract The detection of pefloxacin in milk is of significant importance for food safety. Traditional methods for detecting pefloxacin often rely on techniques such as high-performance liquid chromatography (HPLC), which are complex and time-consuming. This article introduces a surface-enhanced Raman scattering (SERS) substrate based on a composite of covalent organic frameworks (COFs) and silver nanoparticles (AgNPs) for the rapid detection of pefloxacin in milk. After testing pefloxacin (PEF) in both water and milk, the detection limits were calculated to be 6.31 µg/L for water and 82 µg/L for milk, with correlation coefficients of 0.991 and 0.998, respectively. Furthermore, the average recovery rate of pefloxacin in milk ranged from 96.25–106.17%, with a relative standard deviation (RSD) of 4.32–8.88%. This work offers a simple and rapid method for detecting pefloxacin in milk.

Pefloxacin

10.21203/rs.3.rs-6055076/v1

Cite

Citations (0)

Effects of Epigallocatechingallate on Vascular Smooth Muscle Cells Calcification in Rats

Jun Cao

Objective To explore the effects of epigallocatechingallate(EGCG) on vascular calcification.Methods Calcific vascular smooth muscular cells(VSMCs) were induced by β-glycerophosphate in rats.Rats were invided into four groups:the control,the calcification,EGCG and EGCG intervention groups(10-7,10-6,10-5 and 10-4 mol·L-1 subgroups).Von Kossa staining,the Ca2+ content and the alkaline phosphatase(ALP) activity in VSMCs were measured.Results Lots of gathered black granules were found among the smooth muscle cells and its matrix by Von Kossa staining in VSMCs calcifacation group;more Calcium contents and ALP activities were observed in calcification group than those in control group;after treated with EGCG 10-7~10-4mol·L-1,the calcification in VSMCs was also attenuated and the total Ca2+ content and ALP activity in VSMCs showed decrease and a concentration-dependent manner.Conclusion The results indicated that EGCG can significantly attenuate the VSMCs calcification.

Von Kossa stain

Cite

Citations (0)

Carrageenan-Reduced Silver Nanoparticles for Direct and Rapid SERS Detection of Sorbic Acid

Plasmonics (2024)

Jun Cao Guoqing Chen Chaoqun Ma Taiqun Yang Hui Gao

Sorbic acid

Carrageenan

Silver nanoparticle

10.1007/s11468-024-02598-6

Cite

Citations (0)

Role of Nitric Oxide in Exercise-induced Proteinuria in Rats

Academic Journal of Kunming Medical College (2009)

Jun Cao Hongjian Zhang

Objective To explore the role of nitric oxide in exercise-induced proteinuria in rats. Methods 40 male SD rats were divided randomly into four groups:Control,L-NAME,exercise,and L-NAME exercise.Basal (pretreatment of L-NAME) and posttreatment (just before exercise or 2 h after L-NAME administration) BP values were measured by a noninvasive tail-cuff method.Total urinary protein and creatinine levels were measured by spectrophotometric technique, and values are expressed as milligrams per milligram creatinine.we used the Sebia Hydragel Proteinurie kit to determine the type of proteinuria.Results 2 h after L-NAME administration, BP of rats were higher than Basal BP (P 0.05).Total urinary protein levels in exercise group were higher than in control group (P0.05).Comared with control and exercise group,total urinary protein levels were higher in L -NAME exercise group (P 0.05).The type of proteinuria was mixed-type proteinuria in exercise group and L-NAME exercise.Conlusion NOS inhibitor L-NAME can cause exercise-induced proteinuria in rats,and the mechanism is related to NO deficiency.

Basal (medicine)

Source

Cite

Citations (0)

SERS substrate based on COF@Ag for detecting amoxicillin in honey and lake water

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy (2024)

Kun Chen Chaoqun Ma Guoqing Chen Taiqun Yang Hui Gao

Linear range

10.1016/j.saa.2024.124165

Cite

Citations (2)