Azam Sadat Mousavi

Tehran University of Medical Sciences

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Setareh Akhavan

Imam Khomeini Hospital

Mitra Modares Gilani

Tehran University of Medical Sciences

Nadereh Behtash

Tehran University of Medical Sciences

Fatemeh Ghaemmaghami

Tehran University of Medical Sciences

Mojgan Karimi‐Zarchi

Shahid Sadoughi University of Medical Sciences and Health Services

Shahrzad Sheikhhasani

Imam Khomeini Hospital

Ramin Ayanzadeh

Atlanta Technical College

Mitra Modarres Gilani

Tehran University of Medical Sciences

Narges Zamani

Tehran University of Medical Sciences

Elahe Rezayof

Imam Khomeini Hospital

Cooperative Institutions

Tehran University of Medical Sciences

Imam Khomeini Hospital

University of Tehran

Shariati Hospital

Iran University of Medical Sciences

Shahid Sadoughi University of Medical Sciences and Health Services

Shahid Beheshti University of Medical Sciences

Arak University of Medical Sciences

Advanced Diagnostic and Interventional Radiology Research Center

Motamed Cancer Institute

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Diagnostic value of Pap smear compared with colposcopy in diagnosis of abnormal cases in women referred to gynecology clinic

DOAJ (DOAJ: Directory of Open Access Journals) (2017)

Fatemeh Mahmoudi Azam Sadat Mousavi Zeinab Mahmoodi Parvin Ghaffari

مقدمه: سرطان دهانه رحم، سومین سرطان شایع در زنان و بروز سالیانه آن بیش از 500 هزار مورد در دنیا و در آمریکا شایع‌ترین علت مرگ ناشی از سرطان ژنیکولوژی در سال 2011 بوده است. پیگیری پاپ‌اسمیرهای غیرطبیعی به کمک روشهای تشخیصی با حساسیت بالا، ایجاب میکند با بررسی ارزش تشخیصی پاپ اسمیر در مقایسه با کولپوسکوپی در تشخیص موارد غیر طبیعی و درمان به‌موقع از مرگ‌و‌میر ناشی از سرطان سرویکس کاست، لذا مطالعه حاضر با هدف بررسی ارزش تشخیصی پاپ‌ اسمیر در مقایسه با کولپوسکوپی در تشخیص موارد غیر‌ طبیعی دهانه رحم انجام گرفت. روش‌کار: این مطالعه توصیفی - مقطعی در سال 1394 بر روی 172 زن با پاپ ‌اسمیر غیر ‌طبیعی که به درمانگاه تخصصی زنان شهر یاسوج مراجعه کرده و مورد کولپوسکوپی قرار گرفته بودند، انجام گرفت. ابزار گردآوری دادهها چک ‌لیست ابزار گردآوری دادهها چک لیستی (مشخصات فردی و مامایی، جواب پاپ ‌اسمیر و بررسی کولپوسکوپی) و روش گردآوری دادهها به صورت معاینه و مشاهده بود. تجزیه و تحلیل دادهها با استفاده از نرم‌افزار آماری SPSS‌ (نسخه 19) و آزمون‌ کای ‌دو انجام شد. میزان p کمتر از 05/0 معنی‌دار در نظر گرفته شد. یافته‌ها: در این مطالعه 55 نفر (31%) دارای کولپوسکوپی غیر ‌نرمال و 1/22% از موارد غیر‌نرمال، استووایت بودند. 117 مورد (0/68%) از پاپ‌اسمیرهای غیر‌طبیعی از طریق انجام کولپوسکوپی نرمال تشخیص داده شد که بیانگر میزان انطباق پاپ‌اسمیر و کولپوسکوپی با ضریب توافق 30% بود (032/0=p). بیشترین انطباق کولپوسکوپی با پاپ‌اسمیر در ضایعه با درجه بالا (CIN3) به‌دست آمد. کمترین تطبیق در مواردی بود که پاپ‌اسمیر ضایعه‌ای با درجه خفیف (CIN1 ,CIN2) را نشان داد. حساسیت تشخیصی تست کولپوسکوپی 93% به‌دست آمد، بنابراین دقت تشخیص کولپوسکوپی (3/54%) از پاپ‌اسمیر (26/41%) بالاتر بود. نتیجه‌گیری: کولپوسکوپی در مقایسه با پاپ‌اسمیر در یافتن مراحل اولیه سرطان دهانه‌ رحم از ارزش تشخیصی و کارایی بیشتری برخوردار است. بیشترین انطباق کولپوسکوپی با پاپ‌اسمیر در ضایعه با درجه بالا (CIN3) به‌دست آمد.

10.22038/ijogi.2017.10158

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#139 Uterine involvement in epithelial ovarian cancer and its risk factors

Mitra Modares Gilani Narges Zamani Azam Sadat Mousavi Setare Akhavan Shahrzad Sheikhhasani

Introduction/Background

Epithelial ovarian cancer (EOC) is an extremely aggressive and lethal carcinoma. Specific data that identify high-risk groups with uterine involvement are not available. Thus, this study aimed to evaluate a gross number of women with EOC to obtain the frequency of uterine involvement and its risk factors.

Methodology

This retrospective observational study was conducted on 1900 histologically confirmed EOC women, diagnosed and treated in our tertiary hospital from March 2009 to September 2020. Data including their demographic, medical and pathological findings were collected.

Results

From 1900 histologically confirmed EOC women, 347 patients were eligible for participations. The mean age of study patients was 51.31±11.37 years with the age range of 25 to 87 years. Uterine involvement was detected in 49.6% (173) of the patients either macroscopic (47.4%) or microscopic (52.6%) types. Uterine involvement was significantly associated with having AUB (P-value = 0.002), histological type of ovary tumor (P-value < 0.001), ovarian cancer stage (P-value < 0.001), and abnormal CA-125 concentration (P-value = 0.004). Compared to the other study patient, the patients with metastatic uterine involvement had significantly higher stage (p-value<0.001), higher grade of ovary tumor (p-value=0.008), serous histological type (p-value<0.001), and a higher level of CA-125 concentration (p-value<0.001). On the other hand, the patients with synchronous uterine cancer were significantly younger (p-value=0.013), nulliparous (p-value<0.001), suffered from AUB symptoms (p-value<0.001) and had endometroid histological type (p-value=0.010) of ovary cancer in comparison to other study patients.

Conclusion

Considering the high prevalence of uterine involvement in EOC patients, ultrasound evaluation and/or endometrium biopsy assessment should be done before planning any treatment

Disclosures

NOTHING TO DISCLOSURE

Serous carcinoma

Uterine cancer

10.1136/ijgc-2023-esgo.523

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Fuzzy Cellular Automata Based Random Numbers Generation

Trends in Applied Sciences Research (2011)

Ramin Ayanzadeh Azam Sadat Mousavi Ehsan Shahamatni

10.3923/tasr.2012.96.102

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Efficacy of combination therapy of oral zinc sulfate with imiquimod, podophyllin or cryotherapy in the treatment of vulvar warts

Journal of Obstetrics and Gynaecology Research (2014)

Setareh Akhavan Seyed Rahim Mohammadi Mitra Modarres Gillani Azam Sadat Mousavi Mahboobeh Shirazi

Abstract Aim Zinc sulfate is beneficial in the treatment of epithelial warts. We conducted this study to compare the efficacy of combination therapy of oral zinc sulfate with conventional treatments in the treatment of vulvar warts. Material and Methods This study was a randomized controlled trial. The sample size was 42 in each group. Women aged 20–50 years were placed by the block randomized method into six groups: the podophyllin‐, imiquimod‐ and cryotherapy‐treated groups, and another three groups receiving 8‐week combination therapy of 400 mg oral zinc sulfate with one of the above‐mentioned treatments. Data were analyzed using anova and F ischer's exact test with spss 16. Results A total of 228 patients were recruited and completed the study in six treatment groups. No significant difference was observed in the response to treatment among these groups. Relapse after 6 months was significantly higher in the podophyllin‐, imiquimod‐ and cryotherapy‐treated patients compared to patients receiving these treatments in combination with oral zinc sulfate ( P < 0.05). Conclusions Combined therapy of oral zinc sulfate with conventional treatments of vulvar warts appears to reduce the relapse rate.

Cryotherapy

Podophyllin

Imiquimod

Combination therapy

10.1111/jog.12457

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Citations (19)

Impact of diabetes mellitus on epithelial ovarian cancer survival

BMC Cancer (2018)

Setareh Akhavan Akram Ghahghaei‐Nezamabadi Mitra Modares-Gilani Azam Sadat Mousavi Mahdi Sepidarkish

Diabetes mellitus (DM) is associated with poorer outcomes in some cancers. Its effect on ovarian cancer is less clear. We consider the effect of DM on overall survival (OS) and progression free survival (PFS) in patients with epithelial ovarian cancer (EOC). A retrospective cohort study of 215 patients with EOC diagnosed between 2009 and 2016 was performed. Records were reviewed for standard demographic, pathologic and DM diagnosis data. Cox regression was used to evaluate the relationship between disease status and survival after adjustment for age, body mass index (BMI), parity, stage, grade, histology, debulking status, hypertension (HTN), menopause status and neoadjuant chemotherapy. Patients with DM (27.97, 95%CI: 23.63 to 32.30) had a significantly shorter OS rates compared to patients without DM (41.01, 95%CI: 38.84 to 43.17). The unadjusted hazard ratio (HR) for the association between OS time and DM was 4.76 (95%CI: 2.99 to 7.59, P < 0.001). Following adjustment for demographic and pathologic variables, the HR was 3.93 (95% CI: 2.01 to 7.68; P < 0.001). The PFS in patients with DM (14.10, 95%CI: 11.76 to 16.44) was significantly shorter compared to patients without DM (28.83, 95%CI: 26.13 to 31.54). The unadjusted HR for PFS and DM was 5.69 (95% CI: 3.05 to 10.61; P < 0.001). After adjustment for demographic and pathologic variables, the HR was 2.73 (95% CI, 1.18 to 6.95; P < 0.001). DM can negatively effect on PFS and OS in EOC patients independent of the effect of other variables.

Surgical oncology

10.1186/s12885-018-5162-3

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Citations (27)

Conservative management in young patients with borderline and malignant ovarian tumors: outcomes and pregnancies

International Journal of Reproductive BioMedicine (IJRM) (2008)

Fatemeh Ghaemmaghami Mojgan Karimi‐Zarchi Azita Naseri Azam Sadat Mousavi Mitra Modarres Gilani

Background: Recent studies have showed conservative management in selective patients with borderline and malignant ovarian tumors is safe; therefore this management is considered in patients with ovarian tumor who desire to preserve fertility. Objective: This study has been performed to evaluate the clinical outcome and fertility in patients with ovarian tumors who were treated conservatively. Materials and Methods: All patients who were treated conservatively (preservation of uterus and at least one ovary) or were on follow-up and had recurrence were evaluated in Vali-e-Asr Hospital during 2000-2004. Results: Among 410 patients with ovarian tumors, 60 were treated conservatively. Age range was 13-34 years. Twenty-six of patients (43.3%) were desired pregnancy and 34 (56%) patients did not. Three (5%) patients had history of infertility. Histological types of tumors were as follows; 15(25%) borderline tumors, 10(16.7%) epithelial tumors, 26(43.3%) germ cell tumors, and 9(15%) sex cord tumors. Range of follow-up time was 12-48 months. Seven term pregnancies in 6 patients had been occurred, 1 in epithelial group, 2 in germ cell group, 1 in sex cord group and 3 in borderline group. Nine patients had recurrence and 2 patients expired, including one patient with serous cyst carcinoma (Stage IIIC).This patient had refused radical surgery and referred to our center with recurrence. Another patient had immature teratoma (Stage IIIC). Conclusion: Conservative surgical management in young patients with stage I (grade 1, 2) of epithelial ovarian tumor and sex cord-stromal tumor and in patients with borderline and germ cell ovarian tumors could be performed in order to preserve fertility.

Ovarian tumor

Conservative Management

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Primary Malignant Melanoma of the Uterine Cervix

Journal of Lower Genital Tract Disease (2006)

Azam Sadat Mousavi Freshteh Fakor Zeinab Nazari Fatemeh Ghaemmaghami Farnaz Amouzegar Hashemi

Malignant melanoma of the uterine cervix is a rare neoplasm with poor prognosis. Diagnosis is confirmed by immunohistochemical methods and by exclusion of other primary sites of melanoma.In this paper, we are reporting a case of a 38-year-old patient with a malignant melanoma of the uterine cervix. Diagnosis was made by histological and immunohistochemical method. The tumor was stage IB1 of the International Federation of Gynecology and Obstetrics classification. Chest x-ray and abdominopelvic computed tomography scanning were normal. A radical hysterectomy with bilateral salpingo-oophorectomy and pelvic lymphadenectomy was performed. After performing combined radical surgery and irradiation, complete remission of the tumor was achieved. The patient has been followed for 24 months. She is well without any symptoms or signs of recurrence.Malignant melanoma is usually misdiagnosed specially in the chronic form. The immunohistochemical study is useful for definite diagnosis. Treatment is not well established, and the disease histogenesis has been controversial for a long time.

Primary (astronomy)

10.1097/01.lgt.0000229564.11741.4e

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Citations (37)

Investigating the Quality of Life of Patients with Cervical Cancer in Iran

Journal of Obstetrics Gynecology and Cancer Research (2022)

Mitra Modares Gilani Azam Sadat Mousavi Setareh Akhavan Shahrzad Sheikhhasani

Background & Objective: Cervical cancer is one of the most common cancers in women. One of the most important indicators that deal with all aspects of the patients' health is the Health-related quality of life (QOL). In this study, the QOL of women with cervical cancer in Iran was investigated.Materials & Methods: The present cross-sectional study examined the QOL of 139 patients with cervical cancer referred to Imam Khomeini hospital, affiliated with the Tehran University of Medical Sciences. For this study, a specific questionnaire of QOL in patients with cervical cancer was used. To determine the predictors of cervical cancer patients, the QOL linear regression model was used.Results: Findings of this study showed that the total score of QOL of patients was 20.97±1.29. Moreover, in the regression model, a significant relationship was observed between the type of treatment and patients' QOL scores and those patients who had neoadjuvant therapy plus surgery (β=-17.45, P < /i>=0.02) and those who received brachytherapy (β=- 14.86 and P < /i>=0.09) had a significantly lower QOL score.Conclusion: Overall, the QOL of people with cervical cancer was moderate. Implementing educational programs for service providers and choosing the appropriate type of treatment according to the stage of the disease and the patient's age can help control this type of disease and its complications and improve the QOL of patients.

Cross-sectional study

10.30699/jogcr.7.6.530

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Resistance to single‐agent chemotherapy and its risk factors in low‐risk gestational trophoblastic neoplasms

Journal of Obstetrics and Gynaecology Research (2014)

Azam Sadat Mousavi Ashraf Zamani Faezeh Khorasanizadeh Mitra Modarres Gilani Kazem Zendehdel

Abstract Aim Gestational trophoblastic neoplasm ( GTN ) is a rare disease which is classified into high‐ and low‐risk groups. While the high‐risk patients require combination therapy, the low‐risk groups respond to single‐agent chemotherapy. We studied resistance to single‐agent chemotherapy and its risk factors among the low‐risk GTN patients in I ran. Methods We followed 168 low‐risk GTN patients who were treated between 2001 and 2011 in V aliasr H ospital, T ehran, I ran. We used a case–control design and studied odds ratios ( OR ) and corresponding 95% confidence intervals ( CI ) to evaluate association between drug resistance and different personal and clinical variables. Results Resistance to sequential single‐agent chemotherapy was 19%, although all patients had a complete remission after a combination of chemotherapy and/or surgery. Patients who had I nternational F ederation of G ynecology and O bstetrics scores of 5–6 – considered as, the intermediate risk group – had a 14‐fold higher resistance compared with the low score patients ( OR = 14.28, 95% CI = 5.54–36.81). We found higher risk of resistance among patients with metastasis ( OR = 8.42, 95% CI = 2.44–29.07), large tumor size (>3 cm) ( OR = 7.73, 95% CI = 1.93–30.91), high β‐h CG (>100 000 IU /L) ( OR = 5.86, 95% CI = 1.07–32.02) and/or a diagnosis more than 4 months after pregnancy ( OR = 3.30, 95% CI = 1.08–10.02), compared with their reference group. We found no priority for the different chemotherapy regimens. Conclusion Intermediate risk GTN patients had a higher risk of resistance to chemotherapy compared with low‐risk patients. Clinical trials and cost‐effectiveness studies are needed to suggest a better treatment program for the intermediate risk group.

Trophoblastic neoplasm

Gestational Trophoblastic Disease

10.1111/jog.12613

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Impact of caffeine on heart rate and blood pressure at rest and during exercise

DOAJ (DOAJ: Directory of Open Access Journals) (2011)

Azam Sadat Mousavi Maryam Koushki Jahromi Mohsen Salesi Farhad Daryanoush Ebrahim Khoshnam

Rest (music)

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