Xiao Cheng

Shanxi Medical University

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Qin‐Shi Zhao

Kunming Institute of Botany

Li‐Yan Peng

Chinese Academy of Sciences

Juan He

Chinese Academy of Sciences

Xing‐De Wu

State Ethnic Affairs Commission

Xuan‐Qin Chen

Kunming University of Science and Technology

Kou Wang

Kunming Medical University

Mingming Li

Sichuan University

Gang Xu

Kunming Institute of Botany

Zheng‐Hong Pan

Chinese Academy of Sciences

Jia Su

Ningbo University

Cooperative Institutions

Chinese Academy of Sciences

University of Chinese Academy of Sciences

Kunming Institute of Botany

Chongqing University of Technology

Central South University

Chinese Academy of Medical Sciences & Peking Union Medical College

Zhejiang University

Chongqing University

Sichuan University

Sun Yat-sen University

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Triterpenoids and Diterpenoids from Viburnum chingii

Chemical and Pharmaceutical Bulletin (2011)

Xuan‐Qin Chen Yan Li Juan He Xiao Cheng Kou Wang

Two new oleanane triterpenoids (1—2) and one new vibsane-type diterpenoid (3), together with 7 known compounds (4—10), were isolated from the leaves of Viburnum chingii. The structures of compounds 1—3 were elucidated by means of spectroscopic methods including extensive 1D- and 2D-NMR technique. Cytotoxicity of compounds 1—10 were tested against HL-60, SMMC-7721, A-549, SK-BR-3, and PANC-1 cell lines. Compound 3 showed significant cytotoxicity against HL-60, SK-BR-3, and PANC-1 cell lines.

Viburnum

Oleanane

Caprifoliaceae

Terpene

10.1248/cpb.59.496

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Citations (16)

Euglobal-IIIa, a novel acylphloroglucinol-sesquiterpene derivative from Eucalyptus robusta: absolute structure and cytotoxicity

Natural Products and Bioprospecting (2011)

Li‐Yan Peng Juan He Gang Xu Xing‐De Wu Liao‐Bin Dong

Euglobal-IIIa (1), a novel acylphloroglucinol-sesquiterpene derivative, and a known analogue, have been isolated from leaves of Eucalyptus robusta. The structures was elucidated by extensive spectroscopic data and by comparison with data reported in literature, while the absolute configuration of 1 was determined by the X-ray diffraction analysis. Compound 1 exhibited comparable cytotoxicity with that of cisplatin against five human cancer cell lines HL-60, SMMC-7721, A-549, MCF-7, and SW480 with IC50 values of 15.7, 15.5, 17.6, 14.3, and 21.8 µM, respectively.

Absolute Configuration

Derivative (finance)

Plant biochemistry

Cancer cell lines

Bioorganic chemistry

10.1007/s13659-011-0021-9

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Citations (12)

Lycojapodine A, a Novel Alkaloid from Lycopodium japonicum

Organic Letters (2009)

Juan He Xuan‐Qin Chen Mingming Li Yu Zhao Gang Xu

Lycojapodine A, a novel C16N-type Lycopodium alkaloid with an unprecedented 6/6/6/7 tetracyclic ring system, was isolated from the club moss Lycopodium japonicum. The structure and relative stereochemistry were elucidated on the basis of spectroscopic data and were further confirmed by X-ray analysis. A possible biosynthetic pathway for 1 was proposed. Its inhibitory activity on acetylcholinestrease and anti-HIV-1 activity were also evaluated.

Lycopodium

10.1021/ol900079t

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Citations (67)

ChemInform Abstract: Evollionines A—C, Three New Alkaloids Isolated from the Fruits of Evodia rutaecarpa.

ChemInform (2015)

Yanhong Li Juan He Yan Li Xing‐De Wu Li‐Yan Peng

Abstract Three new alkaloids, evollionines A (I), B (II), and C (III), are isolated together with two known compounds, evodianinine and wuzhuyumide I.

10.1002/chin.201519265

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Terpenoids from Two Dicranopteris Species

Helvetica Chimica Acta (2008)

Xiaoli Li Lin Tu Yu Zhao Li‐Yan Peng Gang Xu

Abstract Two new compounds, (6 S ,13 S )‐6‐{[ β ‐ D ‐glucopyranosyl‐(1→4)‐ α ‐ L ‐rhamnopyranosyl]oxy}cleroda‐3,14‐dien‐13‐ol ( 1 ) and kadsuric acid 3‐methyl ester ( 2 ), together with nine known compounds, (6 S ,13 E )‐6‐{[ β ‐ D ‐glucopyranosyl‐(1→4)‐ α ‐ L ‐rhamnopyranosyl]oxy}cleroda‐3,13‐dien‐15‐ol ( 3 ), (6 S ,13 S )‐6‐[6‐ O ‐acetyl‐ β ‐ D ‐glucopyranosyl‐(1→4)‐ α ‐ L ‐rhamnopyranosyl]oxy}‐13‐{[ α ‐ L ‐rhamnopyranosyl‐(1→4)‐ β ‐ D ‐fucopyranosyl]oxy}cleroda‐3,14‐diene ( 4 ), (6 S ,13 S )‐6‐{[6‐ O ‐ β ‐ D ‐glucopyranosyl‐(1→4)‐ α ‐ L ‐rhamnopyranosyl]oxy}‐13‐{[ α ‐ L ‐rhamnopyranosyl‐(1→4)‐ β ‐ D ‐fucopyranosyl]oxy}cleroda‐3,14‐diene ( 5 ), 15‐hydroxydehydroabietic acid ( 6 ), 15‐hydroxylabd‐8(17)‐en‐19‐oic acid ( 7 ), junicedric acid ( 8 ), (4 β )‐kaur‐16‐en‐18‐oic acid ( 9 ), (4 β )‐16‐hydroxykauran‐18‐oic acid ( 10 ), and (4 β ,16 β )‐16‐hydroxykauran‐18‐oic acid ( 11 ) were isolated from the fronds of Dicranopteris linearis or D. ampla. Their structures were established by extensive 1D‐ and 2D‐NMR spectroscopy. Compounds 1 and 3 – 8 showed no anti‐HIV activities.

Frond

10.1002/hlca.200890089

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Citations (14)

Further Lignans from Saururus chinensis

Planta Medica (2013)

Xiu Gao Juan He Xing‐De Wu Li‐Yan Peng Liao‐Bin Dong

Three new sauchinone analogues, sauchinones B-D (1-3), together with sauchinone (4), were isolated from the aerial part of Saururus chinensis. Structures of the new compounds were determined by extensive spectroscopic data as well as X-ray analysis. Compounds 3 and 4 inhibited nitric oxide production in lipopolysaccharide stimulated RAW 264.7 cells with IC50 values of 13.0 and 14.2 µM, respectively.

10.1055/s-0033-1351053

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Citations (15)

The In Vitro Reconstitution of Nucleosome and its Binding Patterns with HMG1/2 and HMG14/17 Proteins

Cell Research (2003)

Shu Bing ZHANG Jian Huang Hui Zhao Yi Zhang Chun Hou

Naked DNA

10.1038/sj.cr.7290180

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Citations (4)

Four new labdane-type diterpenoid glycosides from Diplopterygium laevissimum

Natural Products and Bioprospecting (2013)

Mingming Li Kou Wang Juan He Li‐Yan Peng Xuan‐Qin Chen

Four new labdane-type diterpenoid glycosides, laevissiosides A-D (1–4) were isolated from the 95% ethanol extract of Diplopterygium laevissimum (Christ) Nakai, along with two known analogues, 18- β-D-glucopyranosyl ester-sclareol (5) and 18-hydroxy-sclareol (6). The structures of compounds 1–4 were elucidated by extensive 1D and 2D NMR spectroscopy as well as high-resolution MS analyses. All isolated compounds were evaluated for their cytotoxic effects.

Labdane

Plant biochemistry

10.1007/s13659-012-0022-3

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Citations (9)

Phenolic Constituents from Brainea insignis

Chemical and Pharmaceutical Bulletin (2010)

Kou Wang Mingming Li Xuan‐Qin Chen Li‐Yan Peng Xiao Cheng

Phytochemical investigation on the methanol extract of Brainea insignis led to the isolation of 16 phenolic compounds, including an unusual flavanol coupled with phenylpropyl and shikimic acid units, brainicin (1), and a new flavonol acylglycosides brainoside B (2). The structures of new compounds were elucidated on the basis of extensive spectroscopic analysis. Compounds 1—5 were evaluated for their cytotoxic effects. However, none of the compounds showed significant cytotoxic activity against the HL-60, A549, SMMC-7721, MCF-7, SW480 cell lines (IC50>40 μM).

Phytochemical

Shikimic acid

10.1248/cpb.58.868

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Citations (13)

ChemInform Abstract: Four New Lignans from Viburnum foetidum var. foedidum.

ChemInform (2010)

Xuan‐Qin Chen Yan Li Juan He Kou Wang Mingming Li

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Viburnum

10.1002/chin.201011203

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Citations (0)