Novelli Gp

University of Florence

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C Cortesini

University of Florence

E Pagni

Azienda Ospedaliero-Universitaria Careggi

S Falchi

Academic Rights Press (United Kingdom)

R. Francini

University of Rome Tor Vergata

E Paternostro

University of Florence

Robert E. Casali

University of Florence

Chiara Adembri

University of Florence

M Ariano

Naples Anesthesia & Physician Associates

Ryouji Tani

Hiroshima University

C Pallini

Novo Nordisk (Denmark)

Cooperative Institutions

University of Florence

Azienda Ospedaliero-Universitaria Careggi

Istituti di Ricovero e Cura a Carattere Scientifico

University of Pisa

Sapienza University of Rome

Vita-Salute San Raffaele University

Università Cattolica del Sacro Cuore

San Raffaele University of Rome

University of Turin

University of Bologna

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[Evaluation of the synergism between ketorolac and morphine in the treatment of postoperative pain].

PubMed (1995)

Robert E. Casali G Girardi Mediati Rd P Livi Novelli Gp

The aim of the study is to determine what concentration of ketorolac and morphine administered together i.v. achieve best synergic effect between NSAID antiinflammatory and opioids analgesic properties.Randomized comparative study was carried out on 180 patients, ASA II-IV, undergoing major general surgery, in an University Clinic.Postoperative pain therapy by i.v. PCA: group 1 morphine 0.75 mg.ml + ketorolac 0.75 mg.ml; group 2 morphine 0.50 mg.ml + ketorolac 1.50 mg.ml; group 3 morphine 0.25 mg.ml + ketorolac 1.50 mg.ml; in saline solution. Initial bolus: 2 ml. Continuous infusion 1.5 ml.h. Demand bolus: 0.2 ml. Lockout time: 30 minutes. Evaluations included: pain intensity (T0, T3, T18); total amount of infused drugs (T18); number of valid demands and attempts (T18); amount of autoadministered analgesic drugs in percent of highest available amount (T18); side effects (T18); patient's judgment.ANOVA and Student's "t"-test.A statistically significant reduction of pain intensity was found after 3 and 18 hours in the three groups, no differences were found among the groups. Group 2 required an amount of autoadministered drugs significantly lower than other groups. Rare side effects. Patient's judgment was generally positive.Results suggest a greater synergetic effect between morphine and ketorolac in concentrations used in group 2.

Bolus (digestion)

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Citations (2)

Antioxidant drugs in cerebral and spinal ischemia.

PubMed (1994)

Novelli Gp Melani Am Guglielmo Consales E Paternostro

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Citations (2)

[Anesthesia for catheterization of the cardiac cavity].

PubMed (1961)