Hyo-Jeong Ban

Centers for Disease Control and Prevention

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Bok-Ghee Han

Korea National Institute of Health

Bok‐Ghee Han

Korea Center for Disease Control and Prevention

Mark I. McCarthy

University of Oxford

Chol Shin

Ansan University

Taesung Park

Seoul National University

Dan-Kyu Yoon

Korea National Institute of Health

Haesook Min

Korea National Institute of Health

Lon R. Cardon

Jackson Laboratory

Mi Hee Lee

Yonsei University

Ji Hee Oh

Eulji University

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Korea National Institute of Health

Yonsei University

Seoul National University

Korea Center for Disease Control and Prevention

Centers for Disease Control and Prevention

Korea Disease Control and Prevention Agency

Seoul National University Hospital

Sungkyunkwan University

Korea University

Hallym University

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Human transcriptome analysis of acute responses to glucose ingestion reveals the role of leukocytes in hyperglycemia-induced inflammation

Physiological Genomics (2012)

Hyung Jin Choi Hye Sun Yun Hyun Ju Kang Hyo-Jeong Ban Yeonjung Kim

Glucose ingestion-induced hyperglycemia has been known to induce inflammation, which is related to the pathogenesis of diabetic complications. To examine acute gene expression responses to physiological oral glucose ingestion in human circulating leukocytes, we conducted a microarray study of human circulating leukocytes sampled before, 1 h after, and 2 h after glucose ingestion in community-based participants without previous histories of diabetes (n = 60). Ingestion of 75 g glucose successfully induced acute hyperglycemia (glucose concentration 91.6 ± 5.3 mg/dl for fasting and 180.7 ± 48.5 mg/dl for 1 h after glucose ingestion). Oral glucose ingestion significantly increased the expressions of 23 genes and decreased the expressions of 13 genes [false discovery rate (FDR) P value <0.05]. These genes are significantly involved in immunity by way of natural killer cell-mediated immunity, granulocyte-mediated immunity, and the cytokine-mediated signaling pathway (FDR P value <0.05). The present study demonstrated 36 genes that showed acute gene expression change in human leukocytes within 1 h after glucose ingestion, suggesting that leukocytes participate in the inflammatory process induced by acute hyperglycemia. We believe that these results will provide some basic insight into the role of leukocytes in hyperglycemia-induced inflammation and the pathogenesis of diabetic complications.

Pathogenesis

10.1152/physiolgenomics.00179.2011

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Replication of genome-wide association studies on asthma and allergic diseases in Korean adult population

BMB Reports (2012)

Dan-Kyu Yoon Hyo-Jeong Ban Young Jin Kim Eun‐jin Kim Hyung-Cheol Kim

Allergic diseases such as asthma, allergic rhinitis, and atopic dermatitis are heterogeneous diseases characterized by multiple symptoms and phenotypes. Recent advancements in genetic study enabled us to identify disease associated genetic factors. Numerous genome-wide association studies (GWAS) have revealed multiple associated loci for allergic diseases. However, the majority of previous studies have been conducted in populations of European ancestry. Moreover, the associations of single nucleotide polymorphisms (SNPs) with allergic diseases have not been studied amongst the large-scale general Korean population. Herein, we performed the replication study to validate the previous variants, known to be associated with allergic diseases, in the Korean population. In this study, we categorized three allergic related phenotypes, one allergy and two asthma related phenotypes, based on self-reports of physician diagnosis and their symptoms from 8,842 samples. As a result, we found nominally significant associations of 6 SNPs with at least one allergic related phenotype in the Korean population.

Genome-wide Association Study

Genetic Association

10.5483/bmbrep.2012.45.5.305

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A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits

Nature Genetics (2009)

Yoon Shin Cho Min Jin Go Young Jin Kim Jee Yeon Heo Ji Hee Oh

Genome-wide Association Study

Genetic Association

10.1038/ng.357

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Citations (998)