Charles Allerson

Regulus Therapeutics (United States)

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Adam Pavlı́ček

AnaBios (United States)

Christiane Metz-Weidmann

Sanofi (Germany)

Sabine Scheidler

Sanofi (Germany)

Sonya Zabludoff

Nitto (United States)

Jack Pollard

Sanofi (United States)

Chaomei Shi

Sanofi (France)

Jennifer L. Rocnik

Constellation Pharmaceuticals (United States)

Shih-Min A. Huang

Cathay General Hospital

Raffaele Baffa

Regend Therapeutics (China)

Timothy R. Wagenaar

Sanofi (United States)

Cooperative Institutions

Grace (United States)

194

ShinEtsu Chemical (Japan)

166

Ionis Pharmaceuticals (United States)

Harvard University

Regulus Therapeutics (United States)

Weatherford College

National Institutes of Health

Sanofi (United States)

Vanderbilt University

AVEO Oncology (United States)

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Supplementary Figure 2 from Anti–miR-21 Suppresses Hepatocellular Carcinoma Growth via Broad Transcriptional Network Deregulation

Timothy R. Wagenaar Sonya Zabludoff Sung‐Min Ahn Charles Allerson Heike Arlt

Supplementary Figure 2. Anti-miR-21 treatment causes limited caspase 3/7 activation in non-transformed cell lines. Caspase 3/7 activation after treatment of SKHep1, IMR-90, and WI-38 cells with MM control or anti-miR-21 for 72 hours. (Mean, {plus minus} SEM, n=3).

Deregulation

10.1158/1541-7786.22513677

Cite

Citations (0)

CCDC 875362: Experimental Crystal Structure Determination

The Cambridge Structural Database (2012)

Punit P. Seth Charles Allerson Mads Østergaard E.E. Swayze

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/ccycwhn

Cite

Citations (0)

Supplementary Figure 1 from Anti–miR-21 Suppresses Hepatocellular Carcinoma Growth via Broad Transcriptional Network Deregulation

Timothy R. Wagenaar Sonya Zabludoff Sung‐Min Ahn Charles Allerson Heike Arlt

Supplementary Figure 1. miR-21 mimic suppresses expression of ANKRD46, DDAH1 and RECK. SKHep1 cells were transfected with miR-21 or negative mimic. RNA was isolated and expression of ANKRD46, DDAH1 and RECK was assessed by qPCR. (Mean, {plus minus} SD, n=3).

Deregulation

10.1158/1541-7786.22513680

Cite

Citations (0)

Supplementary Figure 4 from Anti–miR-21 Suppresses Hepatocellular Carcinoma Growth via Broad Transcriptional Network Deregulation

Timothy R. Wagenaar Sonya Zabludoff Sung‐Min Ahn Charles Allerson Heike Arlt

Supplementary Figure 4. Pathway analysis of gene expression changes following anti-miR-21 treatment. SKHep1 cells treated with anti-miR-21 were subjected to microarray gene expression analysis. Changes in cellular processes (top) and pathways (bottom) upon anti-miR-21 treatment are shown.

Deregulation

10.1158/1541-7786.22513671

Cite

Citations (0)

Author Index

Journal of Biological Chemistry (1999)

Edward Alexander Charles Allerson Raquel Almeida Anni H. Andersen Norma Andrews

10.1016/s0021-9258(19)55164-x

Cite

Citations (0)

Cumulative Author Index

Journal of Biological Chemistry (1999)

Robert Aarhus Stuart A. Aaronson Michelle Aarts Yama Abassi Angelo Abbondandolo

10.1016/s0021-9258(19)76954-3

Cite

Citations (0)

Supplementary Table 1 and Table 2 from Anti–miR-21 Suppresses Hepatocellular Carcinoma Growth via Broad Transcriptional Network Deregulation

Timothy R. Wagenaar Sonya Zabludoff Sung‐Min Ahn Charles Allerson Heike Arlt

Supplementary Tables 1 and 2. Supplementary Table 1: Fold de-repression of miR-21 target genes after anti-miR-21 treatment. Supplementary Table 2: Taqman Primer and Probes

Table (database)

TaqMan

Primer (cosmetics)

10.1158/1541-7786.22513665

Cite

Citations (0)

Replacing the 2′-oxygen with an exocyclic methylene group reverses the stabilization effects of α-l-LNA

Bioorganic & Medicinal Chemistry Letters (2010)

Punit P. Seth Charles Allerson Andrés Berdeja Eric E. Swayze

Methylene

Duplex (building)

Nucleobase

10.1016/j.bmcl.2010.10.025

Cite

Citations (11)

Regioselective Syntheses of 7-Nitro-7-deazapurine Nucleosides and Nucleotides for Efficient PCR Incorporation

Organic Letters (2005)

Tomohiko Kawate Charles Allerson Jia Liu Wolfe

Substitution at the C7 position of purine nucleotides by a potent electron-withdrawing nitro group facilitates the cleavage of glycosidic bonds under alkaline conditions. This property is useful for sequence-specific cleavage of DNA containing these analogues. Here we describe the preparation of 7-deaza-7-NO2-dA and 7-deaza-7-NO2-dG using two different approaches, starting from 2'-deoxy-adenosine and 6-chloro-7-deaza-guanine, respectively. These modified nucleosides were converted to nucleotide triphosphates, each of which can replace the corresponding, naturally occurring triphosphate to support PCR amplification.

10.1021/ol051144r

Cite

Citations (15)

Insights from Crystal Structures into the Opposite Effects on RNA Affinity Caused by the S- and R-6′-Methyl Backbone Modifications of 3′-Fluoro Hexitol Nucleic Acid

Biochemistry (2011)

Pradeep S. Pallan Jinghua Yu Charles Allerson Eric E. Swayze Punit P. Seth

Locked nucleic acid (LNA) analogues with 2′,4′-bridged sugars show promise in antisense applications. S-5′-Me-LNA has high RNA affinity, and modified oligonucleotides show weakened immune stimulation in vivo. Conversely, an R-5′-methyl group dramatically lowers RNA affinity. To test the effects of S- and R-6′-methyl groups on 3′-fluoro hexitol nucleic acid (FHNA) stability, we synthesized S- and R-6′-Me-FHNA thymidine and incorporated them into oligo-2′-deoxynucleotides. As with LNA, S-6′-Me is stabilizing whereas R-6′-Me is destabilizing. Crystal structures of 6′-Me-FHNA-modified DNAs explain the divergent consequences for stability and suggest convergent origins of these effects by S- and R-6′-Me (FHNA) [-5′-Me (LNA and RNA)] substituents.

Nucleic acid structure

10.1021/bi201810r

Cite

Citations (15)