Mohammad Mahdi Sagheb

Shiraz University of Medical Sciences

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Jamshid Roozbeh

Shiraz University of Medical Sciences

Iman Karimzadeh

Shiraz University of Medical Sciences

Maryam Moini

University of Ottawa

Maryam Sharifian

Shahid Beheshti University

Zahra Sohrabi

Shiraz University of Medical Sciences

Banafshe Dormanesh

Aja University of Medical Sciences

Raha Afshariani

Shiraz University of Medical Sciences

Mohammad Kazem Fallahzadeh

Emory University

Bita Geramizadeh

Shiraz University of Medical Sciences

Saeed Behzadi

Shiraz University of Medical Sciences

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Shiraz University of Medical Sciences

214

American Society of Nephrology

Shiraz University

Fresenius Medical Care North America (United States)

Fresenius Medical Care (United States)

University of California, Santa Barbara

Universidad Rovira i Virgili

University of Cologne

Tehran University of Medical Sciences

Başkent University

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Effect of Whey Beverage Fortified with Vitamin E on Quality of Life in Hemodialysis Patients

DOAJ (DOAJ: Directory of Open Access Journals) (2017)

Zahra Sohrabi Mohammad Eftekhari Marzieh Akbarzadeh Mohammad Hadi Eskandari Mohammad Mahdi Sagheb

Background: Whey protein can improve quality of life and vitamin E can reduce oxidative stress. Due to the reduced quality of life in hemodialysis patients, this study was conducted to evaluate the effect of whey beverage fortified with vitamin E on quality of lifein hemodialysis patients. Methods: Ninety two 17 to 65 years old patients who were on hemodialysis were randomly assigned to four groups of (i) 1 receiving whey beverage fortified with vitamin E, (ii) 2 receiving whey beverage, (iii) 3 receiving vitamin E, and (iv) 4 as the control group receiving no intervention. SF-12 questionnaire was used for assessing quality of life in the participants. Results:Bodily pain score improved significantly in group 3 while, a significant decline was seen for bodily pain in control group. An improvement was seen in groups 1 and 2. Physical health showed a significant improvement in group 1. Considering social functioning scores, improvement in whey beverage and vitamin E groups was seen. An improvement of quality of life in whey beverage fortified with vitamin E was noticed. Conclusion: Whey protein and vitamin E were shown to reduce oxidative stress and their effect on neurotransmitters in brain such as serotonin and dopamine leads to improvement in quality of life in hemodialysis patients. Doing longer studies with questionnaires such as SF-36, may help precise investigation of whey protein and vitamin E effects on quality of life of hemodialysis patients.

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Impact of oral zinc therapy on the level of sex hormones in male patients on hemodialysis

Renal Failure (2010)

G R Jalali Jamshid Roozbeh Azam Mohammadzadeh Maryam Sharifian Mohammad Mahdi Sagheb

Background: Sexual dysfunction in chronic renal failure patients undergoing hemodialysis is common. It is demonstrated that the zinc level is significantly lower in the hemodialysis patients. Objective: In this clinical trial, we investigate the effect of zinc supplement therapy on the serum levels of sexual hormones in hemodialysis male patients. Patients and methods: We carried out a clinical trial study including 100 of our male patients with end-stage renal disease on hemodialysis. Testosterone, follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin, and zinc plasma level were measured in all of the patients. The patients received zinc supplement (zinc sulfate, 250 mg/day) for 6 weeks, and sex hormones and zinc plasma level were checked again. Results: Serum level of FSH and prolactin did not have any significant changes before and after intervention, but serum level of testosterone, LH, and zinc increased significantly. Discussion: These results suggest that although zinc administration did not have a definite effect on hemodialysis patients with sexual dysfunction, it can cause increase in the serum level of sex hormones which may improve the sexual function of the patients in some aspects.

10.3109/08860221003706958

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Dietary intake of phosphorous and protein in Shiraz, Iran: A comparison of three assessment methods

Journal of Food Composition and Analysis (2017)

Samane Rahmdel Batool Farahbod Seyed Mohammad Mazloomi Mohammad Mahdi Sagheb Siavash Babajafari

Food composition data

10.1016/j.jfca.2017.05.012

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Pars cohort study of non-communicable diseases in Iran: protocol and preliminary results

International Journal of Public Health (2016)

Abdullah Gandomkar Hossein Poustchi Maryam Moini Mohsen Moghadami Hadi Imanieh

Non-communicable disease

10.1007/s00038-016-0848-2

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The booster phenomenon of tuberculin skin testing in patients receiving hemodialysis.

PubMed (2008)

Mohammad Mahdi Sagheb Mandana Goodarzi Jamshid Roozbeh

The risk of developing tuberculosis is high among chronic hemodialysis patients. The tuberculin skin test (TST) has been in use for diagnosing latent TB, but few data are available on TST in hemodialysis patients.This study was done to identify the TST reactivity and frequency of booster effect in serial TST among hemodialysis patients.A total of 100 patients in three hemodialysis centers were prospectively tested. Patients with less than 10mm indurations were given additional TST one and four weeks later to determine the frequency of booster effect.The cumulative prevalence of a positive TST was 7 % for the first test and 16 % for the third test. There was a weak, but significant correlation between TST positivity, serum albumin level, urea reduction ratio and KT/V (p<0.05). There was no influence of age, gender, hemodialysis duration and primary renal disease.This study showed that the TST reactivity and booster effect among our hemodialysis patients in Iran are lower than in other societies. Inadequate hemodialysis and poor nutrition may contribute to the lower tuberculin skin test reactivity in our hemodialysis patients.

Booster (rocketry)

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Teaching Evidence-Based Medicine (EBM) to Undergraduate Medical Students through Flipped Classroom Approach

Shiraz E-Medical Journal (2017)

Mohammad Mahdi Sagheb Mitra Amini Mahboobeh Saber Mohsen Moghadami Parisa Nabiei

Introduction: Medical students should be trained about the fundamental skills of evidence- based medicine (EBM) during undergraduate medical education curriculum. This article introduces an innovative model for initiation and development of a flipped classroom for teaching EBM to sixth- year undergraduate medical students in Shiraz Medical School, affiliated to Shiraz University of Medical Sciences. Methods: After conducting needs assessment and setting objectives for the program, blended leaning format and flipped classroom strategy were used. A student satisfaction measurement form was designed to evaluate the flipped classroom based on a 5-point Likert scale. The validity of the questionnaire was determined by experts, and the reliability of the questionnaire was 0.86 after a pilot study. We also used the questionnaires based on Berlin questionnaire to measure students' knowledge, attitude, and practice about the EBM course in a pre- and posttest design. The validity and reliability of the questionnaire had been approved in our previous study. Also, the result of a summative examination after finishing the course was used as a measure of course goal achievement. Results: A total of 280 medical students on their sixth year of study participated in the flipped classroom in 6 different rotations. A total of 266 (95%) students passed the course and only 14 (%5) failed. The results of posttest scores based on the EBM domains revealed that the best result was obtained in teaching clinical questions' format (patient, intervention, comparison, and outcome). The lowest posttest scores were in the domain of biostatistics. The overall quality of flipped classroom was reported well by the students. The students stated that the ability to apply knowledge and skills in managing patients were developed in this course. Discussions: In our experience, flipping classroom was a practical and essential activity to educate a large number of medical students about EBM. We acknowledge that the development of deep learning is instructors' responsibility and that implementing blended learning and flipping classroom can facilitate students' knowledge and skills about this important topic. We hope that other medical schools all over the world use the flipped classroom discussed in this article to redesign their classrooms in such a way that enables students to develop necessary skills and get involved in deep learning. This will improve the health of the society in the near future.

Flipped Classroom

10.5812/semj.57150

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Association of Zinc Deficiency and Depression in the Patients With End-stage Renal Disease on Hemodialysis

Journal of Renal Nutrition (2010)

Jamshid Roozbeh Maryam Sharifian Ahmad Ghanizadeh Ali Sahraian Mohammad Mahdi Sagheb

Depression

10.1053/j.jrn.2010.05.015

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Acute renal failure in the first 100 orthotopic liver transplant patients in Southern Iran.

Ghanbar-Ali Rais-Jalali Mohammad Mahdi Sagheb Farzad Daniali Saeed Behzadi Jamshid Roozbeh

Postoperative acute renal failure is a frequent and serious medical complication following orthotopic liver transplant. Here, we report our experiences with liver transplant recipients who developed acute renal failure in the early period following orthotopic liver transplant. Among 100 liver transplants performed between April 1993 and January 2004, we retrospectively analyzed 91 patients (mean age, 29.9 +/- 14.0 years) who had undergone orthotopic liver transplant. The underlying causes of liver failure were cryptogenic liver cirrhosis (n=27), viral hepatitis (n= 21) (hepatitis-B-related liver cirrhosis [n=13], hepatitis-C-related liver cirrhosis [n=7], and hepatitis-B- and C-related liver cirrhosis [n=1]), autoimmune hepatitis (n=18), Wilson's disease (n=10), primary sclerosing cholangitis (n=8), biliary atresia (n=3), Budd-Chiari syndrome (n=2), and primary biliary cirrhosis (n=2). The immunosuppressive regimen included mycophenolate mofetil (azathioprine for 10 patients), cyclosporine, and steroids. Six patients received a combination of tacrolimus and steroids. Ten patients (10.9%) experienced acute renal failure, 7 (70%) were men, and none of them required renal replacement therapy and/or died. Four patients were diagnosed as having cryptogenic liver cirrhosis; 2 with hepatitis-C-related liver cirrhosis, 2 with autoimmune liver cirrhosis; 1 with primary biliary cirrhosis; and 1 hepatitis-B-related liver cirrhosis. Six patients were Child-Pugh's classification C, and the others were B. The rate of postoperative acute renal failure in our patients was relatively low when compared with other series, and our outcomes were good.

Autoimmune Hepatitis

Primary Sclerosing Cholangitis

Liver disease

Primary Biliary Cirrhosis

Hepatitis C

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Acute interstitial nephritis in the south of Iran; an observational study

Journal of Nephropathology (2017)

Zohre Khodamoradi Maryam Pakfetrat S Torabinezhad Mohammad Mahdi Sagheb

Acute interstitial nephritis (AIN) is an emerging cause of acute kidney injury (AKI) during the recent years.There is no data about prevalence, causes, clinical manifestation and outcomes of AIN in our region. Hence, in this study we aimed to find the prevalence of AIN and describe the causes, clinical presentation, and the outcome of AIN in the native kidney biopsies.We reviewed 934 native kidney biopsies from 2006 to 2014 and collected the data of patients with the diagnosis of AIN including medical history, clinical findings, para-clinical data, pathologic findings, treatment and outcomes.Prevalence of AIN in our center during 2006 to 2014 was 2.5% of all renal biopsies. The common cause of AIN in our study was drugs. Of those patients admitted to hospital due to AIN, 17 patients (70.8%) received corticosteroid, five of them (29.4%) received pulse of corticosteroid, and 12 patients (70.6%) received oral drug. Around, 54.2% of the patients had hemodialysis during admission. Eight patients had received both dialysis and corticosteroid. Two of them (8.3%) remained on dialysis and 8 (33.3%) developed chronic kidney disease, but 14 (58.3%) patients recovered.The prevalence of AIN in our study is comparable to other studies and we found the great impact of medications on development of AIN.

Interstitial nephritis

Nephritis

10.15171/jnp.2017.37

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Prevalence, Awareness, Treatment, Control, and Correlates of Hypertension in the Pars Cohort Study.

PubMed (2018)

Abdullah Gandomkar Hossein Poustchi Fatemeh Malekzadeh Masoud Malekzadeh Maryam Moini

High blood pressure is an important risk factor for all-cause mortality and cardiovascular mortality and morbidity among Iranians. We aimed to estimate its prevalence, correlates, and its rate of awareness, treatment, and control in South of Iran.The Pars Cohort Study (PCS) was launched in a district of Fars province. All residents between 40 and 75 years old in the district were recruited from 2012 to 2014. Hypertension was defined as either systolic/diastolic blood pressure ≥ 140/90 mm Hg or taking medications. Logistic regression was used to identify the correlates of hypertension and awareness and its treatment and control. A total of 9264 participants were recruited. Of the total participants, 46.2% were men. The mean age was 52.6 years (SD: 9.7).Prevalence of hypertension was 26.9%. Of the total 2489 hypertensives, 49.6% were aware and 55.7% were under treatment. Blood pressure was controlled in 69.2% of treated hypertensives. In the adjusted model, female sex and history of cardiovascular disease (CVD) were positively associated with having hypertension, higher awareness, and better treatment and control. Older age, being overweight or obese, and having a history of diabetes were also positively associated with having hypertension and higher awareness and treatment; however, being overweight or obese was associated with poorer hypertension control. Older age and having a history of diabetes did not show a statistically significant association with control.Being underweight and higher physical activity were inversely associated with having hypertension but were not associated with awareness, treatment, or control. Prevalence of hypertension is high but the rates of awareness, treatment, and control are not adequate.

Underweight

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