Tadahiko Ito

Hiraka General Hospital

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Goro Takada

Ashikaga Red Cross Hospital

Masamichi Tamura

Tokyo Institute of Technology

Kenji Harada

Jichi Medical University

Yasushi Takahashi

Sendai Medical Center

Yukinori Okazaki

Toyonaka Municipal Hospital

Tadayoshi Takemoto

Yamaguchi University

Tsuyoshi Aibe

Japan Organization of Occupational Health and Safety

Akira Ishida

Kobe University

Kazuo Momma

Tohoku University

Tomoharu Yoshida

Tokyo University of Science

Cooperative Institutions

Yamaguchi University

Akita University

Tohoku University

Japan Organization of Occupational Health and Safety

The University of Tokyo

Tokyo Metropolitan Institute of Public Health

Yamaguchi University Hospital

Akita University Hospital

Nakadōri General Hospital

Osaka University

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New Ehrlichia Species Closely Related to Ehrlichia chaffeensis Isolated from Ixodes ovatus Ticks in Japan

Journal of Clinical Microbiology (2000)

Shin-ichiro Shibata Makoto Kawahara Yasuko Rikihisa Hiromi Fujita Yuriko Watanabe

ABSTRACT Seven Ehrlichia strains (six HF strains and one Anan strain) that were obtained from laboratory mice by intraperitoneally inoculating homogenates of adult Ixodes ovatus collected in Japan were characterized. 16S rRNA sequences of all six HF strains were identical, and the sequences were 99.7, 98.2, and 97.7% identical to those of Anan strain, Ehrlichia chaffeensis (human monocytic ehrlichiosis agent), and E. muris , respectively. Partial GroEL amino acid sequencing also revealed that the six HF strains had identical sequences, which were 99.0, 98.5, and 97.3% identical to those of E. chaffeensis , the Anan strain, and E. canis , respectively. All HF strains were lethal to mice at higher dosages and intraperitoneal inoculation, whereas the Anan or E. muris strain induced only mild clinical signs. Light and electron microscopy of moribund mice inoculated with one of the HF strains revealed severe liver necrosis and the presence of numerous ehrlichial inclusions (morulae) in various organs. The study revealed that members of E. canis genogroup are naturally present in Ixodes ticks. HF strains that can cause severe illness in immunocompetent laboratory mice would be valuable in studying the pathogenesis and the roles of both cellular and humoral immune responses in ehrlichiosis caused by E. canis genogroup.

Ehrlichia chaffeensis

Ehrlichia canis

Ehrlichiosis

Strain (injury)

10.1128/jcm.38.4.1331-1338.2000

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Citations (134)

DIAGNOSIS OF LYMPH NODE METASTASIS OF ESOPHAGEAL CANCER BY ENDOSCOPIC ULTRASONOGRAPHY (2ND REPORT)

Acta gastro-enterologica belgica (1987)

Tadahiko Ito Tsuyoshi Aibe Tomoharu Yoshida Takayoshi Noguchi Kazutaka Nakata

Endoscopic ultrasonography

10.11280/gee1973b.29.1117

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Citations (0)

In Situ Morphology of the Foramen Ovale in the Fetal and Neonatal Rat

Pediatric Research (1992)

Kazuo Momma Tadahiko Ito Masahiko Ando

Fossa ovalis

Foramen ovale (heart)

Septum secundum

Primary interatrial foramen

Foramen

Interatrial septum

10.1203/00006450-199212000-00008

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Citations (14)

Severe pulmonary hypertension in an infant with achondroplasia

The Lancet (2001)

Tadahiko Ito Yukio Sawaishi Yasunobu Ito Atsushi Sugawara

Right ventricular hypertrophy

Right-to-left shunt

Nasal cannula

10.1016/s0140-6736(01)06184-0

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Citations (7)

Transcatheter embolization of pulmonary collaterals using liquified gelatin

Pediatrics International (2003)

Tadahiko Ito Toshifumi Suzuki

General hospital

10.1046/j.1442-200x.2003.01759.x

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Citations (1)

Changes in Left Ventricular Diastolic Filling Patterns before and after the Closure of the Ductus Arteriosus in Very-Low-Birth Weight Infants.

The Tohoku Journal of Experimental Medicine (1997)

Masamichi Tamura Kenji Harada Yasushi Takahashi Tadahiko Ito Manatomo Toyono

To evaluate serial changes in left ventricular diastolic filling patterns in preterm infants, we performed echocardiographic examinations in 18 very-low-birth weight infants and 20 fullterm infants before and after the closure of the ductus arteriosus. In the fullterm infants, the ductal closure induced significant decreases in the peak velocity and flow velocity integral of early diastole, first third filling fraction, and mitral stroke volume. In the preterm infants, by contrast, there were significant increases in the flow velocity integral of early diastole, first third filling fraction, and mitral stroke volume after the ductal closure. No differences following the ductal closure were found in the atrial phase of filling and peak filling rate normalized to stroke volume in either group. When the ductus arteriosus was open, essentially the same left-to-right shunting of the ductus arteriosus was detected in both preterm and fullterm infants, but the Doppler flow patterns of the patent foramen ovale were different: the fullterm infants had a single flow peak mainly during ventricular late systole and early diastole, but the preterm infants had two or three flow peaks with nearly equal amplitudes lasting from ventricular systole to diastole, which resembled the Doppler flow pattern of atrial septal defect. Only a faint Doppler flow signal of the foramen ovale was observed after the ductus arteriosus closed. Our results obtained from the preterms suggest that the left-to-right shunt through the foramen ovale may be one important factor to alter the Doppler transmitral filling patterns during the fetal to neonatal cardiovascular changes.

Ductus arteriosus

Foramen ovale (heart)

Shunting

Cardiac cycle

10.1620/tjem.182.337

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Citations (4)

Morphological maturation of left ventricle in fetal rats: changes in left ventricular volume, mass, wall thickness, and mitral valvular size

Early Human Development (1998)

Tadahiko Ito Tomomi Orino Kenji Harada Goro Takada

Volume overload

Afterload

10.1016/s0378-3782(98)00042-5

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Citations (3)

Achondroplasia associated with Foramen Magnum Stenosis : Report of Two Cases

Japanese Journal of Neurosurgery (2003)

Hidehiko Shoji Yasunobu Ito Kazuo Mizoi Atushi Sugawara Tadahiko Ito

軟骨無形成症の2小児例を経験した.症例1:2歳,男児.MRIで大後頭孔部狭窄,脊髄空洞症を合併したキアリI型奇形が指摘され,大後頭孔減圧術,CIの椎弓切除を施行した.術後の経過は順調で,歩行障害は改善した.症例2:1歳,男児.MRIで大後頭孔狭窄による延髄の圧迫を認め,大後頭孔減圧術を施行した.術後,合併していた肺高血圧は改善し,呼吸機能は改善していたが,1年11ヵ月後に肺炎を併発し死亡した.軟骨無形成症は頭蓋頸椎移行部の狭窄を高率に合併し,乳幼児例では呼吸障害を併発し,致死的になることがある.症状が軽微でも,頭蓋頸椎移行部に高度狭窄がみられる患児では,手術的治療を考慮すべきである.

Achondroplasia

Foramen magnum

10.7887/jcns.12.707

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Citations (0)

Acute Disseminated Encephalomyelitis Developed after Acute Herpetic Gingivostomatitis

The Tohoku Journal of Experimental Medicine (2000)

Tadahiko Ito Arata Watanabe Jinzo Akabane

A child with acute disseminated encephalomyelitis (ADEM) developed after acute herpetic gingivostomatisis was described. Inspite of the improvement of his gingivostomatitis, his consciousness gradually deteriorated and he was admitted to Nakadori General Hospital. His consciousness level was drowsiness and increased bilateral patellar reflexes were shown. Because magnetic resonance imaging (MRI) T2-weighted scan showed areas of high signal intensity disseminated in superior portion of medulla oblongata, dorsal portion of pons, basal nuclei and thalamus, he was suspected as having ADEM. Anti-herpes simplex virus (HSV) 1 IgG and IgM antibodies elevated in both blood and cerebrospinal fluid. From these results, HSV1 infection was thought to be the preceding infection of ADEM. Methylprednisolone therapy (20 mg/kg daily) for 3 days, followed by prednisolone (2 mg/kg) was started, with an excellent response. In addition, administration of acyclovir was also continued, considering the complication of HSV encephalitis. MRI T2-weighted scan performed at 2 months later after the onset of ADEM revealed disappearance of the lesions. He was discharged without remaining disorders. It is difficult to distinguish between ADEM and HSV encephalitis because both of these diseases show various neurological symptoms. In our case, MRI was the most useful method for correct diagnosis of ADEM. We concluded that ADEM is important as a disease of central nervus system due to HSV1 infection, in addition to encephalitis.

Acute disseminated encephalomyelitis

Pons

Encephalomyelitis

10.1620/tjem.192.151

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Citations (16)

Role of age on transmitral flow velocity patterns in assessing left ventricular diastolic function in normal infants and children

The American Journal of Cardiology (1995)

Kenji Harada Takashi Suzuki Masamichi Tamura Tadahiko Ito Yasushi Takahashi

10.1016/s0002-9149(99)80148-9

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Citations (50)