ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHighly flexible chelating ligands for Group 13 metals: design and synthesis of hexadentate (N3O3) tripodal amine phenol ligand complexes of aluminum, gallium, and indiumShuang Liu, Ernest Wong, Veranja Karunaratne, Steven J. Rettig, and Chris OrvigCite this: Inorg. Chem. 1993, 32, 9, 1756–1765Publication Date (Print):April 1, 1993Publication History Published online1 May 2002Published inissue 1 April 1993https://pubs.acs.org/doi/10.1021/ic00061a036https://doi.org/10.1021/ic00061a036research-articleACS PublicationsRequest reuse permissionsArticle Views466Altmetric-Citations49LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
A new series of linear N4O2 amine phenols (H2badd, H2Brbadd, and H2Clbadd) based on N,N'-bis(3-aminopropyl)ethylenediamine (tnentn) were prepared and characterized by spectroscopic techniques. Monocationic hexadentate metal complexes with the tnentn-based amine phenols were obtained from the reactions of Ga3+ and In3+ with the linear amine phenol in the presence of a weak base (acetate). The molecular structure of [Ga(Brbadd)]ClO4 has been determined by X-ray crystallography; crystals of [Ga(Brbadd)][ClO4] (C22H30Br2ClGaN4O6) are orthorhombic: a = 12.462(1) Å, b = 21.835(2) Å, c = 9.961(2) Å, Z = 4, space group P212121. The structure was solved by the Patterson method and was refined by full-matrix least-squares procedures to R = 0.031 (Rw = 0.029) for 1924 reflections with I ≥ 3σ(I). The Ga3+ ion is coordinated in a distorted octahedral geometry by an N4O2 donor atom set. The four nitrogen atoms of the tetraamine backbone form the equatorial plane of the octahedron, and the two phenolate oxygen atoms are coordinated trans to each other. Water-soluble 1,10-bis(2-hydroxy-5-sulfonylbenzyl)-1,4,7,10-tetraazadecane (H6Sbad2+), 1,12-bis(2-hydroxybenzyl-5-sulfonylbenzyl)-1,5,8,12-tetraazadodecane (H6Sbadd2+), and N,N'-bis-(2-hydroxy-5-sulfonylbenzyl)-N,N'-bis(2-methylpyridyl)ethylenediamine (H6Sbbpen2+) were also prepared and characterized; potentiometric titrations of these three ligands, in the absence and presence of Ga3+ and In3+, were performed to determine deprotonation constants of the ligands and the thermodynamic stabilities of Ga and In amine phenol complexes. The formation constants of the Ga3+ and In3+ complexes with Sbad4- (Ga3+, log β = 28.33(8); In3+, log β = 24.54(2)), Sbadd4- (Ga3+, log β = 28.27(5); In3+, log β = 24.56 (5)), and Sbbpen4- (Ga3+, log β = 35.33(8); In3+, log β = 34.85(5)) were obtained. All six of the Ga and In hexadentate amine phenol complexes were found to be very stable in aqueous solution. With the exception of [In(Sbadd)]-, all the complexes were calculated to be thermodynamically stable with respect to demetalation by transferrin at physiological pH. The linear amine phenols showed a selectivity for Ga3+ over In3+, while the Sbbpen4- derivative was indiscriminate in binding the Ga3+ and In3+ ions.
The Tc-99m complex of dimethylglycyl-l-seryl-l-cysteinyl(acm)-glycl-l-threonyl-l-lysyl-l-prolyl-l-prolyl-l-arginine (RP128) is a radiopharmaceutical designed for imaging sites of inflammation. RP128 and its rhenium(V) and technetium(V) oxo complexes were prepared and characterized by HPLC and various spectroscopic techniques. Analysis of RP128 showed that the attachment of the dimethylglycyl-l-seryl-l-cysteinyl-glycine sequence and the coordination of it to a TcO3+ core did not affect the threonyl-l-lysyl-l-prolyl-l-prolyl-l-arginine (TKPPR) portion of the molecule in aqueous solution.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTGallium and Indium Complexes of Hexadentate Ligands Containing Pendant Pyridyl and Phenolate GroupsErnest Wong, Shuang Liu, Steve Rettig, and Chris OrvigCite this: Inorg. Chem. 1995, 34, 11, 3057–3064Publication Date (Print):May 1, 1995Publication History Published online1 May 2002Published inissue 1 May 1995https://pubs.acs.org/doi/10.1021/ic00115a036https://doi.org/10.1021/ic00115a036research-articleACS PublicationsRequest reuse permissionsArticle Views827Altmetric-Citations34LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTComplexes of Trivalent Metal Ions with Potentially Heptadentate N4O3 Schiff Base and Amine Phenol Ligands of Varying RigidityLi-Wei Yang, Shuang Liu, Ernest Wong, Steven J. Rettig, and Chris OrvigCite this: Inorg. Chem. 1995, 34, 8, 2164–2178Publication Date (Print):April 1, 1995Publication History Published online1 May 2002Published inissue 1 April 1995https://doi.org/10.1021/ic00112a032RIGHTS & PERMISSIONSArticle Views722Altmetric-Citations79LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (2 MB) Get e-AlertsSupporting Info (4)»Supporting Information Supporting Information Get e-Alerts
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHexadentate N3O3 amine phenol ligands for Group 13 metal ions: evidence for intrastrand and interstrand hydrogen-bonds in polydentate tripodal amine phenolsShuang Liu, Ernest Wong, Steven J. Rettig, and Chris OrvigCite this: Inorg. Chem. 1993, 32, 20, 4268–4276Publication Date (Print):September 1, 1993Publication History Published online1 May 2002Published inissue 1 September 1993https://doi.org/10.1021/ic00072a019RIGHTS & PERMISSIONSArticle Views197Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-AlertsSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Neutral Re(V) and Tc(V) oxo complexes of the peptide dimethylglycyl-L-seryl-L-cysteinylglycinamide (RP294) were prepared and characterized by HPLC, spectroscopic techniques, and X-ray crystallographic analysis. The peptide was prepared as a single peptide chain using solid phase methods and characterized by HPLC and various spectroscopic techniques. The water-soluble Re(V) oxo complex of dimethylglycyl-L-seryl-L-cysteinylglycinamide [ReO(RP294)] was prepared from the reaction of the peptide with either [ReO(2)(en)(2)]Cl or ReOCl(3)(PPh(3))(2) in the presence of base. The complex exists as two isomers, the serine CH(2)OH group being in the syn oranti conformation with respect to the Re-oxo bond. The ratio of the isomers at room temperature is 1:1.1. The isomers were separated by reverse-phase HPLC, but the isolation of each isomer was complicated by their rapid interconversion in aqueous solution at room temperature. The molecular structure of the syn isomer of the Re complex was determined by X-ray crystallography. Crystals of syn-[ReO(RP294)] (C(12)H(20)N(6)O(5)ReS) are orthorhombic, of space group P2(1)2(1)2(1), with a = 6.954(1) Å, b = 8.0472(1) Å, c = 32.9183(4) Å, and Z = 4. The structure was solved by direct methods and was refined by full-matrix least-squares procedures to R = 0.0327 (R(w) = 0.0838) for 10 447 reflections with I > 2sigma(I). The Re metal was coordinated in a distorted square pyramidal geometry with the oxo moiety in the apical position. The peptide coordinated to ReO(3+) via the N(amine) atom of dimethylglycine, the S(thiolate) atom of cysteine, and the two N(amide) atoms of serine and cysteine (an N(2)N'S donor atom set). The Re atom lies approximately 0.74 Å above the distorted plane formed by the N(2)N'S donor atom set. Variable-pH (1)H NMR spectral data showed the Re complex was stable from pH 5 to 8.5. The reaction of (99)TcO(4)(-) with SnCl(2), sodium gluconate, and RP294 produced the (99)Tc(V) oxo RP294 complex, [(99)TcO(RP294)]. Like the [ReO(RP294)] complex, [(99)TcO(RP294)] also exists in the syn and anti conformations in a ratio of approximately 1:1. The (99m)Tc complex of RP294 was prepared at the tracer level from the reaction of Na[(99m)TcO(4)] with excess SnCl(2), sodium gluconate, and RP294. The (99m)Tc and Re RP294 complexes behaved similarly under identical HPLC conditions.
