Fred Hancock

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

Transfer hydrogenation

10.1002/chin.200706045

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[2.2]Paracyclophane-based monophosphine ligand for palladium-catalyzed cross-coupling reactions of aryl chlorides

Organic & Biomolecular Chemistry (2009)

Jiwu Ruan Lee Shearer Jun Mo John Bacsa Antonio Zanotti‐Gerosa

A new [2.2]paracyclophane-based electron-rich and sterically bulky monophosphine ligand has been synthesized by an efficient and straightforward method. When combined with palladium, this ligand shows excellent performance in the Buchwald-Hartwig amination and Suzuki-Miyaura coupling reactions of various aryl chlorides. In both types of reactions, ortho-substituted, deactivated aryl chlorides are shown to be viable substrates. However, the Suzuki-Miyaura coupling appears to be easier, with palladium loading at 0.1 mol% being feasible.

Coupling reaction

10.1039/b906139h

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Citations (29)

Rapid identification of cytochrome P450cam variants by in vivo screening of active site libraries

Tetrahedron Asymmetry (2004)

Robert Speight Fred Hancock Chris Winkel Hanamanthsa S. Bevinakatti Manish Sarkar

Hydroxylation

10.1016/j.tetasy.2004.06.053

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Citations (14)

Catalytically enhanced absorption of sulphur species from odorous air streams: A new technology for odour abatement

Catalysis Today (1998)

Fred Hancock Frank D. King Wendy R. Flavell M. Saïful Islam

Data scrubbing

Claus process

10.1016/s0920-5861(98)00058-3

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Citations (9)

Catalysis in Water: A Viable Alternative for Asymmetric Transfer Hydrogenation of Ketones

ChemInform (2007)

Jianliang Xiao Xiaofeng Wu Antonio Zanotti‐Gerosa Fred Hancock

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

Transfer hydrogenation

10.1002/chin.200727248

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Citations (2)

Rapid identification of cytochrome P450cam variants by in vivo screening of active site libraries

Robert Speight Fred Hancock Chris Winkel Hanamanthsa S. Bevinakatti Manish Sarkar

Hydroxylation

Identification

Primary (astronomy)

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Citations (0)

The effect of grape variety and smoking duration on the accumulation of smoke taint compounds in wine

Wine & viticulture journal (2013)

Nicole Cain Fred Hancock Peter L. Rogers Mark O. Downey

Source

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Citations (2)

Ruthenium-Catalysed Asymmetric Reduction of Ketones

Platinum Metals Review (2005)

Antonio Zanotti‐Gerosa William P. Hems Michelle Groarke Fred Hancock

The asymmetric reduction of carbonyl, C=O, groups for the production of enantiomerically pure secondary alcohols is a reaction of fundamental importance in modern synthetic chemistry. This reaction can be performed in a number of ways. Asymmetric chemocatalysis (1) and the often complementary biocatalysis offer solutions to the stereoselective reduction of C=O groups. These two techniques have found wide industrial application (2). In the mid 1990s, two new ruthenium systems based on dihydrogen or transfer hydrogenation for asymmetric reduction of prochiral ketones were developed by Professors Noyori and Ikariya. These systems enable catalytic asymmetric reduction to provide a route for the generation of enantiomerically pure secondary alcohols in a highly efficient, simple and economic way (3). This paper describes some robust and cost-effective chemocatalytic technology for asymmetric ketone reduction, using ruthenium catalysts with diphosphine ligands.

10.1595/147106705x75421

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Citations (52)

Ruthenium-Catalysed Asymmetric Reduction of Ketones DIPHOSPHINE LIGANDS IN HYDROGENATIONS FOR PHARMACEUTICAL SYNTHESIS

Antonio Zanotti‐Gerosa William P. Hems Michelle Groarke Fred Hancock

The asymmetric reduction of carbonyl, C=O, groups for the production of enantiomerically pure secondary alcohols is a reaction of fundamental importance in modern synthetic chemistry. This reaction can be performed in a number of ways. Asymmetric chemocatalysis (1) and the often complementary biocatalysis offer solutions to the stereoselective reduction of C=O groups. These two techniques have found wide industrial application (2). In the mid 1990s, two new ruthenium systems based on dihydrogen or transfer hydrogenation for asymmetric reduction of prochiral ketones were developed by Professors Noyori and Ikariya. These systems enable catalytic asymmetric reduction to provide a route for the generation of enantiomerically pure secondary alcohols in a highly efficient, simple and economic way (3). This paper describes some robust and cost-effective chemocatalytic technology for asymmetric ketone reduction, using ruthenium catalysts with diphosphine ligands.

Transfer hydrogenation

Noyori asymmetric hydrogenation

Asymmetric hydrogenation

Biocatalysis

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Citations (4)

Oxazaphospholidine-oxide as an Efficient ortho-Directing Group for the Diastereoselective Deprotonation of Ferrocene

Organic Letters (2005)

Daniele Vinci Nuno Mateus Xiaofeng Wu Fred Hancock Alexander Steiner

[reaction: see text] Ortho-lithiation of (2R,4S,5R)-3,4-dimethyl-2-ferrocenyl-5-phenyl[1,3,2]oxazaphospholidine 2-oxide 2 was carried out with diastereoselectivity of >99%, affording a new and efficient way for introducing planar chirality into the ferrocene backbone. Various electrophiles were used to quench the lithiated species, showing the wide applicability of the new ortho-directing group and its potential to generate ligands for use in asymmetric catalysis.

Chirality

Planar chirality

10.1021/ol0523704

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Citations (64)

Papers

Citation

H-Index

i-10 index

Papers

Citation

H-Index

i-10 index