Abstract Several new thiazoles ( 3–7 ), thiazolylpyrazole carbonitrile ( 10 , 11 ), and Thiazolidine sulfonamido conjugate derivatives ( 19–26 ) were prepared starting with p-Piperidinesulfonylacetophenones ( 1 , 2 ). The structure of these compounds was elucidated on the bases of elemental analysis, IR, PMR, and mass spectra. The antimicrobial activities of some selected compounds are also reported. Keywords: p-Piperidinesulfonylacetophenonesthiazolethiazolidine-containing piperidine sulfonamidethiazolylpyrazol

Thiazolidine

Thiazole

Conjugate

Piperidine

10.1080/10426500490475049

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Citations (8)

Studies on Thiazolopyridines. Part 4: Synthesis of Hitherto Unknown 1,4-Bis(thiazolopyridine)benzene Derivatives

Phosphorus, sulfur, and silicon and the related elements (2003)

M. S. A. El‐Gaby M. M. Khafagy Gameel A. M. El‐Hag Ali Hassan A. Eyada A. A. EL‐MAGHRABY

2-Cyanomethyl-4-thiazolinone ( 1 ) was condensed with terephthalaldehyde ( 2 ) (2:1 molar ratio) and produced 1,4-bis(2-cyanomethyl-4,5-dihydro-5-methylidene-4-thiazolinone-5-yl) benzene ( 3 ). Treatment of compound ( 3 ) with benzylidenemalononitrile ( 4 ) (1:2 molar ratio) furnished the novel bisthiazolopyridines ( 6a-e ). Condensation of compound ( 1 ) with aromatic aldehyde yielded the benzylidene derivatives ( 7a-f ), which on treatment with compound ( 8 ) (2:1 molar ratio) afforded the novel bisthiazolopyridines ( 10a-f ). Structures of the synthesized compounds have been established by elemental analyses and spectral data.

Molar ratio

Condensation reaction

10.1080/10426500307827

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Citations (8)

Synthesis of New 2-Substituted-pyrazolo[4',3':5,6]pyrano[3,2-e][1,2,4]triazolo[ 1,5 -c ]pyrimidine Derivatives

Zenodo (CERN European Organization for Nuclear Research) (1997)

Saber M. Hassan M. M. Khafagy Hussein A. Emam A. A. EL‐MAGHRABY

10.5281/zenodo.5876741

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Citations (6)

p-Chlorosulphonate-O-Toluic Acid Azide and its Urea and Urethan Derivatives

Oriental Journal Of Chemistry (2018)

Hassan A. Eyada M. T. Shehata Hussein A. Emam M. M. Khafagy

Elsevier Biobase

Industrial chemistry

Coordination complex

Material chemistry

GEOBASE

Radiation chemistry

Food chemistry

FLUIDEX

Source

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Citations (0)

ChemInform Abstract: Synthesis of New 2‐Substituted‐pyrazolo[4′,3′:5,6]pyrano[3,2‐e][1,2,4]triazolo [1,5‐c]pyrimidine Derivatives.

ChemInform (1998)

Saber M. Hassan M. M. Khafagy H. A. EMAN A. A. EL‐MAGHRABY

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

10.1002/chin.199826192

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Citations (1)

Studies on Thiazolopyridines. Part 5. Synthesis of Hitherto Unknown Thiazolinone and Thiazolo[3,2‐a]pyridine Derivatives Having in Their Structure the Morpholin‐4‐yl Moiety.

ChemInform (2004)

R. Q. Lamphon M. S. A. El‐Gaby M. M. Khafagy Gameel A. M. El‐Hag Ali A. A. EL‐MAGHRABY

Moiety

10.1002/chin.200451039

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Citations (0)

STUDIES ON THIAZOLOPYRIDINES. PART 5: SYNTHESIS OF HITHERTO UNKNOWN THIAZOLINONE AND THIAZOLO[3,2-a]PYRIDINE DERIVATIVES HAVING IN THEIR STRUCTURE THE MORPHOLIN-4-YL MOIETY

Phosphorus, sulfur, and silicon and the related elements (2004)

R. Q. Lamphon M. S. A. El‐Gaby M. M. Khafagy Gameel A. M. El‐Hag Ali A. A. EL‐MAGHRABY

Condensation of thiazolinone 1 with benzaldehydes 2a, b in ethanolic piperidine afforded the methylidene derivatives 3a, b. Cyclocondensation of compound 3b with malononitrile furnished the novel thiazolo[3,2-a]-pyridine 5. Also, compound 3b was condensed with dimethylformamide-dimethylacetal (DMF-DMA) and triethylortho-formate to yield N,N-dimethylamino 6 and ethoxymethylene 7 derivatives respectively. The novel thiazolo[3,2-a]pyridines 10a, b were obtained by cyclocondensation of compounds 3a, b with benzylidene-malononitriles 8a, b. Similarly, cyclocondensation of compound 3b with benzylidenemalononitrile 11 afforded the thiazolopyridines 12a–c. Ternary condensation of compound (12), 4-morpholinobenzaldehyde 2b and malononitrile (1:1:1 molar ratio) produced the thiazolopyridines 14a–c. When compound 10b was subjected to react with malononitrile in dioxane/piperidine under reflux the novel condensed heterocyclic system 18 was obtained. Treatment of ortho-aminocarbonitrile 10b with formic acid, aromatic aldehyde and triethylorthoformate furnished the thiazolo[2′,3′:1,6] pyrido[2,3-d] pyrimidine 20, azomethine 21a, b and ethoxymethylene 22 derivatives respectively. The structure of the synthesized compounds was established by analytical and spectral data.

Piperidine

Moiety

Dimethyl formamide

10.1080/10426500490468092

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Citations (16)

Synthesis and Reactions of Some New Diiodocoumarin Derivatives Bearing Side Chains and Some of Their Biological Activities

American Journal of Chemistry (2012)

Ashraf Hassan Fekry Abd El‐Wahab Hany M. Mohamed Ahmed M. El‐Agrody Ahmed H. Bedair F. Eid

The synthesis of 6,8-diiodocoumarin derivatives (2-6) by condensation of 3,5-diiodosalicylaldehyde (1) with active methylene compounds is described. Reaction of 6 with malononitrile afforded two products pyridine and ethylidine malononitrile derivatives (7, 8), while treatment of 6 with p-methoxybenzylidenemalononitrile in absolute ethanol/piperdine provided pyrane and bis coumarin derivatives (9,10). Reaction of 6 with DMF/POCl₃ afforded three products coumarin derivatives (11,12,13), while bromination of 6 with Br₂/AcOH gave 3-bromo-6,8-diiodocoumarin (14). Treatment 6 with aromatic aldehydes gave the corresponding 3-(3-arylacryloyl)-6,8-diiodocoumarin derivatives (16a,b) while reaction of 6 with aniline or phenylhydrazine gave coumarin derivatives 17 and 18. Reaction of 18 with DMF/POCl₃ gave pyrazole-4-aldehyde derivative (19). Condensation of 19 with active methylene compounds afforded pyrazole and pyrimidine derivatives (20a-c) and 21). Reaction of 8 with sulphur via the Gewald reaction afforded thiophene derivative (22), while the reaction of 8 with p-methoxybenzylidenemalononitrile gave biphenyl derivative (23). Treatment of 8 with chloroacetyl chloride afforded the furan derivative (24). The structures of the newly synthesized compounds were confirmed by IR, ¹H NMR and ¹³C NMR and mass spectral data. The newly synthesized compounds were also screened for their antimicrobial activity.

Methylene

Knoevenagel condensation

Condensation reaction

Pyrazole

10.5923/j.chemistry.20110101.01

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Citations (14)

Synthesis and antimicrobial evaluation of naphtho[2,1-b]pyrano[2,3-d]pyrimidine and pyrano[3,2-e][1,2,4]triazolo[1,5-c]pyrimidine derivatives.

PubMed (2004)

F. Eid Ashraf Hassan Fekry Abd El‐Wahab Gameel A. M. El‐Hag Ali M. M. Khafagy

Several novel naphtho[2,1-b]pyrano[2,3-d]pyrimidines, pyrano[3,2-e][1,2,4]triazolo[1,5-c]pyrimidines and their coumarin-3-yl derivatives were synthesized. Some of these derivatives exhibited pronounced antimicrobial activities.

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Citations (65)