B.E. Buck

National Center for Immunization and Respiratory Diseases

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Theodore I. Malinin

University of Miami

Neal S. Penneys

Saint Louis University

Recia Kott‐Blumenkranz

University of Miami

Violet Esquenazi

University of Miami

Wade P. Parks

University of Pittsburgh

David Roth

University of Miami

Angelo de Mattos

Oregon Health & Science University

Sharon Babischkin

University of Miami

Mehrdad Nadji

Sylvester Comprehensive Cancer Center

H. Thomas Temple

University of Miami

Cooperative Institutions

University of Miami

Centers for Disease Control and Prevention

University of California, Irvine

Florida Department of Health

National Center for Immunization and Respiratory Diseases

Jackson Memorial Hospital

University of Pennsylvania

Memorial Medical Center

Miami VA Healthcare System

Miami Transplant Institute

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Bone Transplantation and Human Immunodeficiency Virus

Clinical Orthopaedics and Related Research (1989)

B.E. Buck Theodore I. Malinin Mark D. Brown

The possibility of transplanting a bone allograft from a donor infected with human immunodeficiency virus (HIV) is remote, provided there is a combination of rigorous donor selection and exclusion, screening for the HIV antigen and antibody, and histopathologic studies of donor tissues. The chance of obtaining a bone allograft from an HIV-infected donor who failed to be excluded by the above techniques is calculated to be one in well over a million, using average estimates. On the other hand, if adequate precautions are not taken (for example, by testing only for antibodies to HIV), the risk might be as high as one in 161.

10.1097/00003086-198903000-00015

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Citations (545)

S100‐Protein‐Containig Dendritic Cells in Fetal and Newborn Epidermis and Thymus

Pediatric Dermatology (1986)

Neal S. Penneys Recia Kott‐Blumenkranz B.E. Buck Mehrdad Nadji E Gould

Abstract: Skin and thymus were obtained from abortuses of varying ages and from neonatal autopsies to determine if SlOO‐protein‐containing dendritic cells were present. Using an unlabeled antibody peroxidase‐antiperoxidase method, we could not detect these dendritic cells in epidermis prior to live birth, but did detect them at all fetal ages in thymus. Within 24 hours of live, full‐term delivery, dendritic cells containing SI00 protein were identified in epidermis.

Epidermis (zoology)

S100 protein

10.1111/j.1525-1470.1986.tb00518.x

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Citations (6)

Pan-nephric candidial abscesses

Urology (1978)

William J. Cromie B.E. Buck

10.1016/0090-4295(78)90107-3

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Citations (5)

Concurrent Outbreaks of Hepatitis A, Invasive Meningococcal Disease, and Mpox, Florida, USA, 2021–2022

Emerging infectious diseases (2024)

Timothy J. Doyle Megan Gumke Danielle Stanek Joshua Moore B.E. Buck

Abstract In 2022, concurrent outbreaks of hepatitis A, invasive meningococcal disease (IMD), and mpox were identified in Florida, USA, primarily among men who have sex with men. The hepatitis A outbreak (153 cases) was associated with hepatitis A virus genotype IA. The IMD outbreak (44 cases) was associated with Neisseria meningitidis serogroup C, sequence type 11, clonal complex 11. The mpox outbreak in Florida (2,845 cases) was part of a global epidemic. The hepatitis A and IMD outbreaks were concentrated in Central Florida and peaked during March–June, whereas mpox cases were more heavily concentrated in South Florida and had peak incidence in August. HIV infection was more common (52%) among mpox cases than among hepatitis A (21%) or IMD (34%) cases. Where feasible, vaccination against hepatitis A, meningococcal disease, and mpox should be encouraged among at-risk groups and offered along with program services that target those groups.

10.3201/eid3004.231392

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Citations (5)

[Congenital embryonal rhabdomyosarcoma of the head in a red and white German Holstein calf].

PubMed (2014)

Reiner Ulrich B.E. Buck O. Distl Peter Wohlsein

Tumours with skeletal-muscle differentiation are rare in companion animals. They are differentiated into benign rhabdomyomas and malignant rhabdomyosarcomas. A female German Holstein calf displayed a congenital, spherical, subcutaneous mass at the lateral side of the head. Histology revealed an encapsulated, expansile, highly cellular mass consisting of a reticular meshwork of moderately pleomorphic, small spindle-shaped to round cells within a fibrovascular to myxoid stroma as well as multifocal, large, blunt, multinucleated myotube-like cells (strap cells). Electron microscopy demonstrated characteristic cytoplasmic bundles of myofilaments and Z-stripes within the strap cells. Immunoreactivity for vimentin was observed in the small spindle-shaped cells and for desmin in the strap cells. The results are consistent with the spectrum of findings characteristic for a bovine congenital embryonal rhabdomyosarcoma.

Desmin

Embryonal rhabdomyosarcoma

Multinucleate

Reticular connective tissue

Histology

Myofibroblast

Reticular cell

Reticular fiber

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Citations (4)

Frozen section differentiation of drug-induced and staphylococcalinduced toxic epidermal necrolysis

The Journal of Pediatrics (1978)

Paul J. Honig Allan Gaisin B.E. Buck

Toxic Epidermal Necrolysis

Section (typography)

10.1016/s0022-3476(78)80460-0

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Citations (10)

Human Immunodeficiency Virus Cultured From Bone

Clinical Orthopaedics and Related Research (1990)

B.E. Buck Lionel Resnick Shabir Shah Theodore I. Malinin

This study demonstrates by a virologic culture method that human immunodeficiency virus (HIV) resides in bone. After freezing, some initially positive specimens no longer yielded virus, but those that continued to yield virus were not further altered by subsequent washing, which removed essentially all marrow, or by freeze-drying. The safeguards against potential transmission of HIV by a bone allograft are principally the screening and testing methods previously described, although there may be a further reduction of the remote residual risk by the freezing step in the usual technical sequence for tissue banking by sterile techniques.

Human bone

10.1097/00003086-199002000-00042

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Citations (215)

Transmission of Histoplasmosis by Organ Transplantation

New England Journal of Medicine (2001)

B.E. Buck Theodore I. Malinin Jeffrey Davis

Disease Transmission

10.1056/nejm200101253440417

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Citations (7)

Iron Overload Hepatotoxicity: A Postulated Pathogenesis

Clinical toxicology (1971)

C.L. Witzleben B.E. Buck

(1971). Iron Overload Hepatotoxicity: A Postulated Pathogenesis. Clinical Toxicology: Vol. 4, No. 4, pp. 579-583.

Pathogenesis

10.3109/15563657108990980

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Citations (10)

Incidence of clostridial contamination in donors’ musculoskeletal tissue

Journal of Bone and Joint Surgery - British Volume (2003)

Theodore I. Malinin B.E. Buck H. Thomas Temple Octavio Martínez William P. Fox

Reports of infection by Clostridium sordellii associated with allograft transplantation have generated considerable interest. We report our experience in recognising clostridial contamination in cadaver donors of musculoskeletal tissue. Tissues obtained from 795 consecutive donors were excised using standard surgical techniques. Samples of blood and bone marrow were also obtained. Donors with clostridia recovered from any site were matched with the preceding donor without clostridia as a procedural and environmental control. The histories of the donors were analysed to determine which variables had a relationship to contamination by running a contingency table and chi-squared test on the variables against the event of a donor being contaminated. Sixty-four donors (8.1%) had clostridia, most commonly C. sordellii. Clostridia were grown from the blood, marrow and tissue samples of 52, 37 and 30 donors, respectively. In eight cases, they were cultured from the tissue samples alone. There was no significant difference in age or gender between the contaminated donors and the control group. Open wounds were more common in control than in contaminated subjects, but only death by drowning in the contaminated group was statistically significant (p = 0.02). The time between death and the excision of tissue which was contaminated (16 hrs 10 mins) compared with control (11 hrs 10 mins) donors was also significant (p < 10(-6)). We conclude that there is clostridial contamination in a significant number of tissue donors, particularly with increasing time between death and tissue excision. Among the most commonly encountered species is C. sordellii. Multiple microbiological cultures, including blood, are necessary in order to identify clostridial contamination.

Clostridia

10.1302/0301-620x.85b7.14438

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Citations (66)