Objectives. Superoxide dismutase, acting as a scavenger of oxygen free radicals, has shown mixed results in increasing survival from burn wounds. We previously demonstrated that human recombinant copper-zinc superoxide dismutase could increase the survival of failing ischaemic flaps in a rat model. Because of the similar pathophysiology of tissue ischaemia in flaps and intermediate zone burns, we conducted a later study employing two groups of rats with standardized intermediate burns, to ascertain whether or not human recombinant copper-zinc superoxide dismutase could increase intermediate burn zone survival in rats. The results showed that post-burn human recombinant copper-zinc superoxide dismutase failed to improve intermediate burn zone survival. We decided to undertake a new study to ascertain whether there was a protective effect of human recombinant copper-zinc superoxide dismutase in intermediate burns. Methods. This controlled study employed two groups of rats, one of which received prophylactic treatment with human recombinant copper-zinc superoxide dismutase before the induction of standardized intermediate burns. Results. The results showed that pre-burn human recombinant copper-zinc superoxide dismutase also failed to improve intermediate burn zone survival. Conclusions. Further studies are needed to fully understand the effect of oxygen free radicals in burn wound pathophysiology and to determine whether human recombinant copper-zinc superoxide dismutase has a place in the clinical management of burns.

Dismutase

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Citations (3)

Periodic Migrainous Neuralgia

BMJ (1964)

A. Shalom

10.1136/bmj.1.5383.633-b

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Citations (1)

Pain in the face.

BMJ (1968)

A. Shalom

psychosomatic diseases " have emotional sensitivity as their common property, and determinable specific sensitivities are found in most of them.The environment does the rest.-Iam, etc., RANYARD WEST.Church Stretton, Salop.Side-effects of Vinca Alkaloids SIR,-The findings by Dr. A. Vladutiu (22 June, p. 764) of acute dilatation of the gut in guinea-pigs receiving intraperitoneal injections of vinblastine is similar to the ex- perience of others working with this drug.Constipation, abdominal distension, and pain, sometimes sufficient to precipitate laparo- tomy, as well as acute urinary retention and loss of salivation, occasionally occur in patients receiving vinblastine,' 2 though the incidence of these complications is far greater in patients receiving the closely related alka- loid, vincristine.'' Prophylactic bulk laxa- tives and other aperients are recommended routinely for patients receiving vincristine.'Smith' found similar acute dilatation of the gut in mice treated with intraperitoneal injections of vinblastine, and moreover demonstrated degenerative changes in the myenteric plexus of the gut both in man and the mouse.This finding is in keeping with the known neurotoxicity of vinblastine, but more particularly of vincristine.'Almost certainly direct damage to the myenteric plexus causes paralysis of the gut.There is no evidence for the true ganglion-blocking action of vinblastine suggested by Dr.

10.1136/bmj.3.5609.58-b

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Treatment of Hypertrophic Granulation Tissue with Topical Steroids

Journal of Burn Care & Rehabilitation (2003)

A. Shalom L. Wong

Journal Article Treatment of Hypertrophic Granulation Tissue with Topical Steroids Get access A. Shalom, MD, A. Shalom, MD 1Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Israel, Zerifin, Israel2University of Tennessee, Chattanooga, TN Search for other works by this author on: Oxford Academic Google Scholar L. Wong, MD, FACS L. Wong, MD, FACS 1Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Israel, Zerifin, Israel2University of Tennessee, Chattanooga, TN Search for other works by this author on: Oxford Academic Google Scholar The Journal of Burn Care & Rehabilitation, Volume 24, Issue suppl_2, March-April 2003, Page S113, https://doi.org/10.1097/00004630-200303002-00141 Published: 01 March 2003

Granulation tissue

Granulation

10.1097/00004630-200303002-00141

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Full-thickness burns across joints: results of coverage with acellular dermal matrix and thin autograft

European Journal of Plastic Surgery (2005)

A. Shalom L. Wong Andrew M. Munster

Skin grafting

10.1007/s00238-005-0723-5

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