Nancy Youssef Asaad

Menoufia University

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Asmaa Gaber Abdou

Menoufia University

Moshira Mohammed Abd El-Wahed

Menoufia University

Rehab Monir Samaka

Menoufia University

Shereen Fathy Mahmoud

Menoufia University

Marwa Salah Gad Allah

Menoufia University

Doha Maher Taie

Menoufia University

Aiat Shaban Hemida

Menoufia University

Rania Abdallah Abdallah

University of Gezira

Nermin Ehsan

Menoufia University

Mohammad Shaban

Indian Institute of Public Health Gandhinagar

Cooperative Institutions

Menoufia University

Cairo University

October University of Modern Sciences and Arts

Beni-Suef University

Liver Institute Northwest

University of Birmingham

Menoufia University Hospitals

Faculty (United Kingdom)

University of Gezira

King Fahad Hospital Jeddah

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Rheumatoid Nodule of the Vocal Cord

International Journal of Surgical Pathology (2012)

Asmaa Gaber Abdou Nancy Youssef Asaad

Nodule (geology)

10.1177/1066896912448426

Cite

Citations (3)

Intrarenal epidermoid cyst presented as an enlarged multicystic kidney.

PubMed (2010)

Asmaa Gaber Abdou Nancy Youssef Asaad

This report describes a case of large multiple and multilocular epidermoid cysts affecting the left kidney of a 67 old male. The condition was accidentally discovered during the ultrasonography for left loin pain and revealed enlarged left kidney with picture suggestive of hydronephrosis. Grossly, the kidney was distorted cysts that were filled with a cheesy material. The histologic picture of an end stage kidney disease was apparent in the compressed renal parenchyma by these cysts that were identical to an epidermoid cyst elsewhere. In conclusion, although rare, epidermoid cyst of the kidney could cause serious kidney damage leading to an end stage kidney disease. Epidermoid cyst of the kidney could be multiple producing a picture similar to hydronephrosis and broadening the differential diagnosis of multicystic disease of the kidney.

Epidermoid cyst

Source

Cite

Citations (7)

Does Farnesoid X receptor (FXR) Have a Role in NAFLD Progression ?

The Egyptian Journal of Hospital Medicine (2021)

Shereen Fathy Mahmoud Dina Sweed Esraa Karman Nancy Youssef Asaad Nanis Shawky Holah

Background: Non-alcoholic fatty liver disease (NAFLD) is the emerging cause of chronic liver disease.In addition, steatosis may lead to failure of obtaining sustained virological response after hepatitis C virus eradication.Therefore, there is a trend to identify effective strategies for managing hepatic steatosis.Farnesoid X receptor (FXR) agonists are reported to play a role in NAFLD treatment.Objective: This study aimed to explore the immunohistochemical expression of FXR in NAFLD spectrum in association with the clinicopathological data.Material and method: This was a retrospective study including 50 cases of NAFLD and 23 cases of normal liver.The NAFLD group was subdivided into 11 cases of NAFL (simple steatosis) and 39 cases of non-alcoholic steatohepatitis (NASH).Results: Hepatocyte FXR nuclear expression was significantly decreased in NASH group (P=0.001) with no significant decrease in NAFL group compared to normal liver (P=0.149).Bile duct FXR expression was significantly lower in NAFL group compared to normal liver (P= 0.009) to reach the lowest level in NASH group (P= 0.017).In NAFLD group, there was an inverse correlation between hepatocyte FXR nuclear expression and the ALT/AST ratio (r=-0.349and P=0.013).However, hepatocyte FXR nuclear expression was significantly associated with moderate grade of steatosis and severe fibrosis (P= 0.044 and P= 0.033, respectively).Conclusion: Hepatocyte FXR nuclear expression showed a stepwise decrease in its expression from normal to NASH passing with NAFL.Therefore, FXR has a protective role against NAFLD progression.Elevated liver enzymes could be used as a non-invasive method for monitoring FXR agonists' efficacy.

Farnesoid X receptor

Steatosis

Steatohepatitis

10.21608/ejhm.2021.175733

Cite

Citations (1)

Signet Ring Dermatofibroma, a Rare and Confusing Variant

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH (2015)

Asmaa Gaber Abdou Nancy Youssef Asaad

Dermatofibroma is a common cutaneous benign fibrohistiocytic tumour, which is usually diagnosed without difficulty. In this report we demonstrated a signet ring variant of dermatofibroma as a rare variant of this common neoplasm together with the possible differential diagnosis.The presence of signet cells in cutaneous neoplasm does not necessarily means malignancy. Signet ring dermatofibroma is a rare variant eliciting differential diagnostic problems which can be solved by careful histopathological examination, searching for the classic areas and the help of immunohistochemistry.

Dermatofibroma

Neoplasm

10.7860/jcdr/2015/13223.5923

Cite

Citations (0)

Fine Needle Aspiration Cytology of Chondroid Tenosynovial Giant Cell Tumor of the Hand

Rare Tumors (2015)

Asmaa Gaber Abdou Hayam A. Aiad Nancy Youssef Asaad

Giant cell tumor (GCT) of tendon sheath is a localized form of tenosynovial GCT, which preferentially affects the joints of hands and feet. Chondroid metaplasia is a rare phenomenon in tenosynovial GCT either in localized or diffuse types. The current case investigates the cytological and histopathological features of chondroid GCT of tendon sheath in a 22-year-old female presenting with wrist swelling.

Tendon sheath

10.4081/rt.2015.5814

Cite

Citations (6)

Lymphoepithelioma‐like carcinoma of the breast: Cytological, histological, and immunohistochemical characteristics

Diagnostic Cytopathology (2014)

Asmaa Gaber Abdou Nancy Youssef Asaad

10.1002/dc.23141

Cite

Citations (9)

Sebaceous trichofolliculoma of the cheek in a 65-year-old man

Polish Journal of Pathology (2014)

Asmaa Gaber Abdou Nancy Youssef Asaad

Sebaceous trichofolliculoma is considered as hamartomatous lesion with follicular differentiation. In this study, we demonstrated a classic histopathologic picture of sebaceous trichofolliculoma in a 65-year-old male presented with large sized right cheek swelling.

Cheek

10.5114/pjp.2014.45792

Cite

Citations (2)

The Prognostic Role of Tumor-Associated Macrophages and Dendritic Cells in Classic Hodgkin's Lymphoma

Journal of Environmental Pathology Toxicology and Oncology (2013)

Asmaa Gaber Abdou Nancy Youssef Asaad Iman Loay Mohammed Shabaan Nahla Badr

Tumor-associated macrophages (TAMs) and dendritic cells (DCs) may play a role in tumor progression as a part of the tumor microenvironment in many neoplasms, including those in Hodgkin's lymphoma. The current study investigated the relationship between the presence and density of macrophages and dendritic cells in the background of classic Hodgkin's lymphoma (CHL) and different clinicopathological parameters, including survival and response to therapy. CD68 and CD1a immunohistochemical staining were used to detect and highlight macrophages and dendritic cells, respectively, in 61 cases of CHL. CD68 was expressed in all studied cases, with no significant association with the studied parameters. In total, 54.1% (33/61) of cases showed CD1a expression. High CD1a expression (>7%) was associated with localized lymphadenopathy (p=0.01), early stage (p=0.005), and good revised international prognostic index (R-IPI) (p=0.07). Hodgkin's lymphoma cases that showed high CD68 and low CD1a were associated with adverse prognostic parameters such as advanced stage (p=0.03) and generalized lymphadenopathy (p=0.05). Old age (>60 years) (P=0.005), poor R-IPI (P=0.010), and negative CD1a expression (P=0.045) were significantly associated with poor outcome. Finally, our study demonstrated the importance of the presence and density of DCs in determining progression and prognosis in CHL. A certain interaction between TAMs and DCs may affect the progression of CHL. Further investigation is required to clarify whether TAMs release certain factors that decrease the number or function of DCs.

CD68

Tumor progression

International Prognostic Index

10.1615/jenvironpatholtoxicoloncol.2013007930

Cite

Citations (13)

The Prognostic Value of Skp2 Expression in Egyptian Diffuse Large B-Cell Lymphoma

Applied immunohistochemistry & molecular morphology (2011)

Asmaa Gaber Abdou Nancy Youssef Asaad Moshira Mohammed Abd El-Wahed Rehab Monir Samaka Marwa Salah Gad Allah

Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoma worldwide. Both morphologically and prognostically, it represents a disease of a diverse spectrum. S-phase kinase-associated protein 2 (Skp2) is a member of mammalian F-box proteins, which displays S-phase-promoting function through ubiquitin-mediated proteolysis of the cyclin-dependent kinase inhibitor, p27. The aim of this study is to evaluate the prognostic value of Skp2 in DLBCL (70 cases) by immunohistochemical staining technique, and its correlation with the clinicopathological features and survival. Five (25%) control cases (reactive follicular hyperplasia) showed high Skp2 expression compared with 52.9% of DLBCL using 10% as a cutoff point with a significant difference (P=0.04). Skp2 was seen staining the large cells in proliferating germinal centers of the control group. High Skp2 expression in DLBCL was associated with several progressive parameters, such as advanced stage (P=0.036), involvement of more than one extranodal site (P=0.05), and high proliferation (P=0.0001). It was also significantly associated with the presence (P=0.007) and extent (P=0.002) of necrosis and inversely correlated with p27 expression (P=0.0001). From this study, Skp2 expression in DLBCL identified subset of cases characterized by aggressive features such as advanced stage, increased number of extranodal sites, high proliferation, and shorter survival time. The association of Skp2 with necrosis may be a reflection of its ability in promoting proliferative tumor capacity.

SKP2

10.1097/pai.0b013e318219a19f

Cite

Citations (8)

Significance of RCC2, Rac1 and p53 Expression in Breast Infiltrating Ductal Carcinoma; An Immunohistochemical Study

Iranian journal of pathology (2024)

Aiat Shaban Hemida Reham Abdelaziz Moshira Mohammed Abd El-Wahed Nancy Youssef Asaad Marwa Mohammed Serag El-Edien

The regulator of chromosome condensation 2 (RCC2) and RAS-related C3 botulinum toxin substrate 1 (Rac1) have been implicated in the promotion of breast cancer cell proliferation and migration. The signaling pathway involving p53/RCC2/Rac1 has been proposed to contribute to the regulation of colon cancer metastasis. However, until now, this pathway has not been thoroughly investigated in breast cancer. This study seeks to explore the influence of immunohistochemical expression and the correlation among RCC2, Rac1, and p53 in breast infiltrating ductal carcinoma (IDC).

Lymphovascular invasion

Breast carcinoma

Immunostaining

10.30699/ijp.2024.2014367.3198

Cite

Citations (1)