David J. Brunswick

University of Pennsylvania

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Jay D. Amsterdam

University of Pennsylvania

Alan Frazer

Roswell Park Comprehensive Cancer Center

J. Mendels

Thomas Jefferson University

Shanaz M. Tejani‐Butt

University of the Sciences

Barry S. Cooperman

University of Pennsylvania

L. Potter

Cardiff University

Paul Conway

Trinity College Dublin

Carl E. Aronson

University of Pennsylvania

Saloua Benmansour

Cheikh Anta Diop University

John P. O’Reardon

Temple University

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University of Pennsylvania

United States Department of Veterans Affairs

Philadelphia University

Harvard University

Hospital of the University of Pennsylvania

Massachusetts General Hospital

National Institute of Mental Health

Cornell University

New York State Psychiatric Institute

The University of Texas Health Science Center at San Antonio

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Radioimmunoassay of imipramine and desmethylimipramine

Life Sciences (1978)

David J. Brunswick Barbara Needelman J. Mendels

Desipramine

Bovine serum albumin

Conjugate

10.1016/0024-3205(78)90530-1

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Citations (36)

Photoincorporation of puromycin and N-(ethyl-2-diazomalonyl)puromycin into Escherichia coli ribosomes.

Proceedings of the National Academy of Sciences (1975)

Barry S. Cooperman E. N. Jaynes David J. Brunswick M.A. Luddy

[3H]Puromycin and N-(ethyl-2-diazomalonyl)[3H]puromycin are incorporated into E. coli ribosomes on irradiation at 253.7 nm. Both compounds incorporate into both protein and nucleic acid. Two-dimensional gel electrophoresis of ribosomal protein shows that L23 is the major protein labeled by puromycin. Although incorporation is clearly a complex process, evidence is presented that L23 is labeled via an affinity labeling process, thus placing L23 at the aminoacyl-tRNA receptor (A) site. N-(ethyl-2-diazomalonyl)puromycin is a ribosomal ligand, as shown by its inhibition of two ribosomal assays, but it is not a good puromycin analog, and it is unclear whether its incorporation, which proceeds via both carbene-dependent and carbene-independent processes, results from affinity labeling.

Puromycin

Ribosomal protein

10.1073/pnas.72.8.2974

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Citations (44)

Relevancy of tricyclic antidepressant plasma levels

American Journal of Psychiatry (1981)

D. Nutter David J. Brunswick

Tricyclic

Tricyclic antidepressant

Plasma levels

10.1176/ajp.138.4.526

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Citations (3)

[3H]Nisoxetine: a new radioligand for norepinephrine uptake sites in brain

European Journal of Pharmacology (1990)

Shanaz M. Tejani‐Butt David J. Brunswick Alan Frazer

Radioligand

Radioligand Assay

Neurotoxin

10.1016/0014-2999(90)94155-q

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Citations (98)

Isomerism of disubstituted tricycloquinazolines

Chemical Communications (London) (1967)

David J. Brunswick M. W. Partridge H. J. Vipond

D. J. Brunswick, M. W. Partridge and H. J. Vipond, Chem. Commun. (London), 1967, 884 DOI: 10.1039/C19670000884

10.1039/c19670000884

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Citations (1)

Desmethylimipramine-induced decrease in β-adrenergic receptor binding in rat cerebral cortex

Biochemical Pharmacology (1978)

Keisuke Sarai Alan Frazer David J. Brunswick J. Mendels

Desipramine

10.1016/0006-2952(78)90293-9

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Citations (141)

Antidepressant monotherapy for bipolar type II major depression

Bipolar Disorders (2003)

Jay D. Amsterdam David J. Brunswick

Objectives: Bipolar type II (BP II) disorder is thought to be distinct from BP I disorder on genetic and biological grounds, and it is not merely a milder form of the illness. It affects 1.5–2.5% of the US adult population, and is characterized by highly recurrent depressive episodes with a substantial morbidity from alcoholism and non‐affective psychopathology, and a higher suicide rate than either BP I or unipolar depression. Treatment recommendations for BP II depression are based upon concerns over drug‐induced manic‐switch episodes, and suggest using either a mood stabilizer alone or a combination of an SSRI plus a mood stabilizer. Recent evidence, however, indicates that the rate of manic switch episodes may be modest in BP II patients. Recent studies have provided evidence that antidepressant monotherapy may be an effective initial and long‐term treatment for BP II major depression with a low manic‐switch rate. Methods: In this article, we review the recent literature on BP II disorder, with a focus on the treatment of BP II major depression. Results: We present a summary of data from recent studies by our group and others indicating that antidepressant monotherapy for BP II depression may be safe and effective with a low manic‐switch rate. Conclusion: Antidepressant monotherapy may be beneficial for some patients with BP II major depression.

Depression

Mood stabilizer

Major depressive episode

Endogenous depression

Bipolar II disorder

10.1046/j.1399-5618.2003.00066.x

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Citations (56)

Red Blood Cell Li<sup>+</sup> to Plasma Li<sup>+</sup> Ratios

Neuropsychobiology (1978)

David J. Brunswick Alan Frazer J. Mendels Alan B. Ramsey

The relationship between the lithium ratio (ratio of lithium in blood cells to that in plasma) and plasma lithium concentration was examined in a group of male inpatients taking lithium carbonate for affective disorders. The lithium ratio was found to increase in the majority of these patients as plasma lithium concentration increased. However, the magnitude of variation of the lithium ratio with plasma lithium concentration observed in these patients is not sufficient to seriously affect the value of determining the lithium ratio in the clinical situation.

Lithium carbonate

10.1159/000117626

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Citations (11)

Synthesis and characterization of photoaffinity labels for adenosine cyclic 3',5'-monophosphate and adenosine 5'-monophosphate

Biochemistry (1973)

David J. Brunswick Barry S. Cooperman

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and characterization of photoaffinity labels for adenosine cyclic 3',5'-monophosphate and adenosine 5'-monophosphateDavid J. Brunswick and Barry S. CoopermanCite this: Biochemistry 1973, 12, 21, 4074–4078Publication Date (Print):October 1, 1973Publication History Published online1 May 2002Published inissue 1 October 1973https://pubs.acs.org/doi/10.1021/bi00745a008https://doi.org/10.1021/bi00745a008research-articleACS PublicationsRequest reuse permissionsArticle Views60Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts

Cyclic adenosine monophosphate

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Photoaffinity labeling

Adenosine monophosphate

10.1021/bi00745a008

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Citations (29)

A comment on E. Servadio's A presumptive telepathic precognitive dream during analysis.

PubMed (1957)

David J. Brunswick

Telepathy

Source

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Citations (3)