Heba M. Mashaly

Cairo University

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Olfat Shaker

Cairo University

Medhat El‐Mofty

Cairo University

Wedad Z. Mostafa

Tanta University

Samia Esmat

Cairo University

Randa Youssef

Cairo University

Mohamed H.M. El-Komy

Cairo University

Manal Bosseila

Cairo University

Doaa Mahgoub

Cairo University

Noha Nagui

Cairo University

Khadiga S. Sayed

Cairo University

Cooperative Institutions

Cairo University

National Research Centre

University Dermatology

National Water Research Center

Ain Shams University

Advanced Dermatology

Institute of Dermatology

Fayoum University

Tanta University

Cairo University hospitals

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Protocol of Kasr Al-Ainy’s phototherapy unit − Cairo University for the management of photoresponsive skin diseases − part 1

Journal of the Egyptian Womenʼs Dermatologic Society (2022)

Medhat El‐Mofty Wedad Z. Mostafa Samia Esmat Randa M. Youssef Manal Bosseila

One of the most commonly used and effective lines of treatment in chronic skin diseases is phototherapy. A protocol of the Kasr Al-Ainy Phototherapy Unit has been proposed for the treatment of different dermatological diseases such as psoriasis, mycosis fungoides, and vitiligo based on the best current research-based guidelines and the experience of the phototherapy team. This protocol is the cornerstone of the everyday practice in Kasr Al-Ainy Phototherapy Unit and we believe dermatologists dealing with such diseases in their hospitals or clinics, can find it helpful and applicable to get better results with their patients. In part 1, the general measures of the protocol will be discussed.

10.4103/jewd.jewd_58_21

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Citations (2)

A large scale analytical study on efficacy of different photo(chemo)therapeutic modalities in the treatment of psoriasis, vitiligo and mycosis fungoides

Dermatologic Therapy (2010)

Medhat El‐Mofty Wedad Z. Mostafa Manal Bosseila Randa Youssef Samia Esmat

Psoriasis, vitiligo, and mycosis fungoides (MF) are among the most frequently treated dermatological diseases by photo(chemo)therapy. The objectives are to determine which photo (chemo) therapeutic modality could achieve the best response in the treatment of psoriasis, vitiligo, and MF. The design used in this study is retrospective analytical study. The study included 745 patients' records; 293 with psoriasis, 309 with vitiligo, and 143 with early MF, treated in the Phototherapy Unit, Dermatology Department, Kasr El-Aini Hospital, Cairo University by either psoralen and ultraviolet A (PUVA), narrow band ultraviolet B (NB-UVB), psoralen and narrow band UVB (P-NBUVB), broad band UVB (BB-UVB), or broad band UVA (ΒΒ-UVA). Data were retrieved from the computer database of the unit and statistically analyzed. In psoriasis, oral and topical PUVA and NB-UVB were found to be equally effective, whereas oral PUVA had significantly better results than both UVA and BB-UVB at the end of therapy. In generalized vitiligo, PUVA and P-NBUVB had significantly better results than NB-UVB alone. In early MF, there was no statistically significant difference between the response to oral PUVA and NB-UVB. PUVA and NB-UVB are good choices in patients with psoriasis and early stage MF, whereas PUVA appears the best choice in the treatment of vitiligo.

Vitiligo

PUVA therapy

Ultraviolet b

Ultraviolet therapy

10.1111/j.1529-8019.2010.01345.x

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Citations (33)

Evaluation of carcinogenic risk of PUVA versus Re-PUVA in psoriatic patients

Journal of the Egyptian Womenʼs Dermatologic Society (2017)

Heba M. Mashaly Marwa F. Hussein Shaimaa Hamdy Olfat Shaker

PUVA therapy

10.1097/01.ewx.0000499599.92590.a4

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Citations (0)

Comparison between serum level of superoxide dismutase, malondialdehyde, and DNA damage in acne vulgaris and vitiligo patients

Journal of the Egyptian Womenʼs Dermatologic Society (2016)

Heba H. El Hadidia Heba M. Mashaly Gamila S. Mohamed Hanaa Emam Shaimaa El Fawy

Vitiligo

Malondialdehyde

10.1097/01.ewx.0000482792.76474.f3

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Citations (2)

Classification of Papulo‐Squamous skin diseases using image analysis

Skin Research and Technology (2011)

Heba M. Mashaly Naveen Masood Abdalla Mohamed

Introduction: Papulo‐squamous skin diseases are variable but are very close in their clinical features. They present with the same lesions, erythematous scaly lesions. Clinical evaluation of skin lesions is based on common sense and experience of the dermatologist to differentiate features of each disease. Aim: To evaluate a computer‐based image analysis system as a helping tool for classification of commonly encountered diseases. Materials and Methods: The study included 50 selected images from each of psoriasis, lichen planus, atopic dermatitis, seborrheic dermatitis, pityrasis rosea, and pitryasis rubra pilaris with a total of 300 images. The study comprised three main processes peformed on the 300 included images: segmentation, feature extraction followed by classification. Results: Rough sets recorded the highest percentage of accuracy and sensitivity of segmentation for the six groups of diseases compared with the other three used techniques (topological derivative, K‐means clustering, and watershed). Rule‐based classifier using the concept of rough sets recorded the best percentage of classification (96.7%) for the six groups of diseases compared with the other six techniques of classification used: K‐means clustering, fuzzy c‐means clustering, classification and regression tree, rule‐based classifier with discretization, and K‐nearest neighbor technique. Conclusion: Rough sets approach proves its superiority for both the segmentation and the classification processes of papulo‐squamous skin diseases compared with the other used segmentation and classification techniques.

10.1111/j.1600-0846.2011.00511.x

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Citations (8)

The role of systemic steroids and phototherapy in the treatment of stable vitiligo: a randomized controlled trial

Dermatologic Therapy (2016)

Medhat El Mofty Samia Essmat Randa Youssef Sherine Sobeih Doaa Mahgoub

Pathogenesis of vitiligo is believed to be multifactorial disease with a wide variety of therapeutic modalities. The aim of this work is to assess the efficacy of oral mini-pulse steroids (OMP) plus Nb-U.V.B in comparison to OMP alone and Nb-U.V.B alone in treating stable vitiligo. A prospective randomized controlled study including 45 patients categorized into three groups receiving therapy for 3 months; Group A received Nb-U.V.B plus OMP, Group B received OMP alone while Group C received Nb-U.V.B alone. Clinical assessment and PCR evaluation of bFGF, ICAM1, and ELISA for AMA were done. Patients receiving Nb-U.V.B plus OMP and using Nb-U.V.B alone gave statistically significant clinical response than those treated with OMP alone. Statistically significant rise of BFGF was noticed after treatment with Nb-U.V.B plus OMP and with Nb-U.V.B alone. Patients treated with OMP alone and with Nb-U.V.B alone showed statistically significant drop of ICAM-1 after therapy. NB-U.V.B plus OMP and Nb-U.V.B alone were found to be clinically superior over OMP alone in treating stable vitiligo patients, hence suggesting that adding OMP to Nb-U.V.B can maintain clinical and laboratory success for a longer period of time and with less relapse.

Vitiligo

Group B

10.1111/dth.12384

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Citations (29)

Broadband ultraviolet A vs. psoralen ultraviolet A in the treatment of vitiligo: a randomized controlled trial

Clinical and Experimental Dermatology (2013)

Medhat El Mofty Manal Bosseila Heba M. Mashaly Heba I. Gawdat H. Makaly

Psoralen ultraviolet A (PUVA) and narrowband (NB)-UVB have been shown to be efficacious in the treatment of vitiligo. With large and repeated doses, UVA may lead to immediate skin darkening and to delayed tanning. Our previous experience with broadband (BB)-UVA in vitiligo showed encouraging results.To test the efficacy of BB-UVA in vitiligo and to evaluate if it could provide an alternative treatment for this condition.This prospective, randomized, controlled, comparative clinical trial enrolled 45 patients with vitiligo, who were randomly divided into three groups, with group A receiving UVA 15 J/cm(2) /session, group B receiving UVA 10 J/cm(2) /session, and group C receiving PUVA. The patients received three sessions/week for 5 months, with 60 sessions in total.At the mid-point of treatment, clinical response was significantly higher in patients receiving PUVA than in the other two groups At the end of the study, clinical response was comparable for groups A and C (UVA 15 J/cm(2) and PUVA, respectively), and both were significantly higher than the group receiving UVA 10 J/cm(2) . Patients in the PUVA group responded mainly with perifollicular pigmentation, whereas those receiving UVA responded mainly with lesional tanning.BB-UVA at a dose of 15 J/cm(2) /session gives results for vitiligo that are comparable to PUVA, suggesting it might be useful when oral psoralens are contraindicated.

Vitiligo

PUVA therapy

Ultraviolet b

Ultraviolet a

Methoxsalen

10.1111/ced.12099

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Citations (15)

Clinical and epidemiologic features of psoriasis patients in an Egyptian medical center

JAAD International (2020)

Mohamed H.M. El-Komy Heba M. Mashaly Khadiga S. Sayed Vanessa Hafez Marwa S. El‐Mesidy

Identification of epidemiologic and phenotypic variations of psoriasis among different ethnic groups can further our understanding of this perplexing disease, aiming at better management of patients worldwide.To provide a descriptive analysis of psoriasis patients registered at Kasr Al-Ainy Psoriasis Unit Disease Registry.This retrospective single-center registry study included patient records between November 2015 and November 2018 (2534 patients). Sociodemographic and phenotypic data were analyzed.The mean age of the registered patients was 39.3 years and 56.3% were men. Stress was the main precipitating factor (48.3%), whereas the most common symptom reported was itching (82.4%). The median body mass index was 27.5, and the median percentage of body surface area involved was 10.0. The mean Psoriasis Area Severity Index score was 8.7, and the mean Psoriasis Disability Index score was 13.0. Both parameters correlated positively, and both showed significantly higher means in smokers.Despite that the study was performed at a highly specialized tertiary care center with a high flow of patients, this was still a single-center registry.This work shows that the characteristics of Egyptian patients with psoriasis are comparable to those of other studied ethnic groups, with minor differences.

Medical record

10.1016/j.jdin.2020.06.002

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Citations (35)

Lipedema and lipedematous alopecia: report of 10 new cases.

PubMed (2007)

Mohammad A. El Darouti Salonas A. Marzouk Heba M. Mashaly Eman A. El Nabarawi Mohamed H.M. El-Komy

10.1684/ejd.2007.0226

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Citations (15)

Topical calcineurin inhibitors in atopic dermatitis: A systematic review and meta-analysis

Journal of Dermatological Science (2009)