Louis D. Lowry

Thomas Jefferson University

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Co-Authors

I. M. Young

Thomas Jefferson University

William M. Keane

Thomas Jefferson University

Diego Restrepo

University of Colorado Anschutz Medical Campus

Chester R. Wilpizeski

Thomas Jefferson University

Beverly J. Cowart

Monell Chemical Senses Center

Nancy E. Rawson

Monell Chemical Senses Center

Vijay M. Rao

University Hospitals of North Midlands NHS Trust

James B. Snow

The University of Texas at Austin

Edmund A. Pribitkin

Thomas Jefferson University

Simon Krämer

ETH Zurich

Cooperative Institutions

Thomas Jefferson University

Philadelphia University

Thomas Jefferson University Hospital

University of Pennsylvania

Jefferson College

Hospital of the University of Pennsylvania

Children's Hospital of Philadelphia

Johns Hopkins University

Monell Chemical Senses Center

Jefferson University Hospitals

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Alterations in bilateral tinnitus following an exposure to a pure tone

The Journal of the Acoustical Society of America (1982)

I. M. Young Louis D. Lowry

In a subject with bilateral tinnitus of a pitch 10 000 Hz, loudness 50–55 dB SPL, left ear was exposed to a steady tone, 500 Hz, at 121 dB SPL for 21 min. Immediately following cessation of stimulation, tinnitus had completely disappeared from stimulated ear and was heard in the opposite nonstimulated right ear. Three hours after stimulation, tinnitus was heard in the left ear as mixture of multiple frequencies superimposed upon broadband noise and/or low-pass filtered noise. Twenty-four hours after stimulation, tinnitus pitch changed to 3260 Hz, 2 days later 5100 Hz, 3 days later 8310 Hz, and 1 week later returned to original pitch 10 000 Hz and stayed on to date. In the nonstimulated right ear, however, immediately after cessation of stimulation, tinnitus pitch was 6700–8000 Hz for 48 h. Thereafter, tinnitus has been fluctuating from 8000–9000 Hz to a narrow-band noise centered around 7986 Hz with a bandwidth of 2710 Hz and vice versa. The tinnitus never returned to previous pre-exposure pitch of 10 000 until 4 weeks after exposure. There was an apparent difference of recovery process between two ears. Factors influencing tinnitus in two ears were discussed.

Pure tone

Tone (literature)

10.1121/1.2019190

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Standardization of Computer Systems for Logging Operative Cases

Archives of Otolaryngology - Head and Neck Surgery (1988)

Martin Feldman Louis D. Lowry H. Jay Wisnicki

With the advent of extremely rapid, powerful, compact, and inexpensive microcomputers, a revolution in data manipulation is ongoing. We have customized and used for over two years prepackaged software to track residents' operative experiences in the Department of Otolaryngology at Jefferson Medical College of Thomas Jefferson University, Philadelphia. An attempt is presently being made to develop a similar system that might be utilized by all otolaryngology teaching programs and thus enable the collection and review of residents' operative experiences nationally. A basic, relational database system is proposed for entering resident caseload data and generating reports for periodic review.

10.1001/archotol.1988.01860220112035

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Citations (4)

Vagal Paraganglioma: Evaluation and Treatment

Otolaryngology (1997)

Randy B. Miller Louis D. Lowry John F. Atkins William M. Keane

Miller

10.1016/s0194-59989780422-6

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Otolaryngic findings in the cleft palate population

Plastic & Reconstructive Surgery (1975)

Louis D. Lowry Bobert Billings Jane Leonard

International Abrtracts of Plastic and Reconstructive Surgery: Congenital Anomalies: Cleft Lip and Palate: PDF Only

Reconstructive Surgery

10.1097/00006534-197502000-00066

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Citations (1)

Loudness recruitment in abrupt drop sensorineural hearing impairment.

PubMed (1982)

I M Young Louis D. Lowry

Monaural bifrequency loudness balance tests were performed on 11 adults with abrupt drop sensorineural hearing impairment. To study frequencies on the slope, 2-octave Bekesy threshold measurements were made beginning at a frequency exhibiting normal hearing nearest to initiation of the slope (F1). Loudness was matched (Test 1) between F1 and F2 (a frequency nearest to termination of the slope), (Test 2) between F1 and F1 + F2/2 (a frequency halfway between F1 and F2), and (Test 3) between F1 and 2F1 (a frequency an octave above F1). Our data indicated that a combination of asymptotic and straight-line recruitment was demonstrated in Test 1, pure asymptotic recruitment in Test 2, and straight-line recruitment in Test 3. It was speculated that diffuse hair cell lesions such as in frequency areas in the vicinity of 2F1 in abrupt drop sensorineural hearing impairment or endolymphatic hydrops may show straight-line recruitment, and discrete outer hair cell lesions such as frequency regions around F1 + F2/2 may demonstrate pure asymptotic recruitment. Our results were discussed in relation to histopathological findings of human and animal subjects with abrupt drop hearing loss reported by other investigators. Data appeared to show a relationship between the types of loudness recruitment and the hair cell damage.

Endolymphatic hydrops

Monaural

Otoacoustic emission

Audiogram

Source

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Vagal paraganglioma: The Jefferson experience

Otolaryngology (2000)

Randy B. Miller Maurits Boon John F. Atkins Louis D. Lowry

Vagal paraganglioma is a rare tumor of neural crest origin. Although the literature is in agreement with regard to epidemiology, diagnosis, and tumor biology, there is some controversy over treatment modalities for these patients. We performed a nonrandomized retrospective study in a large single-institution series of patients (n = 19) in whom vagal paraganglioma was diagnosed. General statistics included age, male/female ratio, tumor size, and duration of follow-up. Other variables such as signs and symptoms at presentation, family history, multicentricity, metastatic disease, and secretion of catecholamines were included. CT scan, MRI, and angiography were used in combination for diagnostic purposes as well as for treatment planning. Preoperative embolization was performed in 5 of the more recently treated patients. Current issues regarding the use of preoperative embolization and choice of surgical approach were analyzed. In this article the possibility and sequela of vagus nerve-sparing procedures will be presented. Operative complications and postoperative morbidity related to cranial neuropathies will be discussed. The rationale for performing adjunct procedures, including cricopharyngeal myotomy and vocal fold medialization, to facilitate the rehabilitation of patients with postoperative cranial nerve deficits will be given. Our findings and recommendations will be compared with currently accepted treatment protocols in conjunction with a review of the literature.

Chemodectoma

Sequela

Presentation (obstetrics)

10.1067/mhn.2000.102807

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Citations (64)

Artificial larynges: A review and development of a prototype self‐contained intra‐oral artificial larynx

The Laryngoscope (1981)

Louis D. Lowry

Abstract New means of speaking after laryngectomy or loss of continuity of the airway have consisted of: 1. Pharyngostome with artificial larynx (artificial mechanism connecting the trachea to the pharynx). 2. Artificial sound to nose or mouth (e.g., bellows, grammaphone). 3. A reed device from tracheostome to the mouth or the nose. 4. Tracheoesophageal fistula with or without a communicating connecting device. 5. Transcervical sound source which is used by placing a sound source on the external neck transmitting the sound into the pharynx. 6. The implanted sound source, or 7. Intra‐oral sound source. This paper will review devices used to aid in artificial speech production provided in the past. No attempt will be made at reviewing the surgical literature on voice conservation procedures. Four sections are presented: 1. Early History of Laryngectomy and Review of Historical Artificial Larynges, 2. History of Alaryngeal Speech Production Without an Artificial Device, 3. Studies of Speech Production, Comparisons of Esophageal and Artificial Laryngeal Speech, and 4. Development of the Prototype Self‐Contained Intra‐Oral Artificial Larynx; synopsis of references reviewed in the first three sections; and a presentation of our new device in the fourth section. Each review is presented in chronological order with dates provided. Each of the first three sections is independent but relates to the common problem of alaryngeal speech. At the onset of design the self‐contained intra‐oral artificial larynx was thought to be only for persons after laryngectomy who for some reason could not attain esophageal speech. Later it became apparent that there are others, such as quadriplegics with tra‐cheostomies, who could also benefit from an artificial larynx which is orally controlled. The artificial larynx being tested at present in our lab is fitted into a dental plate or dental shim with a hearing aid speaker and a built‐in exponential horn which opens posteriorly. This artificial larynx is in its third revision and, at present, is externally wired during the testing phases. In its final form the power supply, electronic circuits, off‐on switch, speaker and exponential horn will be completely contained in the dental prosthesis. Modifications are being made to obtain appropriate loudness with a decreased voltage requiring fewer batteries fitted into the prosthesis. The circuits will be placed on a microcomputer chip after the best circuits have been obtained by testing externally placed hard wired circuits on several objects.

Esophageal speech

10.1288/00005537-198108000-00016

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Citations (29)

Effect of Chlorine Bleach on the Esophagus

Annals of Otology Rhinology & Laryngology (1974)

Carl T. Hook Louis D. Lowry

The stimulus for this review and study was the report of experimentally produced esophageal burns in animals secondary to Clorox® ingestion which was reported by previous investigators in Chicago. Twenty-six children have been admitted to Children's Memorial Hospital since 1969 with “bleach ingestion” as the diagnosis. All but six underwent esophagoscopy in compliance with a “Pediatrics-Otorhinolaryngology Study Protocol” in an attempt to diagnose esophageal burns. Chemical burn of the esophagus was found in only one case; however, the exact content of ingested material was not definitely identified. In the one case of chemical burn, treatment was performed per protocol, and the patient is free of symptoms of stricture eighteen months postingestion. None of the other twenty-five patients have returned for treatment of ingestion sequelae. A laboratory study was conducted which utilized cats to simulate Clorox® ingestion by children. The cats were sacrificed at varying periods of time following ingestion with gross and microscopic exam of each esophagus being performed. Results showed the potential of chlorine bleach to cause chemical burns and superficial ulceration, but no stricture or residual sequelae when ingested in a manner simulating physiologic swallowing. Appropriate conclusions were made in respect to treatment of future patients with the diagnosis of “bleach ingestion.”

Bleach

Chemical burn

Esophageal stricture

10.1177/000348947408300601

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Citations (6)

Head and neck cancer

American Journal of Otolaryngology (1994)

Louis D. Lowry

10.1016/0196-0709(94)90076-0

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