M. G. Sarngadharan

Research Field

Lymphoblast

Terminal deoxynucleotidyl transferase

Cell fractionation

10.1016/b978-0-08-024417-4.50019-6

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Citations (1)

Serological detection of antibodies to HTLV-III in sera of patients with aids and pre-AIDS conditions

International Journal of Radiation Applications and Instrumentation Part B Nuclear Medicine and Biology (1986)

Robert C. Gallo Mikuláš Popovič M. G. Sarngadharan

10.1016/0883-2897(86)90118-2

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Long-term inhibition of human T-ly: lymphadenopathy-associated virus ( virus) DNA synthesis and RNA exp protected by 2',3'-dideoxynucleosid

Hiroaki Mitsuya Ruth F. JARRETTt Makoto Mats Anthony L. DeVico M. G. Sarngadharan

We report that 2',3'-dideoxyadenosine and 2',3'-dideoxycytidine inhibit retroviral DNA synthesis and mRNA expression in T cells exposed to the virus that causes acquired immunodeficiency syndrome, and afford such cells long-term protection in vitro under conditions of substantial viral excess. Both 2',3'-dideoxyadenosine and 2'3'-dideoxy- cytidine appear to completely block reverse transcription from viral RNA to viral DNA. Viral mRNA expression is also not detected in cells protected by the drugs throughout 30 days of culture following exposure to the virus. Purine and pyrimidine analogues as 2',3'-dideoxynucleoside-5'.triphosphate serve as substrates for the human T-lymphotropic virus type IH/- lymphadenopathy-associated virus reverse transcriptase to elongate a DNA chain by one residue, after which the chain is terminated. Cloned normal helper/inducer T cells exposed to a cytopathic dose of the virus, but protected by the drugs, respond normally to specific antigen in vitro. These results suggest that the drugs could be promising agents for further studies in the expetimental treatment of patients infected with retroviruses.

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Application of NASBA Technology in the Study of Retroviral Infection in vitro and in vivo

Joseph Romano Roxanne N. Shurtliff R Pal M. G. Sarngadharan M. Kaplan

NASBA

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Human immunodeficiency virus type 1 capsid protein is a substrate of the retroviral proteinase while integrase is resistant toward proteolysis

Virology (2003)

József Tőzsér Sergey Shulenin János Kádas Péter Boross Péter Bagossi

Proteolysis

Cleavage (geology)

Group-specific antigen

Oligopeptide

10.1016/s0042-6822(03)00074-6

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Citations (13)

Unexplained Persistent Lymphadenopathy in Homosexual Men and the Acquired Immune Deficiency Syndrome

Medicine (1985)

Jonathan W.M. Gold C S Weikel James Godbold Carlos F. Garcia Carlos Urmacher

GOLD, JONATHAN W. M. M.D.1; WEIKEL, CYNTHIA S. M.D.1; GODBOLD, JAMES PH.D.2; GARCIA, CARLOS M.D.3; URMACHER, CARLOS M.D.3; CUNNINGHAM-RUNDLES, SUSANNA PH.D.4; KOZINER, BENJAMIN M.D.4; POLLACK, MARILYN PH.D.4; GALLO, ROBERT C. M.D.5; SARNGADHARAN, M. G. PH.D.6; ARMSTRONG, DONALD M.D.1 Author Information

Leukopenia

Generalized lymphadenopathy

Cervical lymphadenopathy

AIDS-related complex

10.1097/00005792-198505000-00005

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Citations (36)

Processing of the Envelope and Core Proteins of Human Immunodeficiency Virus Type 1

De Gruyter eBooks (1989)

M. G. Sarngadharan Ranajit Pal

Envelope (radar)

Core protein

10.1515/9783110862782-005

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Citations (0)

Conformational Perturbation of the Envelope Glycoprotein gp120 of Human Immunodeficiency Virus Type 1 by Soluble CD4 and the Lectin Succinyl Con A

Virology (1993)

Ranajit Pal Anthony L. DeVico Stephen Rittenhouse M. G. Sarngadharan

V3 loop

Syncytium

C-type lectin

10.1006/viro.1993.1326

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Citations (9)

Immunological properties of HTLV-III antigens recognized by sera of patients with AIDS and AIDS-related complex and of asymptomatic carriers of HTLV-III infection.

PubMed (1985)

M. G. Sarngadharan Fulvia DiMarzo Veronese Stephanie J. Lee Robert C. Gallo

A high correlation was found among antibodies to human T-cell leukemia virus type III (HTLV-III), acquired immunodeficiency syndrome, and acquired immunodeficiency syndrome-related complex. With the Western blot technique the antigens (shown as proteins with molecular weights given in thousands) in HTLV-III lysates recognized by positive sera have been identified as p120, p66, p51, p41, p31, p24, and p17. The most common reactivity was toward p41. Lectin fractionation identified p120 and p41 as glycoproteins. Studies using mouse monoclonal antibodies to the p24 proteins of HTLV-I, -II, and -III showed that HTLV-I and -II have common epitopes in p24 molecule, but these are not the cross-reactive epitopes present on HTLV-III p24.

Polyclonal antibodies

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Citations (22)

Analysis of the interaction between Rauscher murine leukemia virus and murine cell membrane receptor by in vitro binding assay

Cancer Letters (1983)

Karabi Ganguly V. S. Kalyanaraman M. G. Sarngadharan

Cell membrane

Cell surface receptor

10.1016/0304-3835(83)90120-9

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Citations (7)