C. Forni

Institut de Biologie du Développement Marseille

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A. Nieoullon

Aix-Marseille Université

Nicole Dusticier

Institut de Biologie du Développement Marseille

J. C. Rostain

Aix-Marseille Université

Pascal Salin

Institut de Biologie du Développement Marseille

A. Daszuta

Centre National de la Recherche Scientifique

Anders Björklund

Lund University

Aı̈cha Aouane

Institut de Biologie du Développement Marseille

O. Mainard

Institut Supérieur de l'Électronique et du Numérique

Edith Kussener

Institut des Matériaux, de Microélectronique et des Nanosciences de Provence

Alain Strambi

Centre National de la Recherche Scientifique

Cooperative Institutions

Centre National de la Recherche Scientifique

Institut de Biologie du Développement Marseille

Aix-Marseille Université

Institut de Neurophysiopathologie

Laboratoire de Neurobiologie Cellulaire et Moléculaire

Inserm

Institut Supérieur de l'Électronique et du Numérique

Laboratoire de Neurosciences Cognitives

Lund University

Centre d’Immunologie de Marseille-Luminy

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Characterization of striatal lesions produced by glutamate uptake alteration: Cell death, reactive gliosis, and changes in GLT1 and GADD45 mRNA expression

Glia (2000)

Jean-Charles Liévens Fabián Bernal C. Forni Nicole Mahy Lydia Kerkerian‐Le Goff

This study investigated the time course of the striatal lesions produced by continuous local injection of the glutamate uptake inhibitor, L-trans-pyrrolidine-2,4-dicarboxylate (PDC) at the rate of 25 nmol/h in rats. The extent of the neurodegeneration area (defined as the lesion area) did not significantly vary with the duration of the PDC treatment between 3 and 14 days, but was markedly reduced 3 months after cessation of the 14-day treatment, probably reflecting striatal atrophy. After the 3-day treatment, the lesion zone showed calcium precipitates and marked microglial reaction contrasting with the reduction of astroglial labeling and loss of the glutamate transporter GLT1 mRNA expression; however reactive astrocytes were observed around the lesion. After the 14-day treatment, the lesion zone presented reactive astrocytes and microglia without calcification, and a partial recovery of GLT1 mRNA expression. Interestingly, the growth arrest DNA damage-inducible GADD45 mRNA expression was induced around the lesion after 3 days but inside the lesion after 14 days of treatment. Three months after the 14-day treatment, the astroglial reactivity persisted within the lesion whereas most of the other markers examined tended to normalize. These data suggest that defective glutamate transport induces primary death of neurons and dysfunction of astrocytes. They strongly implicate reactive astrocytes with GLT1 and GADD45 transcripts in preventing secondary neuronal death.

Gliosis

Glial scar

10.1002/(sici)1098-1136(20000201)29:3<222::aid-glia4>3.0.co;2-0

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Citations (75)

Gamma-aminobutyric acid and the high pressure neurological syndrome

Neuropharmacology (1986)

J. C. Rostain Bridget Wardley‐Smith C. Forni Michael J. Halsey

Nipecotic acid

10.1016/0028-3908(86)90182-6

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Citations (35)

Intracerebral Grafting of Dopamine Neurons

Annals of the New York Academy of Sciences (1987)

Patrik Brundin Robert E. Strecker Olle Lindvall Ole Isacson Ola Nilsson

Histology

10.1111/j.1749-6632.1987.tb23695.x

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Citations (72)

[Dopaminergic regulation of the activity of peptidergic, GABAergic and glutamatergic neuronal systems in the striatum].

PubMed (1989)

Lydia Kerkerian‐Le Goff A. Cupo Nicole Dusticier Jacques Epelbaum M. Errami

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Citations (1)

Time-course of recovery of dopamine neuron activity during reinnervation of the denervated striatum by fetal mesencephalic grafts as assessed by in vivo voltammetry

Experimental Brain Research (1989)

C. Forni Patrik Brundin Robert E. Strecker Soumaya El Ganouni Anders Björklund

Reinnervation

Oxidopamine

Hydroxydopamine

10.1007/bf00253625

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Citations (39)

Implantable electrostimulation system in freely moving rodent for DBS treatment

IEEE Faible Tension Faible Consommation (2014)

Edith Kussener Juan Aguilar O. Mainard D. Goguenheim Ghislain Oudinet

A large number of solutions on electrostimulation were proposed in the last twenty years with the aim of looking after certain pathologies. They rely on the principle that electrostimulation of a neuron, muscle or another internal nerve is possible. In this context, this paper presents a solution of deep brain stimulator (DBS) having for aim to reduce the influence of the Parkinson's disease. This paper presents monophasic and biphasic electrostimulation topologies. The integrated system on chip solution was developped on 0.35¿m standard CMOS technology. The silicon die possesses a size of 620x550¿m2, with an improved battery life of about a week (ten times longer than the discrete version). The circuit has two terminals directly connected on the brain via two electrodes and two terminals to be connected to the coin cell battery (the only non under cutaneous part).

10.1109/ftfc.2014.6828596

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Citations (0)

[Effects of sulpiride isomers in the control of blood pressure in man].

PubMed (1980)

Fabio Benfenati Pietro Cortelli M. de Camillis Fabio Orlandi C. Forni

The effects of d-Sulpiride (25 mg i.v.) and 1-Sulpiride (25 mg i.v.) administration in the control of arterial blood pressure (ABP) and PRL-GH secretion have been analyzed in five normal male volunteers. It was observed a quite different action on ABP, 1-Sulpiride causing a long lasting hypotension and d-Sulpiride a short-lived hypertension. The correlation between ABP, heart rate and PRL-GH levels suggests a probable central cation for 1-Sulpiride and a possible peripheral action for d-Sulpiride effects on ABP.

Sulpiride

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Integrated continuous microstimulation system for deep brain stimulation in rodent models of neurological disorders

Edith Kussener T. Barroca B. Lincoln Pascal Salin C. Forni

This article proposes two prototypes in order to assure chronic deep brain stimulation in freely moving rodents, modeling the functional neurosurgical approach developed for the treatment of Parkinson's disease, which is now extending to a number of neurological and psychiatric diseases. This treatment is based on electrical simulation in a precise brain target with adapted parameters for each indication in terms of frequency, intensity and pulse width. The first topology, a discrete solution has been realized by using CMS technology and tested on a rat model of Parkinson's disease. The second one, even more miniaturized for a mouse application, is an all integrated solution with live tuning. A 0.35μm standard CMOS technology has been used for the realization of this last one solution with a final silicon ar ea of 620 * 516, 4μm ² .

Microstimulation

Realization (probability)

10.1109/newcas.2010.5603773

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Citations (5)

A role for nitric oxide in sensory-induced neurogenesis in an adult insect brain

HAL (Le Centre pour la Communication Scientifique Directe) (2005)

M. Cayre Jordane Malaterre Sophie Scotto‐Lomassese G. R. Holstein Gustavo Martinelli

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Citations (2)

Regulation of dopamine levels in intrastriatal grafts of fetal mesencephalic cell suspension: an in vivo voltammetric approach