A Yamaguchi

European Foundation for the Study of Chronic Liver Failure

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Yutaka Yonemura

Kishiwada Tokushukai Hospital

I Miyazaki

Kanazawa University

I Miyazaki

Kanazawa University

Sachio Fushida

Kishiwada Tokushukai Hospital

Takanori Goi

University of Fukui

Yutaka Yonemura

Kishiwada Tokushukai Hospital

K. Sugiyama

Hachinohe National College of Technology

G Nishimura

Japanese Red Cross Kanazawa Hospital

Kitao HACHISUKA

Higashi Nagoya National Hospital

Gizo Nakagawara

Municipal Tsuruga Hospital

Cooperative Institutions

European Foundation for the Study of Chronic Liver Failure

206

Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas

Kyoto University

Kanazawa University

The University of Tokyo

Universitat de Barcelona

Hospital Clínic de Barcelona

Consorci Institut D'Investigacions Biomediques August Pi I Sunyer

Nagoya University

University College London

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Chemohyperthermic peritoneal perfusion for peritoneal dissemination in various intra-abdominal malignancies.

PubMed (1999)

Takashi Fujimura Yutaka Yonemura Hideto Fujita Y Michiwa Takeshi Kawamura

A total of 25 patients with severe peritoneal dissemination underwent chemohyperthermic peritoneal perfusion (CHPP). The primary tumors in these patients comprised colorectal cancer (n = 14), ovarian cancer (n = 6), cervical cancer, (n = 1), small bowel cancer (n = 1), pseudomyxoma retroperitonei (n = 1), cystoadenocarcinoma of liver (n = 1), and pancreas cancer (n = 1). The intraperitoneal perfusion was carried out with a magnet pump for 60 min. The heated perfusate contained anticancer drugs to act synergistically with the hyperthermia. The intraperitoneal temperature was maintained at 42.0-42.5 degrees C. Eight of 25 patients showed CR, four PR, ten NC, and three PD, and the percentage (CR+PR) representing the overall efficacy rate was 48.0%. The morbidity rate was 8% (2/25) and there was no treatment-associated mortality. The percentage (CR+PR) of the patients with colorectal cancer was 57%; ovarian cancer, 50%; and other malignancies, 20%. The 1 year-and 3 year-survival rates of all the patients were 55% and 26%, respectively. The median survival periods of the CR, PR, NC, and PD groups were 4.0, 1.0, 1.0, and 0.7 years, respectively. The survival curve of the CR group was the best of all the groups (P = 0.02). These results indicated that CHPP was a feasible therapy and exerted a direct anticancer effect on peritoneal dissemination especially in the case of ovarian cancer, and the prognosis of complete responders was improved.

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Citations (55)

[A case of constrictive pericarditis due to traumatic pericardial hematoma].

PubMed (1990)

Takayoshi Adachi Noriko Kitamura M Otaki Takayuki Miki Yoshihisa Fukushima

Although the cause varies widely, we recently experienced a case of constrictive pericarditis of which cause seemed to be traumatic as described below. The patient was a 62-year-old man having a history of epigastric trauma about 20 years ago. Since then, palpitation appeared and he was recently hospitalized in our department for the purpose of receiving an operation under the diagnosis of constrictive pericarditis. At operation, a hematoma was found in the pericardial region, which was considered to have been caused by trauma in the past. Less reports have so far been available concerning trauma-induced constrictive pericarditis and this case thus seemed to be of rarity as well.

Pericardiectomy

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[Studies involving 11 cases of early gastric cancer with a widespread lymph node metastasis].

PubMed (1988)

Masahiro Matsushita Kitao HACHISUKA A Yamaguchi M Isogai Junji Kato

Over the past 10 years, we have experienced 11 cases of early gastric cancer limited to the mucosa and submucosa, with a widespread lymph node metastasis over the perigastric node. These cases represented 3.8% of all the early gastric cancer cases treated at our hospital during this period. The average age of these patients was 49.1 years, and consisted of 7 males and 4 females. Of these 11 cases, 10 cases (90.9%) were, macroscopically, the depressed type. Histologically, 7 cases (63.6%) were poorly differentiated carcinoma. Curative resections were possible in 8 cases (72.7%). The cumulative 5-year survival rate was poorer than for other types of early gastric cancer, and amounted to 66.7% in cases that were curative, and 0% for non-curative cases.

Submucosa

Gastric carcinoma

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Citations (2)

[A study of proliferative activities of gastric carcinomas using monoclonal antibody 780-3 (anti P-105): preliminary report].

PubMed (1989)

Yutaka Yonemura S Ooyama Hideyo Kimura T Kosaka A Yamaguchi

Gastric carcinoma

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Human chorionic gonadotropin in colorectal cancer and its relationship to prognosis

British Journal of Cancer (1989)

A Yamaguchi Tatsuhiro Ishida G Nishimura T Kumaki Makoto Katoh

Human chorionic gonadotropin

Immunoperoxidase

Grading (engineering)

Gonadotropin

10.1038/bjc.1989.289

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Citations (43)

Assessment of Tumor Cell Kinetics by Monoclonal Antibody Ki-67

European Surgical Research (1990)

Yutaka Yonemura Shigekazu Ohoyama Hironobu Kimura Tom Kamata A Yamaguchi

The expression of Ki-67 antigen in 71 patients with advanced gastric cancer was studied by immunohistochemical technique. Immunohistochemical staining with Ki-67 produced clear labeling of a portion of tumor cell nuclei, and the nucleoli stained intensely. The Ki-67 labeling rates of the 71 specimens ranged from 7.7 to 70.5% (mean: 29.2%; standard deviation: 12.9%). There was no significant association between Ki-67 labeling rates and macroscopic type, peritoneal metastasis, or serosal invasion. The tumors showing high Ki-67 labeling rates (greater than 25%) are more likely to have liver metastasis and lymph node involvement. Larger tumors, with a diameter greater than 6 cm, more frequently showed high Ki-67 labelling rate than those with a diameter less than 6 cm. When the Ki-67 labeling rate and 9 clinicopathologic parameters, as conventional prognostic factors, were entered simultaneously into the regression model, nodal status and Ki-67 labeling rate emerged as independent prognostic factors. These results indicate that the in situ determination of the growth fraction by Ki-67 antibody may be a reliable prognostic marker of advanced gastric cancer.

Ki-67

10.1159/000129123

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Citations (14)

A 65 nm CMOS technology with a high-performance and low-leakage transistor, a 0.55 μm/sup 2/ 6T-SRAM cell and robust hybrid-ULK/Cu interconnects for mobile multimedia applications

S. Nakai M. Kojima N. Misawa M. Miyajima Satoru Asai

This paper presents a 65 nm CMOS technology for mobile multimedia applications. The reduction of interconnect capacitance is essential for high-speed data transmission and small power consumption for mobile core chips. We have chosen a hybrid ULK structure which consists of NCS (nano-clustering silica; k=2.25) at the wire level and SiOC (k=2.9) at the via level. Although NCS is a porous material, the NCS/SiOC structure has sufficient mechanical strength to endure CMP pressure and wire bonding. Successfully fabricated 200 nm-pitch hybrid-ULK/Cu interconnects and a high-performance and low-leakage transistors meet the electrical targets from the circuit requirements. Moreover, an embedded 6T-SRAM with a 0.55 /spl mu/m/sup 2/ small cell size has been achieved.

Leakage (economics)

10.1109/iedm.2003.1269280

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Citations (19)

OVER-EXPRESSION OF P53 PROTEIN IN GASTRIC ADENOMA AND CANCER

International Journal of Oncology (1993)

Yutaka Yonemura Sachio Fushida Luís P. Fonseca Kouichiro Tsugawa Itasu Ninomiya

Recently, alterations of p53 gene in gastric cancer have been reported by several authors, but the role of p53-gene alterations in early step of carcinogenesis of gastric cancer remains unclear. To assess whether p53 expression is an early event in the carcinogenesis of gastric cancer, 402 gastric tumors (14 hyperplastic polyps, 48 gastric adenomas, 340 gastric cancers) were analyzed by immunohistochemistry using the specific antibody, PAb1801, against p53 oncoprotein. Five (15%) of 34 adenomas and 110 (32%) of 340 gastric cancers showed a definite positive nuclear staning for p53 protein. In contrast, the anti-p53 MAb did not show any specific staining in normal gastric epithelial cells, intestinal metaplasia or hyperplastic polyps. Out of nine adenomas showing mild dysplasia, only one tumor (11%) showed p53 expression. In contrast, 4 (16%) of 25 adenomas showing moderate dysplasia revealed positive p53 expression. In addition, positive p53 staining was not found in adenomas less than 1 cm in diameter, but five (25%) of 20 adenomas 1 cm or more in diameter showed definite p53-staining. In this way, the positive-p53 tissue status in adenomas was correlated with the dysplastic grade and size of adenomas. The incidence of positive-p53 immunoreaction in the differentiated type of cancers was 35% and showed no relation to wall invasion. On the contrary, p53 expression in the undifferentiated type of m-cancers, in which tumor invasion was limited to the mucosal layers, was detected in only one (5%) of 21 cases. Among undifferentiated type of gastric cancer, however, deeply invasive cancers showed higher p53-positive rate, as compared with m-cancer. These results may suggest p53 gene activation at a relatively early stage of the adenoma-carcinoma sequence, leading to the development of some differentiated adenocarcinomas in the stomach.

Intestinal metaplasia

Hyperplastic Polyp

Tubular adenoma

10.3892/ijo.3.3.497

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Citations (3)

[Genetic changes in liver metastasis of colorectal cancer and their clinical application].

PubMed (2001)

A Yamaguchi

It has been confirmed that several genes are involved in each step of liver metastasis of colorectal cancer. This article reviews recent highlights in this field. The expression of c-erbB2 or Rho protein in colorectal cancer tissues correlates closely with liver metastasis. Suppressor genes such as nm23, DCC, and DPC4 may play a role in the suppression of liver metastasis. On the other hand, the E-cadherin-catenin system, carbohydrate chains, selectin, and variant CD44 are known to play an important role in cells migration from the primary lesion, the adhesion of tumor cells to endothelial cells, and cell motility. These adhesion molecules may be a biological marker of liver metastasis. In addition, treatment targeting these genes will be a potent therapy for liver metastasis in the future.

Liver Cancer

Metastasis suppressor

Metastasis Suppressor Gene

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Citations (4)

[A case of iliac arterial embolism after lung cancer resection].

PubMed (1985)

H Watanabe Kitao HACHISUKA A Yamaguchi Shunsuke Kondo Ai Hori

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Citations (1)