L. Frank Glass

University of South Florida

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Jane L. Messina

Moffitt Cancer Center

Neil A. Fenske

University of South Florida

Basil S. Cherpelis

University of South Florida

Douglas S. Reintgen

University of South Florida

C. Wayne Cruse

Moffitt Cancer Center

Vernon K. Sondak

Moffitt Cancer Center

Lubomir Sokol

Moffitt Cancer Center

Glen M. Bowen

University of Utah

Marshall M. Urist

University of Alabama at Birmingham

Kishwer S. Nehal

Memorial Sloan Kettering Cancer Center

Cooperative Institutions

University of South Florida

154

Moffitt Cancer Center

124

Florida College

The University of Texas MD Anderson Cancer Center

University of Tampa

Harvard University

University of Washington

Memorial Sloan Kettering Cancer Center

James A. Haley Veterans' Hospital

Advanced Dermatology

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Subepidermal blistering disorders: a clinical and histopathologic review

Seminars in Cutaneous Medicine and Surgery (2003)

Ewa Kolanko Kelly Bickle Connie A. Keehn L. Frank Glass

The subepidermal blistering disorders are comprised of a number of unrelated disorders with a diverse clinical presentation and pathogenic basis that share in common the presence of blister formation beneath the epidermis. Many of the disorders are both debilitating and potentially fatal. Timely and accurate diagnosis facilitates their appropriate management. The etiologic, clinical, and pathologic attributes as well as the treatment of these disorders including bullous pemphigoid, epidermolysis bullosa acquisita, dermatitis herpetiformis, linear IgA dermatosis, cicatricial pemphigold, herpes gestationis,and porphyria cutanea tarda are described.

Dermatitis herpetiformis

Porphyria cutanea tarda

Epidermolysis bullosa acquisita

Milia

10.1016/s1085-5629(03)00083-x

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Citations (15)

Surgical Management of Melanoma-In-Situ Using a Staged Marginal and Central Excision Technique

Annals of Surgical Oncology (2008)

Mecker G. Möller Effie Pappas-Politis Jonathan S. Zager Luís Ângelo Macêdo Santiago Daohai Yu

Wide local excision

Lentigo maligna

10.1245/s10434-008-0239-x

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Citations (96)

The clinical relevance of sentinel lymph nodes identified with radiolymphoscintigraphy.

PubMed (1997)

Andrea Brobeil D Kamath C W Cruse D P Rapaport Karen Wells

The purpose of this case report is to illustrate the utility of radio-guided mapping of sentinel lymph nodes (SLN's) as demonstrated by the technique's successful identification of nodes containing metastatic disease that would have been left behind if only the visual-oriented vital blue dye mapping technique had been used.The patient underwent preoperative lymphoscintigraphy and intra-operative lymphatic mapping using vital blue dye and radiolymphoscintigraphy using the Neoprobe (handheld gamma probe). Nodes which were blue and/or "hot" (i.e., radioactive counts were three times the background count) were considered SLN's.Four SLN's were harvested, all of which were "hot" but only one of which was both "hot" and blue. Pathology revealed that the two SLN's positive for metastatic disease were not blue.While the blue dye lymphatic mapping technique provides the surgeon with a visual road map in the identification of SLN's, the Neoprobe increases the success rate of localization when compared to vital blue dye mapping due to the reliable migration of radiocolloid to the SLN's in the regional basin. Radiolymphoscintigraphy also increases the accuracy and efficiency of the SLN harvest by providing a directed dissection to the level of the nodes in the basin. The Neoprobe increases the yield of SLN's, some of which are clinically relevant since they contain metastatic disease.

Gamma probe

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Atypical spitz tumors

Melanoma Research (1997)

Raymond L. Barnhill Z. B. Argenyi Lynn From L. Frank Glass John C. Maize

Barnhill, R L; Argenyi, Z B; From, L; Glass, L F; Maize, J C; Mihm, M C; Piepkorn, M; Rabkin, M S; Ronan, S G; White, W L Author Information

10.1097/00008390-199706001-00431

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Citations (0)

Introduction: Advanced Cutaneous Malignancies

Seminars in Oncology (2012)

L. Frank Glass Ronald C. DeConti Vernon K. Sondak

10.1053/j.seminoncol.2012.01.012

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Distinction of Melanoma In Situ From Solar Lentigo on Sun-Damaged Skin Using Morphometrics and MITF Immunohistochemistry

American Journal of Dermatopathology (2011)

Will H Black Sumeet Thareja Brett Blake Ren Chen Basil S. Cherpelis

Distinction between melanoma in situ (MIS) and solar lentigo (SL) on chronically sun-damaged skin (CSDS) by hematoxylin and eosin (H&E) criteria alone can be difficult and in frozen section (FS) material, may be virtually impossible without immunohistochemistry (IHC). In this study, we used microphthalmia-associated transcription factor (MITF) IHC-directed image analysis to compare melanocyte nuclear morphometrics of MIS, SL, and sections of sun-damaged skin from redundant tissue acquired during Mohs micrographic surgery. The mean nuclear diameter and melanocytic density figures for MIS were greater than those for SL and CSDS by both independent t-test and analysis of variance statistics. No significant differences in these parameters were found between SL and sun-damaged skin. Cutoff values that favored MIS over SL included melanocyte density ≥10 nuclei per 200 μm, nuclear diameter ≥9 μm, and a product of density and diameter of 80 or more, as each of these values was associated with 100% specificity of MIS diagnosis. Our results suggest that image analysis of melanocytes labeled with MITF IHC can be used to produce morphometric data that distinguish MIS from SL and CSDS. The study was conducted using permanent sections, but previous studies with FSs indicate that the findings would apply to FSs as well. Quantitative assessment of melanocytic parameters using image analysis will likely become increasingly important as an adjunct to conventional histopathology for the diagnosis and surgical management of MIS on sun-damaged skin.

Microphthalmia-associated transcription factor

Histopathology

Morphometrics

10.1097/dad.0b013e3182093b13

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Citations (36)

Fibromucinous T-Cell Lymphoma

American Journal of Dermatopathology (2000)

Sharon I. Fairbee Michael B. Morgan Myron Tannenbaum L. Frank Glass

We report a case of mycosis fungoides associated with extensive dermal fibrosis and mucin deposition. The patient developed indurated plaques with diffuse tightening of the skin reminiscent of the sclerosing disorder scleromyxedema, which was later associated with nodules and lymphadenopathy. Skin biopsies showed diffusely thickened collagen bundles in the dermis and mucin deposition with a dense infiltrate of atypical lymphocytes with an immunophenotypic pattern indicative of mycosis fungoides. In our opinion, these clinical and histopathologic features are unusual for mycosis fungoides and can be construed as a distinct fibromucinous variant. Alternatively, this may represent a fibrosing reaction pattern similar to that described with systemic T- and B-cell lymphomas or a variety of inflammatory disorders.

10.1097/00000372-200012000-00006

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Citations (8)

Dermatofibrosarcoma ProtuberansPractice Guidelines in Oncology

Stanley J. Miller Murad Alam James Andersen Daniel Berg Christopher K. Bichakjian

Dermatofibrosarcoma

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Granulomatous slack skin: A possible precursor of Hodgkin's disease

Journal of the American Academy of Dermatology (1995)

Richard DeGregorio Neil A. Fenske L. Frank Glass