Allyson Ngo

University of California, Irvine

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Christopher Liang

University of California, Irvine

Jogeshwar Mukherjee

University of California, Irvine

Thomas G. Beach

Banner Sun Health Research Institute

Tony Nguyen

Clemson University

Dung Manh Tran

National Economics University

Steve W. Cole

University of California, Los Angeles

E. K. Wong

Chris O’Brien Lifehouse

Fariha Karim

University of California, Irvine

Stephanie Tran

Cardiovascular Medical Group

K. Vanichsarn

University of California, Irvine

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University of California, Irvine

University of California, Los Angeles

Salk Institute for Biological Studies

UCLA Health

Neurobehavioral Systems

Banner Sun Health Research Institute

Alzheimer's Association

Arizona Alzheimer’s Consortium

Research Network (United States)

University of Colorado Denver

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Synthesis and Evaluation of Compound Targeting α7 and β2 Subunits in Nicotinic Acetylcholinergic Receptor

Molecules (2023)

K. V. Singh Allyson Ngo Oshini V. Keerthisinghe Krystal K. Patel Christopher Liang

Nicotinic acetylcholine receptors (nAChRs) are involved in various central nervous system functions and have also been implicated in several neurodegenerative disorders. The heteromeric α4β2* and homomeric α7 are two major nAChR subtypes which have been studied in the brain using positron emission tomography (PET). Our comparative autoradiographic studies of the two receptor types in the mouse and rat brains show major differences in the thalamus (α4β2* >> α7), hippocampus (α7 >> α4β2*), and subiculum (α4β2* >> α7). A relatively newer heteromeric α7β2 nAChR subtype has been identified in the brain which may have a greater role in neurodegeneration. We report the development of KS7 (3-(2-(S)-azetidinylmethoxy)-5-(1,4-diaza-bicyclo[3.2.2]nonane)pyridine) which incorporates structural features of Nifzetidine (high affinity for α4β2* nAChR) and ASEM (high affinity for α7 nAChR) in an effort to target α7 and β2 subunits in α7β2 nAChR. KS7 exhibited higher affinities (IC50 = 50 to 172 nM) for [3H]cytisine radiolabeled sites and weaker affinities (IC50 = 10 μM) for [125I]-α-bungarotoxin radiolabeled rat brain sites in several brain regions. The weaker affinity of KS7 to α7 nAChR may suggest lack of binding at the α7 subunit of α7β2 nAChR. A radiolabeled derivative of KS7 may be required to identify any specific binding to brain regions suggested to contain α7β2 nAChR.

Homomeric

Cytisine

Epibatidine

10.3390/molecules28248128

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Abstract #4323 Adolescent cellular immune responses to acute stress: A preliminary study

Brain Behavior and Immunity (2019)

Allyson Ngo Zahra Mousavi Neda Semsar Steve W. Cole Michael R. Irwin

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10.1016/j.bbi.2019.08.107

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Monitoring Corneal Density Changes Using Optical Coherence Tomography in the Animal Model for Keratoconjunctivitis Sicca

Investigative Ophthalmology & Visual Science (2010)

Matthew Ficinski K. Vanichsarn Z. Deng Dung Manh Tran Stephanie Tran

KERATOCONJUNCTIVITIS SICCA

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[18F]Flotaza for Aβ Plaque Diagnostic Imaging: Evaluation in Postmortem Human Alzheimer’s Disease Brain Hippocampus and PET/CT Imaging in 5xFAD Transgenic Mice

International Journal of Molecular Sciences (2024)

Yasmin K. Sandhu Harman S. Bath Jasmine Shergill Christopher Liang Amina U. Syed

The diagnostic value of imaging Aβ plaques in Alzheimer's disease (AD) has accelerated the development of fluorine-18 labeled radiotracers with a longer half-life for easier translation to clinical use. We have developed [

PET Imaging

Postmortem studies

Human brain

10.3390/ijms25147890

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Citations (3)