Jianning Yao

First Affiliated Hospital of Zhengzhou University

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Chunfeng Wang

Shenzhen University

Xuexiu Zhang

First Affiliated Hospital of Zhengzhou University

Haining Zhou

Suizhou Central Hospital

Jinlin Xie

University of Science and Technology of China

Xiaonan Yang

Guangxi Medicinal Botanical Garden

Lianfeng Zhang

Huainan Normal University

Zhang Lian-feng

Chinese Academy of Medical Sciences & Peking Union Medical College

Zhaoxiang Song

Shanghai Institute of Materia Medica

Yanzhen Zhang

China University of Petroleum, East China

Fei Han

Soochow University

Cooperative Institutions

First Affiliated Hospital of Zhengzhou University

Zhengzhou University

Chinese Academy of Sciences

Nanjing Medical University

Zhejiang University

Chinese Academy of Medical Sciences & Peking Union Medical College

Huazhong University of Science and Technology

Shanghai Jiao Tong University

Third Affiliated Hospital of Zhengzhou University

Nanjing University

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Laparoscopic antireflux surgery or PPIs in the management of reflux-related esophageal stricture

Surgical Endoscopy (2022)

Zhitong Li Xianglin Kong Rui Zhang Jianning Yao Chunxia Li

Abstract Background Gastroesophageal reflux disease (GERD) is often associated with esophageal stricture, particularly benign esophageal stricture. We aimed to evaluate the effects of balloon catheter dilation (BD) combined with laparoscopic fundoplication (LF) surgery and proton pump inhibitors (PPIs) in patients with reflux-induced esophageal strictures. Methods We retrospectively analyzed 116 patients with reflux-induced benign esophageal strictures who underwent balloon dilatation therapy combined with PPIs (BD-PPIs group, n = 58) and balloon dilatation combined with LF (BD-LF group, n = 58). Patients were followed up for 24 months. The outcomes of the patients were monitored, including clinical success, symptom improvement, adverse events, and the frequency of esophagitis. Results At the latest follow-up, the rate of clinical success was higher in BD-LF group than in BD-PPIs group (80.4% vs. 57.7%, P = 0.011). The patients in the BD-PPIs group required more dilation sessions to achieve successful dilation, as compared to those in the BD-LF group (2.1 ± 1.2 vs. 0.7 ± 0.8, P < 0.001). The DeMeester score, number of reflux episodes for which pH was < 4, and lower esophageal sphincter pressure were significantly better in the BD-LF group than in the BD-PPIs group (all P < 0.001). The incidence of reflux esophagitis was higher in the BD-PPIs group than in the BD-LF group, at 24 months (58.8% vs. 18.2%, P = 0.003). Conclusions Balloon dilatation with concomitant LF is effective and safe for esophageal stricture secondary to GERD. Moreover, antireflux surgery techniques, such as Nissen or Toupet procedure, should be added for reflux-induced benign esophageal stricture.

Reflux esophagitis

Esophageal stricture

Balloon dilation

Esophagitis

Esophageal pH monitoring

Nissen fundoplication

10.1007/s00464-022-09564-5

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Cytochrome P450-Mediated Bioactivation: Implication for the Liver Injury Induced by Fraxinellone, A Bioactive Constituent from Dictamni Cortex

Chemical Research in Toxicology (2020)

Haining Zhou Qingwang Liu Juan Zhang Jianning Yao Chunfeng Wang

Fraxinellone, a furanoid, is one of the bioactive and potentially hepatotoxic constituents from Dictamnus dasycarpus Turcz, which is extensively spread throughout Asian countries. This herb was reported to cause liver injury in clinical application. However, the mechanism behind is still not fully understood. This study mainly focused on the hepatotoxicity of fraxinellone and the underlying mechanism. The current study demonstrated that fraxinellone resulted in a significant elevation of serum alanine aminotransferase and aspartate aminotransferase in a dose-dependent manner in mice after oral administration. Pretreatment with ketoconazole for three successive days could significantly alleviate the hepatotoxicity of fraxinellone. Considering that fraxinellone has a structural alert of furan ring, it is believed that the hepatotoxicity caused by fraxinellone required cytochrome P450-mediated bioactivation. Bioactivation studies were subsequently carried out in vitro and in vivo. Fraxinellone was metabolized into cis-enedial intermediate, an electrophile that was prone to react with glutathione or N-acetyl-lysine through 1,2- or 1,4-addition to form stable conjugates. Ketoconazole significantly inhibited the formation of the glutathione conjugates (M1 and M2) in microsomal incubation and similar finding was obtained in vivo. Phenotyping study indicated that CYP3A4 was the principal enzyme responsible for the bioactivation of fraxinellone. This study suggested that CYP3A4-mediated bioactivation plays an indispensable role in fraxinellone-induced hepatotoxicity. The work performed herein enables us to better understand the hepatotoxicity of fraxinellone as well as the mechanism behind.

10.1021/acs.chemrestox.0c00141

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Endoscopic management of foreign bodies in the upper gastrointestinal tract: a retrospective study on 570 cases

Central Plains Medical Journal (2020)

Xiaodi Jing Xuexiu Zhang Xiaofang Guo Bing Gao Jianning Yao

Objective To investigate the pathogenesis and treatment of foreign bodies in the upper digestive tract in the Central Plain of China. Methods A total of 570 patients with foreign bodies in the upper gastrointestinal tract treated in the First Affiliated Hospital of Zhengzhou University from March 2015 to March 2019 were selected. The types of foreign bodies, location of impaction, complications, selection of instruments and methods of removal of them were analyzed retrospectively. Results Among the 570 patients, 323 persons were males and 247 persons were females, with an average age of 47 years. Date pits were the most common ingested foreign bodies (24.2%, 138/570), and the esophagus was the most common lodgment site (73.2%, 417/570). Time from foreign incarceration to treatment was 6 h to 30 d, and the average hospitalization rate was 62.3% (339/570). The primary clinical symptom was retrosternal pain. The complication rate was (58.1%, 331/570), which was relatively high. Two patients underwent surgery to remove foreign bodies for esophageal perforation, and one pationt died due to treatment failure. Conclusions Endoscopic management is a safe and highly effective procedure for extracting ingested foreign bodies. Rapid endoscopic intervention should be provided to reduce the risk of complications. Key words: Foreign body; Upper digestive tract; Endoscopy

Perforation

Impaction

Digestive tract

10.3760/cma.j.issn.1674-4756.2020.05.007

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Optimized Stratification of Recurrence Risk in Stage I Non-Small Cell Lung Cancer Via Ai Hybrid Model: A Multicenter Cohort Study

Liying Wang Yu Zong Lijun Huang Hao Tang Jianning Yao

Risk Stratification

Stratification (seeds)

Prognostic model

10.2139/ssrn.5108439

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<p>Long Non-Coding RNA HOTAIR Modulates KLF12 to Regulate Gastric Cancer Progression via PI3K/ATK Signaling Pathway by Sponging miR-618</p>

OncoTargets and Therapy (2019)

Xun Jin Chunfeng Wang Jianning Yao Bing Gao Lianfeng Zhang

Purpose: Long non-coding RNA (lncRNA) HOX transcript antisense RNA (HOTAIR) has been reported to dysregulate in many tumors. However, the mechanism of HOTAIR was rarely reported in GC. Methods: The levels of HOTAIR, microRNA-618 (miR-618) and Krueppel-like factor 12 (KLF12) in GC tissues and cells were detected by quantitative real-time polymerase chain reaction (qRT-PCR). The cell viability and apoptotic rate were assessed via cell counting kit-8 (CCK-8) assay and flow cytometry, respectively. The migrating and invading abilities were tested by Transwell assay. The protein levels of KLF12, p-PI3K, PI3K, p-ATK and ATK were measured by Western blot assay. These interactions between miR-618 and HOTAIR or KLF12 were predicted by DIANA tools, and then, dual-luciferase reporter assay and RNA immunoprecipitation (RIP) assay were conducted to validate these interactions. Besides, the xenograft tumor experiment was performed to further verify the roles of HOTAIR in GC. Results: The levels of HOTAIR and KLF12 were significantly upregulated and the level of miR-618 was strikingly downregulated in GC tissues and cells. miR-618 was verified as a direct target of HOTAIR or KLF12. HOTAIR silencing blocked GC progression and PI3K/ATK signaling pathway by sponging miR-618 and also restrained xenograft tumor growth in vivo. miR-618 inhibited GC progression and PI3K/ATK signaling pathway by targeting KLF12. Mechanistically, HOTAIR modulated KLF12 expression by sponging miR-618 in GC cells. Conclusion: These data unraveled that HOTAIR promoted GC progression through PI3K/ATK signaling pathway via miR-618/KLF12 axis. Keywords: HOTAIR, miR-618, KLF12, PI3K/ATK signaling pathway, gastric cancer

HOTAIR

Competing Endogenous RNA

10.2147/ott.s223957

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Localizing and Identifying Intestinal Metaplasia Based on Deep Learning in Oesophagoscope

Cong Wang Ya Li Jianning Yao Bing Chen Jiayou Song

Intestinal metaplasia is a precancerous lesion, gastric cancer is a very common malignant tumor, and many people die every year from stomach cancer. Early diagnosis of gastric cancer is critical to reducing patient mortality and overall medical burden. However, traditional endoscopic intestinal metaplasia on the gastric mucosa lacks specific performance. Consequently, subtle changes in precancerous intestinal metaplasia are not obvious limiting diagnostic accuracy. As a clinical computer aid in the diagnosis of early gastric cancer, a deep learning framework model called W-Deeplab was proposed for the identification and localization of intestinal metaplasia lesions. It achieves high-precision semantic segmentation of endoscopic images. As a computer aid to clinicians, it can improve the accuracy and efficiency of intestinal metaplasia diagnosis and reduce misdiagnosis.

Intestinal metaplasia

Precancerous lesion

Limiting

Metaplasia

Precancerous condition

10.1109/isne.2019.8896546

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Citations (11)

microRNA-141-3p fosters the growth, invasion, and tumorigenesis of cervical cancer cells by targeting FOXA2

Archives of Biochemistry and Biophysics (2018)

Jia-Heng Li Zhan Zhang Mingze Du Yichun Guan Jianning Yao

Ectopic expression

10.1016/j.abb.2018.09.008

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Citations (49)

Molecular and cellular mechanisms of tight junction dysfunction in the irritable bowel syndrome

Molecular Medicine Reports (2015)

Cheng Peng Jianning Yao Chunfeng Wang Lianfeng Zhang Wu-ming Kong

The pathophysiological mechanisms of the irritable bowel syndrome (IBS), one of the most prevalent gastrointestinal disorders, are complex and have not been fully elucidated. The present study aimed to investigate the molecular and cellular mechanisms of tight junction (TJ) dysfunction in IBS. Intestinal tissues of IBS and non‑IBS patients were examined to observe cellular changes by cell chemical tracer electron microscopy and transmission electron microscopy, and intestinal claudin‑1 protein was detected by immunohistochemistry, western blot analysis and fluorescence quantitative polymerase chain reaction. Compared with the control group, TJ broadening and the tracer extravasation phenomenon were observed in the diarrhea‑predominant IBS group, and a greater number of neuroendocrine cells and mast cells filled with high‑density particles in the endocrine package pulp as well as a certain extent of vacuolization were present. The expression of claudin‑1 in diarrhea‑predominant IBS patients was decreased, while it was increased in constipation‑predominant IBS patients. In conclusion, the results of the present study indicated that changes in cellular structure and claudin‑1 levels were associated with Tjs in IBS.

Pathophysiology

Claudin

Occludin

10.3892/mmr.2015.3808

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Citations (41)

Sanggenon C induces apoptosis of colon cancer cells via inhibition of NO production, iNOS expression and ROS activation of the mitochondrial pathway

Oncology Reports (2017)

Lidong Chen Zhihui Liu Lianfeng Zhang Jianning Yao Chunfeng Wang

Sanggenon C is a well-known, major active agent of the flavonoid derivative of benzopyrone with valuable biological properties, including anticancer, anti-inflammatory, antimicrobial, antiviral, antithrombotic, and immune-modulatory activities. In this study, we investigated the molecular mechanisms by which sanggenon C mediated the induction of cell death in colorectal cancer cells (CRC). Treatment of colorectal cancer cells (LoVo, HT-29 and SW480) with sanggenon C (0, 5, 10, 20, 40 and 80 µM) resulted in inhibited proliferation of colon cancer cells. In addition, Sanggenon C (10, 20, 40 µM) induces apoptosis of HT-29 colon cancer cells as well as the increased ROS generation. Furthermore, treatment with sanggenon C increased the level of intracellular Ca2+ and ATP, while inhibited the nitric oxide production via inhibiting inducible nitric oxide synthase expression. This resulted in the activation of mitochondrial apoptosis pathway as evidenced by the decrease in Bcl-2 protein expression. Consistently, the anti-growth and pro-apoptosis effects of sanggenon C on xenograft colon tumor were further confirmed in vivo. Collectively, our results demonstrated sanggenon C induced apoptosis of colon cancer cells by increased reactive oxygen species generation and decreased nitric oxide production, which is associated with inhibition of inducible nitric oxide synthase expression and activation of mitochondrial apoptosis pathway.

10.3892/or.2017.5912

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Additional file 1 of A novel endoplasmic reticulum stress-related lncRNA signature for prognosis prediction and immune response evaluation in Stomach adenocarcinoma

Figshare (2023)

Zhaoxiang Song Mengge Su Xiangyu Li Jinlin Xie Fei Han

Additional file 1. The List of 330 ERS‑related genes.

Signature (topology)

10.6084/m9.figshare.24779258

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