L.-A. Etherington

Ninewells Hospital

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Jeremy J. Lambert

University of Dundee

Tanja van Mourik

University of St Andrews

Keith T. Sillar

University of St Andrews

Alexandra M. Z. Slawin

University of St Andrews

David O′Hagan

University of St Andrews

Tomáš Lébl

University of St Andrews

J Issberner

University of St Andrews

J.M. Heygate

University of St Andrews

Guy Deniau

Commissariat à l'Énergie Atomique et aux Énergies Alternatives

F. Chorki

Cooperative Institutions

Egis Pharmaceuticals (Hungary)

Egis (France)

University of St Andrews

Servier (France)

Semmelweis University

Centre National de la Recherche Scientifique

St. Andrews University

Hungarian Academy of Sciences

University of Edinburgh

Budapest University of Technology and Economics

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CCDC 652765: Experimental Crystal Structure Determination

The Cambridge Structural Database (2008)

Guy Deniau Alexandra M. Z. Slawin Tomáš Lébl F. Chorki J Issberner

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/ccpx7yr

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A novel GABAA alpha 5 receptor inhibitor with therapeutic potential

European Journal of Pharmacology (2015)

István Ling Balázs Mihalik L.-A. Etherington Gábor Kapus Adrienn Pálvölgyi

Moiety

Isoquinoline

10.1016/j.ejphar.2015.07.005

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Synthesis, Conformation and Biological Evaluation of the Enantiomers of 3‐Fluoro‐γ‐Aminobutyric Acid ((R)‐ and (S)‐3F‐GABA): An Analogue of the Neurotransmitter GABA

ChemBioChem (2007)

Gildas Deniau Alexandra M. Z. Slawin Tomáš Lébl Fatima Chorki J Issberner

Gamma-aminobutyric acid or GABA (1) is one of the major inhibitory amino acid neurotransmitters of the central nervous system. This article describes the first synthesis of both the (R)- and (S)- enantiomers of 3-fluoro-GABA (2, 3F-GABA). DFT calculations were carried out in a continuum solvent model (PCM-B3LYP) to estimate the preferred conformations of 3F-GABA in aqueous solution. NMR coupling constants were calculated for each conformer and were then used to simulate the NMR spectra to evaluate the solution conformation of 3F-GABA. A preliminary evaluation of the 3F-GABA enantiomers shows that they act similarly as agonists of cloned GABA(A) receptors; however, they behave quite differently in a whole animal (Xenopus laevis tadpole model).

Aminobutyric acid

Gamma-Aminobutyric Acid

Conformational isomerism

GABA receptor

10.1002/cbic.200700371

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Citations (66)

Testosterone/dihydrotestosterone kit method for diagnostic use.

Clinical Chemistry (1985)

L.-A. Etherington

Journal Article Testosterone/dihydrotestosterone kit method for diagnostic use. Get access L Etherington L Etherington Search for other works by this author on: Oxford Academic Google Scholar Clinical Chemistry, Volume 31, Issue 1, 1 January 1985, Page 167, https://doi.org/10.1093/clinchem/31.1.167 Published: 01 January 1985

Dihydrotestosterone

10.1093/clinchem/31.1.167

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CCDC 652766: Experimental Crystal Structure Determination

The Cambridge Structural Database (2008)

Guy Deniau Alexandra M. Z. Slawin Tomáš Lébl F. Chorki J Issberner

10.5517/ccpx7zs

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CCDC 652767: Experimental Crystal Structure Determination

The Cambridge Structural Database (2008)

Guy Deniau Alexandra M. Z. Slawin Tomáš Lébl F. Chorki J Issberner

10.5517/ccpx80v

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