The observation that obesity, dyslipidemia, diabetes and hypertension occur simultaneously in many people was first made by Crepaldi in 1967. In the late 1970s this clustering of conditions was termed "metabolic syndrome" by German researchers. Since then the syndrome has been described under a number of guises as "Insulin resistance syndrome", "Syndrome X", "Plurimetabolic syndrome" and the "Metabolic syndrome". The syndrome is a multi-component disease brought on by combination of lifestyle and environmental factors, with some populations exhibiting a genetic susceptibility for its development.
Introduction: Many investigators have tried to identify a simple blood test or predicting rules that can help physicians to make more rational decisions to identify patients who are at risk for adverse outcomes or death. Aim: The aim of this study was to investigate the prognostic value of plasma D-dimer, CRP and some other biomarkers levels in patients with CAP. Materials and Methods: In this study were enrolled 72 patients admitted on Sept - Dec 2011 with clinical and radiological evidence of CAP. Within 24 hours after admission and on the 4-th day blood samples were taken for analysis. CURB-65 and PSI severity scores were calculated at admission. Statistical analysis is made with SPSS 19.0. Results: Mean age 62.7±16.6 years(range 25-92).Mean D-dimer on the first day resulted 2621ng/ml(range 296-9000),on the 4-th day 2585 ng/ml (range120-9000). Mean CRP on the first day resulted 198 mg/l(range 0.76 - 743),on the 4-th day 72 mg/l(range 0.10 - 316). On admission mean value of fibrinogen was 811mg/dl(range 279-1780); APTT– 37.39 sec (range 17- 100); leukocyte –15363 (range 1900- 47200); ESR-28 mm/hr(range 2-68);fever – 37.8oC (range 36.4- 41). Mean hospitalization 9.65 days (range 0- 35).Mean values of D-dimer and CRP resulted in correlation with complications events. Even though mean values of D-dimer and CRP are higher, no significant correlations resulted between them and CURB-65 and PSI score. Significantly mean values of D-dimer and CRP are higher on groups of patients with complicated CAP(p Conclusion: D-dimer and CRP level cannot replace CURB-65 or PSI scoring for assessment in CAP patients, but are useful to predict clinical outcome, especially complications in pacients with CAP.
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Diakou M, Miltiadous G, Xenophontos S, et al. Original research Characterization of low density lipoprotein receptor (LDLR) gene mutations in Albania. Archives of Medical Science. 2010;6(2):198-200. doi:10.5114/aoms.2010.13894. APA Diakou, M., Miltiadous, G., Xenophontos, S., Cariolou, M., Heta, N., & Korita, I. et al. (2010). Original research Characterization of low density lipoprotein receptor (LDLR) gene mutations in Albania. Archives of Medical Science, 6(2), 198-200. https://doi.org/10.5114/aoms.2010.13894 Chicago Diakou, Maria, George Miltiadous, Stavroula Xenophontos, Marios Cariolou, Nevila Heta, Irena Korita, and Anyla Bulo et al. 2010. "Original research Characterization of low density lipoprotein receptor (LDLR) gene mutations in Albania". Archives of Medical Science 6 (2): 198-200. doi:10.5114/aoms.2010.13894. Harvard Diakou, M., Miltiadous, G., Xenophontos, S., Cariolou, M., Heta, N., Korita, I., Bulo, A., Refatllari, E., Bairaktari, E., and Elisaf, M. (2010). Original research Characterization of low density lipoprotein receptor (LDLR) gene mutations in Albania. Archives of Medical Science, 6(2), pp.198-200. https://doi.org/10.5114/aoms.2010.13894 MLA Diakou, Maria et al. "Original research Characterization of low density lipoprotein receptor (LDLR) gene mutations in Albania." Archives of Medical Science, vol. 6, no. 2, 2010, pp. 198-200. doi:10.5114/aoms.2010.13894. Vancouver Diakou M, Miltiadous G, Xenophontos S, Cariolou M, Heta N, Korita I et al. Original research Characterization of low density lipoprotein receptor (LDLR) gene mutations in Albania. Archives of Medical Science. 2010;6(2):198-200. doi:10.5114/aoms.2010.13894.