The aim of this cross-sectional study was to determine the prevalence of metabolic syndrome (MetS) and its components among 100 patients with progressive peripheral arterial disease (PAD) referred for diagnostic angiography in preparation for a revascularization procedure. The prevalence of MetS was more than 95%. Diabetes mellitus was the most prevalent component followed by hypertension and low high-density lipoprotein. Almost half the patients aggregated in the highest metabolic score category. A direct relationship was identified between the number of MetS components and serum uric acid (P = .001) and C-reactive protein (P = .826), whereas an inverse relationship was seen between the clustering of components and androgen levels in men (P < .001). For PAD, which could have a benign clinical course, early screening for MetS might identify those at greater risk of failing conservative therapy and progressing to a more aggressive atherosclerotic disease typically associated with high morbidity and mortality.

10.1177/0003319707304582

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Role of Lactoferrin in Prevention of Premature Rupture of Membranes

The Egyptian Journal of Hospital Medicine (2024)

Mohammed Abd Elhady Mohammed Amr Ali Sharaf Eldeen Amira Ahmed

Background: The development of the fetal membranes "amnion and chorion" begins with embryogenesis, although they do not have a direct role in the formation of the embryo or fetus.Objective: This study aimed to decrease the morbidities and mortalities resulting from premature rupture of membranes (PROM.).Patients and methods: This was a cohort study conducted on 90 patients at Department of Obstetrics and Gynecology in Benha University Hospital and Zagazig General Hospital through the period from November 2022 to November 2023.Results: A notable divergence was observed concerning the cervical length, with the first measurement yielding a p-value of 0.005 and the second measurement yielding a p-value of 0.01.Furthermore, a significant disparity was noted in the gestational age at the time of termination, as evidenced by a p-value of 0.029.When evaluating the effectiveness of lactoferrin (LF) in averting membrane rupture, lactoferrin demonstrated a sensitivity of 75.6%, a specificity of 57.8%, and predictive values for positive and negative outcomes of 64.2% and 70.3% respectively, albeit with a non-significant p-value of 0.163.In terms of neonatal vital signs (including pulse rate and respiratory rate) and neonatal weight, no significant differences were discerned, as indicated by p-values of 0.69, 0.545, 0.013, and 0.091, respectively.Conclusion: Augmentation through lactoferrin supplementation presents a conceivable strategy to diminish the incidence of PROM.Additional research is imperative to substantiate the preliminary evidence, which offers a significant conceptual foundation for the prospective utilization of lactoferrin in thwarting preterm childbirth.

Lactoferrin

10.21608/ejhm.2024.349086

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