Mehmet Uyar

Ege University

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Kubilay Demırağ

Ege University

İÇ

İlkin Çankayalı

Ege University

Canan Bor

Ege University

Esra Akın Korhan

Izmir Kâtip Çelebi University

İK

İclal Karaca

Ege University

Mustafa Cömert

Bülent Ecevit University

Leyla Khorshıd

Ege University

SÖ

Sezer Öcal

İstanbul Eğitim ve Araştırma Hastanesi

Onur Gündoğan

Türk Anesteziyoloji ve Reanimasyon Derneği

İY

İlker Yıldırım

Namık Kemal University

Cooperative Institutions

Ege University

Sağlık Bilimleri Üniversitesi

Türk Anesteziyoloji ve Reanimasyon Derneği

Ege Üniversitesi Tıp Fakültesi Hastanesi

Kocaeli Üniversitesi

Izmir University

Imation (United States)

Marmara University

University of Health Science

Sakarya University

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Evaluation of the Effectiveness of Convalescent Plasma Therapy in Severe and Critical COVID-19 Patients

Türk yoğun bakım derneği dergisi/Türk yoğun bakım dergisi (2024)

Özhan Özcan İlkin Çankayalı Ajda Turhan Mehmet Sezai Taşbakan Hüseyin Aytaç Erdem

Objective: Relevant studies have suggested that the administration of convalescent plasma (CP) collected from COVID-19 patients who have recovered from the infection and whose plasma contains antibodies against SARS-CoV-2 is safe and may be effective in treating COVID-19 patients.The present study aimed to investigate whether the number of CP doses administered, the power of the IgG ratio and the time of CP administration following positive SARS-CoV-2 PCR had an impact on the 30-day in-hospital mortality.Materials and Methods: This single-center retrospective study was conducted with patients who were hospitalized and met the severe/critical COVID-19 disease criteria and received CP .Demographics, comorbidities, co-medications, onset of symptoms, duration between SARS-CoV-2 PCR testing and hospitalization, the time of the first CP administration, laboratory results, respiratory support needs, O2 saturation, fever at the baseline, APACHE II scores and SOFA scores were recorded.Results: Of the 224 patients with the mean age of 64.2±14.5 (19-91) years, 143 were male.The most common comorbidities were hypertension and congestive heart failure.Chronic renal failure, mechanical ventilation needs, PO2/FiO2 <300, clinically rapid progression, persistent fever, SOFA score increase and increased vasopressor need were associated with increased mortality.There was a statistically significant difference between the deceased (14.0±8.2) and survivor (8.74±5.28)groups in terms of APACHE II scores (p<0.001).The number of CP units administered, the power of the IgG ratio in the CP units and the timing of CP administration had no effect on the need for respiratory support and mortality rate.CP-associated complications were observed in 11 (0.5%) patients. Conclusion:In conclusion, CP therapy was not associated with improved survival or other positive clinical outcomes in severe/critical COVID-19 patients.Keywords: severe/critical

Convalescent plasma

2019-20 coronavirus outbreak

10.4274/tybd.galenos.2023.58815

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Baclofen Intoxication

Türk yoğun bakım derneği dergisi/Türk yoğun bakım dergisi (2015)

Canan Bor İclal Karaca Özge Karakoç İlkin Çankayalı Kubilay Demırağ

Baclofen

10.4274/tybdd.86580

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Citations (1)

Reflexology

Holistic Nursing Practice (2013)

Esra Akın Korhan Leyla Khorshıd Mehmet Uyar

To investigate whether reflexology has an effect on the physiological signs of anxiety and level of sedation in patients receiving mechanically ventilated support, a single blinded, randomized controlled design with repeated measures was used in the intensive care unit of a university hospital in Turkey. Patients (n = 60) aged between 18 and 70 years and were hospitalized in the intensive care unit and receiving mechanically ventilated support. Participants were randomized to a control group or an intervention group. The latter received 30 minutes of reflexology therapy on their feet, hands, and ears for 5 days. Subjects had vital signs taken immediately before the intervention and at the 10th, 20th, and 30th minutes of the intervention. In the collection of the data, "American Association of Critical-Care Nurses Sedation Assessment Scale" was used. The reflexology therapy group had a significantly lower heart rate, systolic blood pressure, diastolic blood pressure, and respiratory rate than the control group. A statistically significant difference was found between the averages of the scores that the patients included in the experimental and control groups received from the agitation, anxiety, sleep, and patient-ventilator synchrony subscales of the American Association of Critical-Care Nurses Sedation Assessment Scale. Reflexology can serve as an effective method of decreasing the physiological signs of anxiety and the required level of sedation in patients receiving mechanically ventilated support. Nurses who have appropriate training and certification may include reflexology in routine care to reduce the physiological signs of anxiety of patients receiving mechanical ventilation.

Reflexology

Vital signs

Respiratory Rate

10.1097/hnp.0000000000000007

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Citations (25)

The Effect of Lactate, Albumin, C-reactive Protein, PaO2/FiO2 and Glucose Levels of Trauma Patients at the Time of Administration to Intensive Care

Türk yoğun bakım derneği dergisi/Türk yoğun bakım dergisi (2014)

Eren Yılmaz Canan Bor Mehmet Uyar Kubilay Demırağ İlkin Çankayalı

ÖZET Amaç: Travma hastalarının yoğun bakım gözleminde kan analizlerinin kullanımı tercih edilir.Bu çalışmanın amacı travma hastalarının yoğun bakıma kabulündeki albumin, C-reaktif protein (CRP), PaO 2 /FiO 2 ve glukoz düzeylerinin mortalite ile ilişkisinin araştırılmasıdır.Gereç ve Yöntem: 2010-2012 yılları arasında travma sonucu yoğun bakıma kabul edilen hastalar retrospektif olarak araştırıldı

10.4274/tybdd.02411

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Citations (3)

The effect of oropharyngeal aspiration before position change on reducing the incidence of ventilator- associated pneumonia

European Journal of Clinical Microbiology & Infectious Diseases (2020)

Ayşe Akbıyık Ziynet Hepçivici İsmet Eşer Mehmet Uyar Perihan Çetin

Ventilator-associated Pneumonia

Stenotrophomonas maltophilia

Acinetobacter baumannii

10.1007/s10096-019-03789-4

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Citations (8)

Pain Assessment in Critically İll Adult Patients: Validity and Reliability Research of the Turkish Version of the Critical-Care Pain Observation Tool

Türk yoğun bakım derneği dergisi/Türk yoğun bakım dergisi (2016)

Onur Gündoğan Canan Bor Esra Akın Korhan Kubilay Demırağ Mehmet Uyar

Amaç: Yoğun Bakım Ağrı Gözlem Ölçeği (YBAGÖ) (Critical Care Pain Observation Tool-CPOT) ve Davranışsal Ağrı Ölçeği (DAÖ) bilinci kapalı yoğun bakım ünitesi (YBÜ) hastalarında kullanılan davranışsal ağrı değerlendirme ölçekleridir

Validity

10.4274/tybdd.95967

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Citations (6)

Clinical Characteristics, Outcomes, and Risk Factors for Mortality in Pregnant/Puerperal Women with COVID-19 Admitted to ICU in Turkey: A Multicenter, Retrospective Study from a Middle-Income Country

Journal of Intensive Care Medicine (2024)

Nur Baykara Nur Baykara Mustafa Kemal Arslantaş Volkan Hancı Halis Akalın

Background Coronaviruses have been the cause of 3 major outbreaks during the last 2 decades. Information on coronavirus diseases in pregnant women is limited, and even less is known about seriously ill pregnant women. Data are also lacking regarding the real burden of coronavirus disease 2019 (COVID-19) infection in pregnant women from low/middle-income countries. The aim of this study was to determine the characteristics and clinical course of COVID-19 in pregnant/puerperal women admitted to ICUs in Turkey. Methods This was a national, multicenter, retrospective study. The study population comprised all SARS-CoV-2-infected pregnant/puerperal women admitted to participating ICUs between 1 March 2020 and 1 January 2022. Data regarding demographics, comorbidities, illness severity, therapies, extrapulmonary organ injuries, non-COVID-19 infections, and maternal and fetal/neonatal outcomes were recorded. LASSO logistic regression and multiple logistic regression analyses were used to identify predictive variables in terms of ICU mortality. Results A total of 597 patients (341 pregnant women, 255 puerperal women) from 59 ICUs in 44 hospitals were included and of these patients, 87.1% were unvaccinated. The primary reason for ICU admission was acute hypoxemic respiratory failure in 522 (87.4%), acute hypoxemic respiratory failure plus shock in 14 (2.3%), ischemic cerebrovascular accident (CVA) in 5 (0.8%), preeclampsia/eclampsia/HELLP syndrome in 6 (1.0%), and post-caesarean follow-up in 36 (6.0%). Nonsurvivors were sicker than survivors upon ICU admission, with higher APACHE II ( p < 0.001) and SOFA scores ( p < 0.001). A total of 181 (30.3%) women died and 280 (46.6%) had received invasive mechanical ventilation (IMV). Myocardial injury, the highest SOFA score during ICU stay, LDH levels on admission, the highest levels of AST during ICU stay, average daily dose of corticosteroids, IMV, prophylactic dose anticoagulation (compared with therapeutic dose anticoagulation), PaO 2 /FiO 2 ratio <100, pulmonary embolism, and shock were identified as predictors of mortality. Rates of premature birth (46.4%), cesarean section (53.7%), fetal distress (15.3%), stillbirth (6.5%), and low birth weight (19.4%) were high. Rates of neonatal death (8%) and respiratory distress syndrome (21%) were also high among live-born infants. Conclusions Severe/critical COVID-19 infection during the pregnancy/puerperal period was associated with high maternal mortality and fetal/neonatal complication rates in Turkey.

HELLP syndrome

SOFA score

10.1177/08850666231222838

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Citations (1)

Tenofovir disoproxil fumarate in the treatment of COVID-19: Evaluation of 78 patients.

PubMed (2024)

Gamze Şanlıdağ Isabel Raika Durusoy Onmuş Ilkin Çankayalı Kubilay Demirağ Mehmet Uyar

One of the drugs that has been suggested for the treatment of SARS-CoV-2 infection is tenofovir disoproxil (TDF). Herein, it was aimed to evaluate the outcomes of TDF receiving COVID-19 cases in terms of day 7-10 PCR negativity and day 30 survival. Patients who received TDF due to PCR-confirmed COVID-19 between 27.04.2021 and 31.12.2021 were included in our study. The primary outcome was considered to be 7-10 days of PCR negativity, while the secondary outcome was considered 30-day survival after diagnosis of COVID-19. Patients who died before completing the treatment period (7-10 days) were also considered as PCR failures. Data were analyzed both in terms of intention to treat basis and in the subgroup that survived to the end of treatment. A total of 78 patients (30 women, mean age: 61.15±18.5 years) met the inclusion criteria. In the intention to treat analysis group, one-month-mortality was 44.87% (35/78) in the overall cohort. In the end of treatment analysis group, one-month-mortality was 29.5% (18/61) in the overall cohort. Day 7-10 PCR negativity was detected in 55.7% of the overall EOT cohort. Our data suggest that TDF may be an alternative salvage treatment option in antiviral unresponsive patients. We suggest evaluating TDF in well-designed controlled trials involving treatment-naïve cases.

Tenofovir

2019-20 coronavirus outbreak

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ARDS ve Sepsis: Güncel Değerlendirme ve Tedavi

Turkiye Klinikleri Orthopaedics and Traumatology - Special Topics (2012)

Mehmet Uyar

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Prevention of ventilator-associated pneumonia: Use of the care bundle approach