Hsien-Chein Liu

National Tsing Hua University

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Linyi Chen

National Tsing Hua University

Shao-Lun Lo

National Tsing Hua University

F.-Y. Tsai

Chang Gung University

Hsin‐Kai Tseng

National Tsing Hua University

Ali Akbar Moosavi‐Movahedi

University of Tehran

Chun‐Cheng Lin

National Tsing Hua University

Sabbasani Rajasekhara Reddy

Vellore Institute of Technology University

G. H. Hakimelahi

Institute of Chemistry, Academia Sinica

Famil Valiyev

State Oil Company of Azerbaijan Republic (Azerbaijan)

Ali Akbar Saboury

University of Tehran

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National Tsing Hua University

Weatherford College

University of Tehran

Institute of Biochemistry and Biophysics, Polish Academy of Sciences

Academia Sinica

Institute of Chemistry, Academia Sinica

Nanjing Medical University

Kunming Medical University

Peking University

Institute of Molecular Medicine

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Design, synthesis, and antiviral activity of novel phosphoramidates

Journal of the Iranian Chemical Society (2008)

Famil Valiyev F.-Y. Tsai Ali Akbar Saboury Hsien-Chein Liu Ali Akbar Moosavi‐Movahedi

Phosphoramidate

Nucleoside analogue

10.1007/bf03246112

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Citations (3)

Chemoenzymatic Synthesis of GAA-7 Glycan Analogues and Evaluation of Their Neuritogenic Activities

ACS Chemical Neuroscience (2024)

Hsin‐Kai Tseng Yung‐Yu Su Po-Jen Lai Shao-Lun Lo Hsien-Chein Liu

Ganglioside GAA-7 exhibits higher neurite outgrowth than ganglioside GM1a and most echinodermatous gangliosides (EGs) when tested on neuron-like rat adrenal pheochromocytoma (PC12) cells in the presence of nerve growth factor (NGF). The unique structure of GAA-7 glycan, containing an uncommon sialic acid (8-O-methyl-N-glycolylneuraminic acid) and sialic acid-α-2,3-GalNAc linkage, makes it challenging to synthesize. We recently developed a streamlined method to chemoenzymatically synthesize GAA-7 glycan and employed this modular strategy to efficiently prepare a library of GAA-7 glycan analogues incorporating N-modified or 8-methoxyl sialic acids. Most of these synthetic glycans exhibited moderate efficacy in promoting neuronal differentiation of PC12 cells. Among them, the analogue containing common sialic acid shows greater potential than the GAA-7 glycan itself. This result reveals that methoxy modification is not essential for neurite outgrowth. Consequently, the readily available analogue presents a promising model for further biological investigations.

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Ganglioside

10.1021/acschemneuro.3c00732

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Citations (2)