Jiayao Fan

Second Affiliated Hospital of Zhejiang University

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i-10 index

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Dan Zhou

Vanderbilt University Medical Center

Yingjun Li

Hangzhou Medical College

Jiahao Zhu

Hangzhou Medical College

Yuan Zhou

Shanghai Xuhui Central Hospital

Shaofang Cai

Xiamen Medical College

Jin‐Jun Wang

Southwest University

Chunhong Fan

Peking University People's Hospital

Wei Dou

Shanghai Customs College

Lingling Sun

Shandong University of Science and Technology

Yimin Zhu

Zhejiang University

Cooperative Institutions

Zhejiang University

Second Affiliated Hospital of Zhejiang University

Southwest University

Hangzhou Medical College

Chinese Academy of Sciences

Chinese Academy of Medical Sciences & Peking Union Medical College

Fudan University

Central South University

Capital Medical University

Huazhong University of Science and Technology

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Odorant binding protein 2 reduces imidacloprid susceptibility of Diaphorina citri

Pesticide Biochemistry and Physiology (2020)

Xiaoqiang Liu Hong‐Bo Jiang Yi Liu Jiayao Fan Ya-Juan Ma

Diaphorina citri

Abamectin

Neonicotinoid

10.1016/j.pestbp.2020.104642

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Citations (35)

Causal association of adipokines with osteoarthritis: a Mendelian randomization study

Lara D. Veeken (2020)

Jiayao Fan Jiahao Zhu Lingling Sun Yasong Li Tianle Wang

This two-sample Mendelian randomization study aimed to delve into the effects of genetically predicted adipokine levels on OA.Summary statistic data for OA originated from a meta-analysis of a genome-wide association study with an overall 50 508 subjects of European ancestry. Publicly available summary data from four genome-wide association studies were exploited to respectively identify instrumental variables of adiponectin, leptin, resistin, chemerin and retinol-blinding protein 4. Subsequently, Mendelian randomization analyses were conducted with inverse variance weighted (IVW), weighted median and Mendelian randomization-Egger regression. Furthermore, sensitivity analyses were then conducted to assess the robustness of our results.The positive causality between genetically predicted leptin level and risk of total OA was indicated by IVW [odds ratio (OR): 2.40, 95% CI: 1.13-5.09] and weighted median (OR: 2.94, 95% CI: 1.23-6.99). In subgroup analyses, evidence of potential harmful effects of higher level of adiponectin (OR: 1.28, 95% CI: 1.01-1.61 using IVW), leptin (OR: 3.44, 95% CI: 1.18-10.03 using IVW) and resistin (OR: 1.18, 95% CI: 1.03-1.36 using IVW) on risk of knee OA were acquired. However, the mentioned effects on risk of hip OA were not statistically significant. Slight evidence was identified supporting causality of chemerin and retinol-blinding protein 4 for OA. The findings of this study were verified by the results from sensitivity analysis.An association between genetically predicted leptin level and risk of total OA was identified. Furthermore, association of genetically predicted levels of adiponectin, leptin and resistin with risk of knee OA were reported.

Mendelian Randomization

Association (psychology)

Mendelian inheritance

10.1093/rheumatology/keaa719

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Citations (30)

Relationship between Natural Environment and Orthopedic Diseases based on Remote Sensing in Zhejiang Province, China

Polish Journal of Environmental Studies (2022)

Wenyuan Wu Yaoyao Zheng Jiayao Fan Xifen Chen Yiying Qi

The purpose of this study is to investigate the relationship between the natural environment and orthopedic diseases based on remote sensing in Zhejiang Province, China.The Landsat 8 OLI images were employed to extract environmental factors such as the vegetation, water, and urban indices.Combined with the distribution data of patients of different ages diagnosed with different types of orthopedic diseases, derived from the Second Affiliated Hospital, Zhejiang University School of Medicine, we analyzed the spatial distribution relationship and evaluated the natural environmental factors around the distribution sites of the patients.The results showed that the vegetation index (NDVI) is negatively correlated with the prevalence of hospital visits, whereas the water index (MNDWI) is positively correlated.And urban index (IBI) is positively correlated but unstable.The analysis and evaluation of the impact of natural environmental factors related to the patient on orthopedic diseases show that the risk of orthopedic disease might be associated with less vegetation and more water, and are not related to urbanization.And this conclusion is stable in the four seasons.

10.15244/pjoes/149409

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Citations (0)

Genetic Mapping of Serum Metabolome to Chronic Diseases Among Han Chinese

Chunxiao Cheng Fengzhe Xu Xiong‐Fei Pan Cheng Wang Jiayao Fan

Serum metabolites are not just biomarkers but potential regulators for chronic diseases. To gain a better understanding of the genetic regulation of metabolites and their roles in chronic diseases, we quantified 2,759 serum metabolites and performed genome-wide association studies (GWAS) among 3,795 Han Chinese individuals. We identified 245 study-wide significant (P < 1.81×10-11) metabolite quantitative trait loci (metaboQTLs), 55.5% (136) of which were novel. Leveraging the GWAS for 37 clinical traits from East Asians, our Mendelian randomization analyses identified 906 potential causal relationships between metabolites and clinical traits, including 27 for type 2 diabetes and 38 for coronary artery disease. In addition, the putative regulators of several metabolites were revealed by incorporating genetic regulation across the transcriptome and proteome. Particularly, our analyses highlighted the role of lysophosphatidylethanolamine (LPE) in type 2 diabetes and uncovered the putative upstream regulators of LPE, including LIPC and multiple HDL particle-related proteins. In summary, we depict a landscape of the genetic architecture of serum metabolome among Han Chinese and provide insights into the role of serum metabolites in chronic diseases.

Metabolome

10.2139/ssrn.4822913

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Life Education in College English Teaching Reform Life Education in College English Teaching Reform , by Wu Biyu & Mao Feng, London, New Classic Press, 2023, 292 pp., ￡20.99 (paperback), ISBN: 978-1-915865-11-3

Asia Pacific Journal of Education (2023)

Jiayao Fan Biyu Wu

Click to increase image sizeClick to decrease image size Disclosure statementNo potential conflict of interest was reported by the author(s).Notes1. Qingnian Xinlijiankang Laxiang Jingba: Jin Sancheng You Yiyu Fengxian [Youth Mental Health in Danger: Nearly 30 Percent of Young People Are at Risk of Depression].[2023-9-12] http://health.people.com.cn/n1/2019/0411/c14739 −31024064.html.Additional informationNotes on contributorsJiayao FanJiayao Fan, the first author, is a master student in School of English Studies, Shanghai International Studies University, majoring in Translation Studies.Biyu WuBiyu Wu, the corresponding author, is a professor in Xianda College of Economics and Humanities, Shanghai International Studies University, Shanghai, China, with English-Chinese comparison and Translation as the major research field.

College English

10.1080/02188791.2023.2287274

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A Novel Metabolomic Aging Clock Predicting Health Outcomes and Its Genetic and Modifiable Factors

Advanced Science (2024)

Xueqing Jia Jiayao Fan Xucheng Wu Xingqi Cao Lina Ma

Abstract Existing metabolomic clocks exhibit deficiencies in capturing the heterogeneous aging rates among individuals with the same chronological age. Yet, the modifiable and non‐modifiable factors in metabolomic aging have not been systematically studied. Here, a new aging measure—MetaboAgeMort—is developed using metabolomic profiles from 239,291 UK Biobank participants for 10‐year all‐cause mortality prediction. The MetaboAgeMort showed significant associations with all‐cause mortality, cause‐specific mortality, and diverse incident diseases. Adding MetaboAgeMort to a conventional risk factors model improved the predictive ability of 10‐year mortality. A total of 99 modifiable factors across seven categories are identified for MetaboAgeMort. Among these, 16 factors representing pulmonary function, body composition, socioeconomic status, dietary quality, smoking status, alcohol intake, and disease status showed quantitatively stronger associations. The genetic analyses revealed 99 genomic risk loci and 271 genes associated with MetaboAgeMort. The tissue‐enrichment analysis showed significant enrichment in liver. While the external validation of the MetaboAgeMort is required, this study illuminates heterogeneous metabolomic aging across the same age, providing avenues for identifying high‐risk individuals, developing anti‐aging therapies, and personalizing interventions, thus promoting healthy aging and longevity.

10.1002/advs.202406670

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Citations (3)

Mémoire concernant les effets néfastes de l’exposition au bruit chez les travailleurs au Québec

Adel Ramdane Bellal Naomi Constantin Jiayao Fan Maxime Fillion Julie‐Émilie Huot‐Marchand

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Associations of urinary levels of phenols and parabens with osteoarthritis among US adults in NHANES 2005–2014

Ecotoxicology and Environmental Safety (2020)

Yingjun Li Jiahao Zhu Jiayao Fan Shaofang Cai Chunhong Fan

10.1016/j.ecoenv.2020.110293

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Citations (30)

Proteome-wide association study identifies novel Alzheimer's disease- associated proteins

Research Square (Research Square) (2024)

Lingyun Sun Guikang Wei Feiyang Ji Yihong Ding Jiayao Fan

Abstract Background Alzheimer's disease (AD) is a progressive neurodegenerative disease, with a critical shortage of effective prevention and treatment options. Here, we aimed to identify proteins whose genetically regulated plasma levels were associated with AD and its related phenotypes. Methods An integrative proteome-wide search using Olink-based plasma proteomes (N = 45,540) from the UK Biobank Pharma Proteomics Project (UKB-PPP) and a large-scale genome-wide association study (GWAS) for AD (N case = 111,326, N control = 677,663) was employed to identify AD-associated proteins. Cohort studies for AD or mild cognitive disorder (MCD) with average follow-ups of 13.7 years, alongside cross-sectional studies for the volume of whole hippocampus (WH) and white matter hyperintensities (WMH) were performed to provide additional supports. Results We identified 30 AD-associated proteins through a genetic-informed proteome-wide association study (PWAS). Among these, 14 proteins (including TREM2 and GRN) have been previously reported to be associated with AD. No clear evidence has linked the remaining 16 proteins (including PILRB, FES, and HDGF) with AD. PILRB and FES were further supported by cohort studies for AD and/or MCD. A higher plasma abundance of HDGF was found to be associated with a lower volume of whole-hippocampus and an increased risk of AD, consistent with a previous study which showed a potentially risk role of HDGF for AD in both brain tissues and cerebrospinal fluid. The protein-protein interaction analysis linked PILRB with ABCA7, an AD-related protein involved in the immune system. Conclusions The integrative genetic-informed proteome-wide scan provides promising AD-associated proteins for further mechanistic studies.

Proteome

Association (psychology)

10.21203/rs.3.rs-4648743/v1

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Citations (0)

Circulating Chemerin Level and Risk of Cancer: A Systematic Review and Meta-Analysis

Biomarkers in Medicine (2020)

Xiaolong Qi Jiayao Fan Jiahao Zhu Yuxiao Ling Shuai Mi

Aim: Circulating chemerin level has been reported to be higher in patients with various types of cancer. However, the conclusions obtained are not unified. The aim of present study is to draw an evidence-based conclusion on the relationship between circulating chemerin and risk of cancer. Materials & methods: A systematic search was carried out in PubMed and Web of Science up to 30 June 2019. The random-effects model was applied to calculate summary standardized mean differences with 95% CIs. Results: The meta-analysis included a total of 12 separate studies, 876 cases and 739 healthy controls. The results showed that the expression level of circulating chemerin was significantly higher in cancer patients than that in control group (pooled standardized mean difference = 1.47, 95% CI = 1.03–1.90). Conclusion: This meta-analysis concludes that a high level of circulating chemerin is strongly associated with cancer risk.

Chemerin

10.2217/bmm-2019-0500

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Citations (10)