Vasopressin (VP), given intracerebrally to rats, can induce antipyresis, motor disturbances, and increases in arterial blood pressure. The possibility that the VP-binding sites in the fundus striati (FStr) could participate in these effects was investigated. After a bilateral injection of 100 pmol of VP into the FStr, the fever induced by an injection of the lipopolysaccharide of Escherichia coli (50 micrograms/kg ip) was not affected. Bilateral injections of 100 pmol of VP did not induce motor disturbances or alterations in body temperature after either of two successive injections. In contrast, bilateral injections of VP into urethan-anesthetized rats induced dose-dependent increases in arterial pressure without affecting heart rate. This increase was blocked by a V1 antagonist; oxytocin and a V2 agonist were ineffective. In keeping with this preliminary pharmacological analysis, radio-ligand-binding studies of the FStr revealed binding sites in the FStr exhibiting a binding profile typical of the V1 subtype. This study suggests that the V1 receptors in the FStr could participate in the central regulation of the blood pressure.

Fundus (uterus)

10.1152/ajpregu.1995.269.3.r497

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Citations (5)

O2 - Ocytocine et douleur

Douleurs Évaluation - Diagnostic - Traitement (2005)

Marie José Freund‐Mercier

Vitamin K2

10.1016/s1624-5687(05)80311-7

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Citations (0)

Mapping of FosB/DeltaFosB expression in the rat nervous system after hindpaw inflammation

HAL (Le Centre pour la Communication Scientifique Directe) (2006)

Malika Benbouzid Oliva Erendira Luis‐Delgado Pierre Veinante Elisabeth Waltisperger Jean‐Luc Rodeau

FOSB

Expression (computer science)

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Autoradiographic demonstration of oxytocin-binding sites in the macula densa

AJP Renal Physiology (1989)

M.E. Stoeckel Marie José Freund‐Mercier

Specific oxytocin (OT)-binding sites were localized in the rat kidney with use of a selective 125I-labeled OT antagonist (125I-OTA). High concentrations of OT binding sites were detected on the juxtaglomerular apparatus with use of the conventional film autoradiographic technique. No labeling occurred on other renal structures. The cellular localization of the OT binding sites within the juxtaglomerular apparatus was studied in light microscope autoradiography, on semithin sections from paraformaldehyde-fixed kidney slices incubated in the presence of 125I-OTA. These preparations revealed selective labeling of the macula densa, mainly concentrated at the basal pole of the cells. Control experiments showed first that 125I-OTA binding characteristics were not noticeably altered by prior paraformaldehyde fixation of the kidneys and second that autoradiographic detection of the binding sites was not impaired by histological treatments following binding procedures. In view of the role of the macula densa in the tubuloglomerular feedback, the putative OT receptors of this structure might mediate the stimulatory effect of OT on glomerular filtration.

Macula densa

Tubuloglomerular feedback

Paraformaldehyde

Juxtaglomerular apparatus

Oxytocin receptor

10.1152/ajprenal.1989.257.2.f310

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Citations (45)

Mechanism of oxytocin antinociception in spinal pain pathways

HAL (Le Centre pour la Communication Scientifique Directe) (2006)

Marie José Freund‐Mercier Jean‐Didier Breton Gerardo Rojas-Piloni Mónica Lopez-Hidalgo Guadalupe Martı́nez-Lorenzana

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