Y.u-Shien Ko

Chang Gung Memorial Hospital

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Lung‐An Hsu

Chang Gung Memorial Hospital

Yu-Shien Ko

Chang Gung Memorial Hospital

Tzung-Yan Lee

Chang Gung University

Lai‐Chu See

Chang Gung University

Chi-Tai Kou

Chang Gung Memorial Hospital

Chi‐Jen Chang

Chang Gung Memorial Hospital

Po‐Yu Huang

Chi Mei Medical Center

Jong‐Hwei S. Pang

Chang Gung Memorial Hospital

Michael F. Chiang

National Institutes of Health

Ying‐Shiung Lee

University of Medical Sciences and Technology

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Chang Gung Memorial Hospital

Chang Gung University

Linkou Chang Gung Memorial Hospital

Memorial Hospital of South Bend

Kaohsiung Chang Gung Memorial Hospital

National Yang Ming Chiao Tung University

Institute of Cardiology

Taoyuan Chang Gung Memorial Hospital

Chung Shan Medical University

Keelung Chang Gung Memorial Hospital

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Percutaneous transvenous mitral valvulotomy normalizes elevated circulating levels of tumor necrosis factor-α and interleukin-6 in mitral stenosis with heart failure

The American Journal of Cardiology (2003)

Chi‐Jen Chang Lung‐An Hsu Michael F. Chiang Y.u-Shien Ko Lai‐Chu See

Mitral valve stenosis

10.1016/s0002-9149(03)00131-0

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Citations (13)

Electroacupuncture relieves portal hypertension by improving vascular angiogenesis and linking gut microbiota in bile duct ligation rats

Frontiers in Microbiology (2023)

Po‐Yu Huang Hsuan-Miao Liu Y.u-Shien Ko Zi‐Yu Chang Tzung-Yan Lee

The pathological increase in the intrahepatic resistance and decrease peripheral vascular tone in the development of portal hypertension (PHT). PHT has been linked to lower microbial diversity and weakened intestinal barrier, and interplay alters inflammatory signaling cascades. Electroacupuncture (EA) may ameliorate the inflammatory response and limit arterial vasodilatation and portal pressure. This study addresses the possible mechanisms underlying putative hemodynamics effects of EA in PHT rats. PHT was induced by bile duct ligation (BDL) over 7 days in rats. BDL rats were treated with low-frequency EA (2 Hz) at acupoint, ST36, 10 min once daily for 7 consecutive days. EA significantly reduced portal pressure and enhanced maximum contractile responses in the aorta, and blunts the angiogenesis cascade in PHT rats. EA decreased the aortic angiogenesis signaling cascade, reflected by downregulated of ICAM1, VCAM1, VEGFR1, and TGFβR2 levels. In addition, EA preserved claudin-1, occludin, and ZO-1 levels in BDL-induced PHT model. Furthermore, EA demonstrates to have a positive effect on the gut Bacteroidetes / Firmicutes ratio and to reduce pro-inflammatory cytokines and endotoxins. These results summarize the potential role of EA in the gut microbiota could potentially lead to attenuate intestine injury which could further contribute to vascular reactivity in PHT rats.

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10.3389/fmicb.2023.1207137

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Citations (1)