Jayanti Shastri

Kasturba Hospital

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Sachee Agrawal

Topiwala National Medical College & BYL Nair Charitable Hospital

Sujata Baweja

Lokmanya Tilak Municipal General Hospital and Lokmanya Tilak Municipal Medical College

Michelle Fonseca

Lokmanya Tilak Municipal General Hospital and Lokmanya Tilak Municipal Medical College

Gajanan Velhal

College of Medicine & JNM Hospital

Shahina Begum

National Institute for Research in Reproductive Health

Sarah Cherian

Case Western Reserve University

Varsha Potdar

ICMR-National Institute of Virology

Sanjay Chauhan

Gujarat Technological University

Dilip Turbadkar

Lokmanya Tilak Municipal General Hospital and Lokmanya Tilak Municipal Medical College

Pragya D. Yadav

ICMR-National Institute of Virology

Cooperative Institutions

Indian Council of Medical Research

Indian Institute of Technology Bombay

ICMR-National Institute of Virology

National Institute for Research in Reproductive Health

Government of India

All India Institute of Medical Sciences

Ministry of Health and Family Welfare

Lokmanya Tilak Municipal General Hospital and Lokmanya Tilak Municipal Medical College

Department of Health Research

Christian Medical College & Hospital

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Seroprevalence of HBV and HCV in Forensic Autopsy Cases

Medico-Legal Update (2014)

Seema Khambatta Neha Sinha Pawan Sabale Jayanti Shastri Shailesh Mohite

Autopsy rooms are known to be high risk areas for infection and pose a potential health hazard for those working there. While conducting autopsies in conditions which may not provide adequate protection to the forensic personnel, it exposes them to high risk blood-borne viral and other bacterial infections. With the increasing seroprevalence of hepatitis virus, the mutilated and traumatized bodies of victims requiring autopsy, pose a considerable risk to the forensic personnel handling these remains. However limited data are available regarding the risk of acquiring such infections.

Seroprevalence

Forensic Pathology

Hepatitis C

10.5958/0974-1283.2014.00742.7

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Citations (1)

Contraceptive use and unintended pregnancies among HIV-infected women in Mumbai

Indian Journal of Community Medicine (2015)

Beena Joshi Gajanan Velhal Sanjay Chauhan Ragini Kulkarni Shahina Begum

Access to reproductive health services in Human Immunodeficiency Virus (HIV) programs can greatly enhance program's potential to limit the spread of disease, reduce unintended pregnancies and safeguard the health of infected people.To assess (i) knowledge, attitude, and use regarding contraceptives; safe sex and dual protection; (ii) fertility desires and unintended pregnancies post HIV and (iii) symptoms of reproductive tract infection/sexually transmitted infection (RTI/STI) among women infected with HIV.A cross-sectional study among 300 currently married HIV-positive women who had not undergone permanent sterilization with no immediate desire for pregnancy. Study site was Integrated Counseling and Testing Centers (ICTC) in tertiary hospitals of Mumbai and women were interviewed using a semistructured questionnaire.In spite of good awareness about modern methods, 42.7 felt that contraceptives other than condoms were harmful to use due to their HIV status. Knowledge on dual protection was limited to condom (75%). Condom use increased from 5.7% pre-HIV to 71.7% post-HIV, with 89.6% reporting regular use. Future fertility desire was expressed by 8.7% women. Induced abortions post-HIV was reported by16.6% women, as pregnancies were unintended. About 69% wished to use dual contraceptive methods for effective protection if it was not harmful to be used by people living with HIV (PLHIV).Data reveals a need to promote modern contraceptive methods along with regular condom use to prevent unintended pregnancies and improve health-seeking behavior for contraception. Health system models that converge or link HIV services with other reproductive health services need to be tested to provide comprehensive reproductive healthcare to infected women in India.

Unintended Pregnancy

Sterilization

10.4103/0970-0218.158855

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Citations (18)

Detection of the omicron variant in international travellers and their family contacts in India

medRxiv (Cold Spring Harbor Laboratory) (2021)

Varsha Potdar Pragya D. Yadav Kavita S. Lole Sarah Cherian Jayanti Shastri

Highlights With the emergence of the Variant of Concern, omicron (B.1.1.529), India has enhanced genomic surveillance in international travellers. The omicron variant was detected in 59 cases from different States; 40 from Maharashtra, 17 from Rajasthan and one each from Gujrat and Tamil Nadu. The positive cases and their contacts were asymptomatic and genomic surveillance could identify two clusters, one from Maharashtra and another from Rajasthan.

Tamil

10.1101/2021.12.27.21268429

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An Epidemiological Analysis of SARS-CoV-2 Genomic Sequences from Different Regions of India

Viruses (2021)

Pragya D. Yadav Dimpal A. Nyayanit Triparna Majumdar Savita Patil Harmanmeet Kaur

The number of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) cases is increasing in India. This study looks upon the geographic distribution of the virus clades and variants circulating in different parts of India between January and August 2020. The NPS/OPS from representative positive cases from different states and union territories in India were collected every month through the VRDLs in the country and analyzed using next-generation sequencing. Epidemiological analysis of the 689 SARS-CoV-2 clinical samples revealed GH and GR to be the predominant clades circulating in different states in India. The northern part of India largely reported the 'GH' clade, whereas the southern part reported the 'GR', with a few exceptions. These sequences also revealed the presence of single independent mutations-E484Q and N440K-from Maharashtra (first observed in March 2020) and Southern Indian States (first observed in May 2020), respectively. Furthermore, this study indicates that the SARS-CoV-2 variant (VOC, VUI, variant of high consequence and double mutant) was not observed during the early phase of virus transmission (January-August). This increased number of variations observed within a short timeframe across the globe suggests virus evolution, which can be a step towards enhanced host adaptation.

Molecular Epidemiology

10.3390/v13050925

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Citations (41)

Biopolymer Coating Imparts Sustainable Self-Disinfecting and Antimicrobial Properties to Fabric: Translated to Protective Gears for the Pandemic and Beyond

ACS Biomaterials Science & Engineering (2023)

Kapil Punjabi Eshant Bhatia Roshan Keshari Kiran Jadhav Subhasini Singh

The global pandemic of COVID-19 and emerging antimicrobial drug resistance highlights the need for sustainable technology that enables more preparedness and active control measures. It is thus important to have a reliable solution to avert the present situations as well as preserve nature for habitable life in the future. One time use of PPE kits is promoting the accumulation of nondegradable waste, which may pose an unforeseen challenge in the future. We have developed a biocompatible, biodegradable, and nonirritating nanoemulsion coating for textiles. The study focused on coating cotton fabric to functionalize it with broad spectrum antimicrobial, antibiofilm, and anti-SARS-CoV-2 activity. The nanoemulsion comprises spherical particles of chitosan, oleic acid, and eugenol that are cross-linked to fibers. The nanoemulsion caused complete destruction of pathogens even for the most rigid biofilms formed by drug resistant Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans on the surface of the coated fabric. The secondary coat with beeswax imparts super hydrophobicity and 20 wash cycle resistance and leads to enhanced barrier properties with superior particulate filtration, bacterial filtration, and viral penetration efficiency as compared to an N95 respirator. The coated fabric qualifies as per standard parameters like breathability, flammability, splash resistance, and filtration efficiency for submicrometer particles, bacteria, and viruses. The scaleup and bulk manufacturing of the coating technology on fabric masks complied with standards. The consumer feedback rated the coated mask with high scores in breathability and comfortability as compared to an N95. The strategy promises to provide a long-term sustainable model compared to single use masks and PPE that will remain a nondegradable burden on the ecosystem for years to come.

Biopolymer

10.1021/acsbiomaterials.2c01481

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Citations (6)

Improving dual protection among women infected with HIV

BMC Infectious Diseases (2014)

Beena Joshi Gajanan Velhal Sanjay Chauhan Ragini Kulkarni Shahina Begum

Background The PPTCT program in India focuses on prong 3 (Provision of Nevirapine to pregnant infected mothers) and reports quote that it reaches only 32% of pregnant mothers who need it. Preventing unintended pregnancies among HIV positive women (Prong 2) could help reduce the burden on Prong 3. To improve use of dual protection and prevent unintended pregnancies among women infected with HIV, an operational research study was implemented in two randomly selected tertiary hospitals in Mumbai (supported by ICMR).

Nevirapine

Medical microbiology

10.1186/1471-2334-14-s3-e40

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Citations (2)

Proteomic Investigation Reveals Dominant Alterations of Neutrophil Degranulation and mRNA Translation Pathways in COVID-19 Patients.

iScience (2021)

Renuka Bankar Kruthi Suvarna Saicharan Ghantasala Arghya Banerjee Deeptarup Biswas

Proteome

10.17632/rnfn3vhg63.1

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Citations (1)

MEASUREMENT OF HBsAg IN RENAL-UNIT PATIENTS

The Lancet (1979)

Thomas John Jayanti Shastri

10.1016/s0140-6736(79)91408-9

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Evaluation of Extravesical and Leadbetter‐Politano Ureteroneocystostomy in Renal Transplantation

British Journal of Urology (1988)

Sudeep R. Shah Vijay Nath Ganesh Gopalkrishnan Abhishek Pandey Jayanti Shastri

Summary— In a series of 650 renal transplantations performed over a 4‐year period, the results were evaluated of 125 Leadbetter‐Politano and 125 extravesical ureteroneocystostomies. The Leadbetter‐Politano technique had a complication rate of 4%, with 3.2% of these patients having a vesical leak. Extravesical ureteroneocystostomy also had a 4% complication rate but only 1.6% of these patients had a vesical leak. Although there was no statistical difference between the two groups with regard to complications, we feel that extravesical ureteroneocystostomy is a quick and simple procedure and well suited to the special challenge presented by renal transplant recipients.

Ureterostomy

10.1111/j.1464-410x.1988.tb04386.x

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Citations (27)