Shujuan Jin

Chinese PLA General Hospital

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Mirosław J. Tomaszewski

AstraZeneca (United Kingdom)

Gérald Bernardinelli

University of Geneva

Bin Xia

Peking University

Haobin Song

Changzhou University

Christopher Walpole

AstraZeneca (Canada)

Charles W. Jefford

University of Geneva

Hanna Tukachinsky

Foundation Medicine (United States)

Haofei Luan

PharmacoGenetics (China)

Zhenjie Ma

Changchun Institute of Technology

Shao‐Liang Zheng

Harvard University

Cooperative Institutions

Chinese Academy of Sciences

AstraZeneca (Canada)

AstraZeneca (United Kingdom)

Academy of Military Medical Sciences

AstraZeneca (Brazil)

Sun Yat-sen University

Peking University

Chinese PLA General Hospital

Harvard University

Shanghai Jiao Tong University

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ChemInform Abstract: Synthesis of 3‐Aryl Substituted Benzo[1,2,5]triazepin‐4‐ones via Intramolecular Imine Formation.

ChemInform (2009)

Mirosław J. Tomaszewski Luc Boisvert Shujuan Jin

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Imine

10.1002/chin.200927165

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LBCS: A Load Balanced Clustering Scheme in Wireless Sensor Networks

Shujuan Jin Keqiu Li

In a wireless sensor network, the randomly and widely deployed sensors are powered by battery, which is impossible to get recharged after deployment. Thus, energy efficiency of the sensor nodes is an important issue in wireless sensor networks for guaranteeing the network's lifetime. Clustering is one of the most popular and effective topologies in wireless sensor networks as it reduces the whole network's energy consumption. In this paper, we propose a load balanced clustering scheme, which distributes the cluster head nodes' heavy burden to other assistant nodes, and takes multi-hop scheme to transmit the aggregated data to the base station. Furthermore, in the cluster formation phase, we select the cluster node by combining the distance factor and the residual energy factor. As a result, this clustering scheme balances the whole network's energy consumption, and prolongs the network's lifetime. At last, we conduct some simulations in NS-2, and the results show that the proposed scheme prolongs the network lifetime longer than LEACH and EECS do.

10.1109/mue.2009.47

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Citations (19)

CCDC 677004: Experimental Crystal Structure Determination

The Cambridge Structural Database (2009)

M.J. Tomaszewski Luc Boisvert Shujuan Jin

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/ccqqgvq

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Variations in early gut microbiome are associated with childhood eczema

FEMS Microbiology Letters (2019)

Yu Zhang Shujuan Jin Jingjing Wang Lanying Zhang Yu Mu

We assessed the relationship between gut microbiome profile and childhood eczema in 172 subjects (age < 3 years, healthy group N = 123, eczema group N = 49) utilizing 16S rRNA gene sequencing. Lower relative abundance of Bifidobacterium was shown to be associated with childhood eczema. Considering that developmental and environmental factors could modify the state of children's gut microbiome, we divided the samples into four age groups: 0-0.5 years, 0.5-1 years, 1-2 years and 2-3 years for farther analyses. Data revealed significant inter-group differences between healthy and eczema samples in all age groups, and decreased microbial diversity was most significantly found in children with eczema of age 2-3 years old. Decreased abundance of Bifidobacterium was a major finding in eczema groups from 0.5-3 years compared to the age matched healthy controls, but not significant in children younger than 6 month old. Of note, Bifidobacterium operational taxonomic units were identified by Random Forest with highly predictive power of 0.83 (AUC = 0.83) in ROC analysis, which also confirmed its role as a key genus that is associated with eczema. To verify the sequencing results, we performed quantitative polymerase chain reaction of Bifidobacterium and Bacteroides in the same cohort, and in a new eczema cohort (N = 57) for validation. Significantly, lower Bifidobacterium quantities were found in both eczema groups with an age range of 0.5-3 years. These results suggest variations in early gut microbiome are associated with childhood eczema.

10.1093/femsle/fnz020

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Citations (14)

Reductive cleavage of resin bound arylsulfonates

Tetrahedron Letters (1998)

Shujuan Jin David P. Holub David J. Wustrow

Cleavage (geology)

Carboxylate

Bond cleavage

10.1016/s0040-4039(98)00640-6

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Citations (29)

Argonaute proteins: structures and their endonuclease activity

Molecular Biology Reports (2021)

Shujuan Jin Jian Zhan Yaoqi Zhou

Argonaute

RasiRNA

Piwi-interacting RNA

RNA-induced silencing complex

Trans-acting siRNA

RNA Silencing

10.1007/s11033-021-06476-w

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Citations (31)

Core needle biopsy for molecular classification of breast cancer

Zhonghua putong waike zazhi (2017)

Sheng Chen Ye Wang Weiwei Liu Huaitao Wang Shujuan Jin

Objective To evaluate core needle biopsy (CNB) in detecting estrogen receptor (ER) and progesterone receptor (PR) of HER2, Ki67, and molecular classification of breast cancer. Methods Clinical data of 188 breast cancer patients admitted from Nov 2012 to Jun 2015, were retrospectively analyzed. All patients received both CNB and open excision biopsy (OEB). Immunohistochemistry (IHC) was used to evaluate the expression of ER, PR, HER2 and Ki67. All cases were categorized into four molecular subtypes: Luminal A, Luminal B, triple negative breast cancer and HER2 over-expression breast cancer. Kappa test was used to evaluate the consistency of CNB and OEB. Results Concordance rate of ER, PR, HER2 receptor status and Ki67 value were 94.68%, 93.62%, 94.68% and 73.40%. There was no difference between CNB and OEB for non- Luminal tumors (P=0.774). Ki67 expression in OEB samples was higher than in CNB samples (25.90% vs. 21.65%, P<0.001). Concordance rate between CNB and OEB for molecular subtypes was 72.34% (K=0.606 4). Conclusions CNB is accurate in evaluating ER, PR, HER2 and Ki67 in breast cancer. CNB is accurate in diagnosing non-Luminal molecular subtypes of breast cancer. Key words: Breast neoplasms; Biopsy, needle; Molecular typing; Ki-67 antigen

Concordance

Progesterone receptor

Kappa

Triple-negative breast cancer

10.3760/cma.j.issn.1007-631x.2017.01.016

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Zn(II) can mediate self-association of the extracellular C-terminal domain of CD147

Protein & Cell (2017)

Shujuan Jin Pengfei Ding Pengxiang Chu Hongwei Li Jianbo Sun

Human genetics

Association (psychology)

Developmental Biology

10.1007/s13238-017-0443-1

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Potent Uncompetitive Inhibitors of Nicotinamide N-Methyltransferase (NNMT) as In Vivo Chemical Probes

Journal of Medicinal Chemistry (2022)

Robert D. Barrows Daniel E. Jeffries Mahesh Vishe Hanna Tukachinsky Shao‐Liang Zheng

NNMT uses SAM as a cofactor to catalyze the methylation of nicotinamide, producing 1-methylnicotinamide. Recent studies have shown that NNMT upregulation in cancer-associated fibroblasts (CAFs) is required to maintain the CAF phenotype in high-grade serous carcinoma. These observations suggest that NNMT should be evaluated as a therapeutic target, especially in cancer. Although several small-molecule inhibitors of NNMT have been identified, there remains a need for highly potent and selective inhibitors with excellent in vivo activity and ADME properties that can be used as reliable chemical probes. We have identified azaindoline carboxamide 38 as a selective and potent NNMT inhibitor with favorable PK/PD and safety profiles as well as excellent oral bioavailability and pharmaceutical properties. Our mechanistic studies indicate that 38 binds uncompetitively with SAM but competitively with nicotinamide consistent with its binding in the nicotinamide binding site and likely forming a positive interaction with SAM.

ADME

10.1021/acs.jmedchem.2c01166

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Citations (8)

CCDC 2180582: Experimental Crystal Structure Determination

The Cambridge Structural Database (2022)

Robert D. Barrows Daniel E. Jeffries Mahesh Vishe Hanna Tukachinsky Shao‐Liang Zheng

10.5517/ccdc.csd.cc2c62c1

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