Sandra Pietri

Sirris

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Sabrina Ena

Shanghai Cell Therapy Research Institute

Enrico Bastianelli

Bone Therapeutics

E. Chereul

Centre d'Exploration et de Recherche Médicale par Emission de Positons

Olivier Beuf

Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé

F. Taborik

Helene Dubout

Bone Therapeutics

Hugues Contamin

University of Kentucky

A.‐L. Perrier

Laboratoire Optimisation de la Conception et Ingénierie de l'Environnement

Denis Grenier

Chimie et Biologie des Membranes et des Nanoobjects

Candice Hoste

Ghent University

Cooperative Institutions

Université Libre de Bruxelles

Université Claude Bernard Lyon 1

Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé

Centre National de la Recherche Scientifique

Inserm

Bone Therapeutics

UCLouvain

University of Liège

Walloon Excellence in Lifesciences and Biotechnology

Chimie et Biologie des Membranes et des Nanoobjects

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Morphological assessment of non-human primate models of osteoarthritis: Comparisons of HR-MRI with CT arthrography (CTA)

HAL (Le Centre pour la Communication Scientifique Directe) (2012)

A.‐L. Perrier E. Chereul D. Grenier F. Taborik M. Abdallah

Non human primate

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Cell therapy for bone fracture repair: A comparative preclinical review of mesenchymal stromal cells from bone marrow and from adipose tissue

JOURNAL OF MEDICINES DEVELOPMENT SCIENCES (2017)

Sabrina Ena Julia Ino Aurelie Neirinck Sandra Pietri Anna Tury

Over the last decade, there has been an increasing interest among researchers for human mesenchymal stromal cells (MSC). Their regenerative properties, multilineage differentiation capacity and immunomodulatory properties make them promising candidates for treatment in various conditions. Emerging biotechnology companies specialized in cellular and regenerative therapies have been focusing their interest on MSC-based therapies, and their use in clinical trials has steadily increased. Notably, MSC are currently tested in clinical trials addressing unmet medical needs in the field of bone fracture repair and more specifically in non-union and delayed union fractures where the bone repair process is impaired. Although MSC can be isolated from various tissues, the most commonly studied sources are bone marrow (BM) and adipose tissue (Ad). In this article, we reviewed the literature directly comparing BM- and Ad-MSC for their in vitro characteristics and in vivo osteogenic potential to determine which source of MSC would be more appropriate for bone fracture repair. As considerable variations in experimental settings between studies were found, our review was based on studies meeting specific sets of criteria, notably regarding donors’ age and gender. This review of side-by-side comparisons suggests that while BM-and Ad-MSC share common general characteristics, BM-MSC have a higher intrinsic osteogenic capacity in vitro and bone repair potential in vivo.

10.18063/jmds.v1i2.135

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NASAFYTOL® supplementation in adults hospitalized with COVID-19 infection: results from an exploratory open-label randomized controlled trial

Frontiers in Nutrition (2023)

J. Gérain Mélanie Uebelhoer B. Costes Julie Herman Sandra Pietri

Objectives The effect and safety of Nasafytol ® , a food supplement combining curcumin, quercetin, and Vitamin D, on hospitalized COVID-19-positive patients as support to standard of care were to be assessed. Methods This exploratory, open-label, randomized, controlled trial was carried out among hospitalized adults with COVID-19 infection. Participants were randomly assigned to receive Nasafytol ® or Fultium ® control. The improvement of the clinical condition and occurrence of (serious) adverse events were evaluated. The study was registered on clincaltrials.gov with the identifier NCT04844658. Results Twenty-five patients received Nasafytol ® , and 24 received Fultium ® . Demographic characteristics were well balanced between the groups. On day 14 (or at hospital leave if < 14 days), no difference was observed between groups regarding their clinical condition, fever, or the need of oxygen therapy. At day 7, however, 19 participants had been discharged from the hospital in the Nasafytol ® arm compared to 10 participants in the Fultium ® arm. No participants were transferred to the ICU or died in the Nasafytol ® arm, vs. 4 transfers and 1 death in the Fultium ® arm. The clinical condition of participants in the Nasafytol ® arm had improved, as evidenced by a decrease in the COVID-19 WHO score. Interestingly, five SAEs occurred with Fultium ® , while no SAE was observed with Nasafytol ® . Conclusion Supplementation with Nasafytol ® , in addition to standard-of-care treatment, led to a faster discharge from the hospital, improved clinical conditions of participants, and a reduced risk of serious outcomes, including transfer to the intensive care unit or death, in patients hospitalized with COVID-19.

10.3389/fnut.2023.1137407

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Osteogenic superiority of bone marrow-derived osteoblastic cells (ALLOB(R)) over bone marrow-derived mesenchymal stromal cells

Bone Abstracts (2016)

Sandra Pietri Helene Dubout Sabrina Ena Candice Hoste Enrico Bastianelli

Searchable abstracts of presentations at key conferences on calcified tissues ISSN 2052-1219 (online)

10.1530/boneabs.5.p159

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Cell therapy for bone fracture repair: A comparative preclinical review of mesenchymal stromal cells from bone marrow and from adipose tissue

JOURNAL OF MEDICINES DEVELOPMENT SCIENCES (2015)

Sabrina Ena Julia Ino Aurelie Neirinck Sandra Pietri Anna Tury

10.18063/jmds.2015.02.004

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Etude de l'expression du gène EphA7 et de son ligand ephrine-A5 dans le cortex en développement

Sandra Pietri Pierre Vanderhaeghen

Le cortex cerebral constitue l’une des structures les plus evoluees et complexes de notre cerveau. Sa surface est divisee en de nombreuses aires fonctionnelles. La mise en place des aires corticales depend a la fois de facteurs intrinseques comme la secretion de morphogenes ou l’expression en gradient de differents facteurs de transcription, mais elle depend aussi de facteurs extrinseques au cortex, en particulier l'innervation par le thalamus. Les ephrines et leurs recepteurs Eph constituent une famille multigenique de facteurs de signalisation impliques dans divers evenements cle du developpement cortical ou ils sont exprimes selon des profils spatio-temporels complexes. Aux stades tardifs du developpement, EphA7 et l’ephrine-A5 sont exprimes en gradients complementaires au sein de chaque territoire des aires presomptives, constituant ainsi les marqueurs les plus precoces de ces aires corticales. Par la combinaison d’approches in-vitro utilisant la technique d’electroporation focale de tranches corticales embryonnaires, puis in-vivo en utilisant la technique de transgenese d’addition, nous avons identifie une sequence regulatrice de EphA7 appelee pA7, capable de mimer l’expression endogene de EphA7 au sein du telencephale dorsal en developpement. La lignee de souris pA7-GFP ainsi generee exprime la GFP specifiquement au sein du telencephale dorsal durant les stades precoces. Aux stades perinataux cette expression se regionalise au sein de la plaque corticale de chacune des aires presomptives selon des gradients recapitulant ceux observes pour EphA7. Nous avons ensuite purifie des neurones exprimant differents niveaux d’EphA7 par la technique de FACS «Fluorescence-Activated Cell Sorting » et l’analyse de leur transcriptome nous a permis de trouver un grand nombre de genes differentiellement exprimes. Tous ceux testes par la technique d’hybridation in situ sont exprimes selon un gradient lateral fort et medial faible dans le cortex parietal, similaire a celui d’EphA7. L’examination de leur profil au sein de cortex de souris depourvus d’afferences thalamiques, nous a permis de conclure que l’expression de ces genes incluant EphA7 s’etablit independamment de celles-ci. Ainsi, notre etude a permis d'identifier un repertoire de genes neuronaux, pouvant agir en amont ou en combinaison avec EphA7 pour controler les facteurs intrinseques essentiels a l’etablissement des aires corticales./The cerebral cortex is subdivided into distinct cortical areas characterized by specific patterns of gene expression and neuronal connectivity. The patterning of cortical areas is thought to be controlled by a combination of intrinsic factors that are expressed in the cortex, and external signals such as inputs from the thalamus. EphA7 is a member of the ephrin/Eph family of guidance factors that is involved in key aspects of the development of the cortex, and is expressed in several gradients within developing cortical areas. By combining in vitro transcriptional assays and mouse transgenics, we identified a regulatory element of the EphA7 promoter, named pA7, that can recapitulate salient features of the pattern of expression of EphA7 in the developing forebrain, including gradients in the cortex. Using a mouse reporter line where GFP expression recapitulates EphA7 expression, we developed a GFP-based cell sorting procedure to isolate cortical neuron populations displaying different levels of EphA7 expression. Transcriptome analysis of these populations enabled to identify a specific array of differentially expressed genes. All genes validated further in vivo were confirmed to be expressed along distinct gradients in the developing cortical plate, similarly to EphA7. The expression of these genes was unchanged in mutant mice defective for thalamocortical projections, indicating that their graded pattern is largely intrinsic to the cortex. Our study identifies a novel repertoire of cortical neuron genes that may act upstream of, or together with EphA7, to control the intrinsic patterning of cortical areas.

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Superiority of Bone Marrow Derived-Osteoblastic Cells (ALLOB®) over Bone Marrow Derived-Mesenchymal Stem Cells

World Academy of Science, Engineering and Technology, International Journal of Medical and Health Sciences (2016)

Sandra Pietri Helene Dubout Sabrina Ena Candice Hoste Enrico Bastianelli

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Transcriptional Mechanisms of EphA7 Gene Expression in the Developing Cerebral Cortex

Cerebral Cortex (2011)

Sandra Pietri Jordane Dimidschstein Luca Tiberi Panagiota A. Sotiropoulou Angéline Bilheu

The patterning of cortical areas is controlled by a combination of intrinsic factors that are expressed in the cortex and external signals such as inputs from the thalamus. EphA7 is a guidance receptor that is involved in key aspects of cortical development and is expressed in gradients within developing cortical areas. Here, we identified a regulatory element of the EphA7 promoter, named pA7, that can recapitulate salient features of the pattern of expression of EphA7, including cortical gradients. Using a pA7-Green fluorescent Protein (GFP) mouse reporter line, we isolated cortical neuron populations displaying different levels of EphA7/GFP expression. Transcriptome analysis of these populations enabled to identify many differentially expressed genes, including 26 transcription factors with putative binding sites in the pA7 element. Among these, Pbx1 was found to bind directly to the EphA7 promoter in the developing cortex. All genes validated further were confirmed to be expressed differentially in the developing cortex, similarly to EphA7. Their expression was unchanged in mutant mice defective for thalamocortical projections, indicating a transcriptional control largely intrinsic to the cortex. Our study identifies a novel repertoire of cortical neuron genes that may act upstream of, or together with EphA7, to control the patterning of cortical areas.

10.1093/cercor/bhr245

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Comparison of HR-MRI with µCT arthrography for the morphological assessment of non-human primate models of osteoarthritis

HAL (Le Centre pour la Communication Scientifique Directe) (2012)

A.‐L. Perrier E. Chereul Denis Grenier F. Taborik M. Abdallah

Non human primate

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Morphological assessment of non-human primate models of osteoarthritis using HR-MRI and µCT arthrography

HAL (Le Centre pour la Communication Scientifique Directe) (2013)

E. Chereul Denis Grenier Anne‐Laure Perrier F. Taborik Laurent Mahieu-Williame

Non human primate

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