This paper studies the regeneration design of old factory buildings with low production and high consumption which are eliminated under the trend of domestic industrial upgrading, takes the transformation research of old factory buildings under the background of cultural and creative industries as the starting point, combines the relevant information, analyzes the relevant theoretical data on the regeneration design of the old factory buildings concerning the functions, layout, facilities and regeneration forms, etc., and puts forward an optimization strategy suitable for the current trend of regeneration of the old factory buildings based on existing transformation design of the old factory buildings. Regeneration trend optimization strategy. This paper takes Zhaoqing Shuguang Electromechanical Factory as a transformation case, based on adapting to the background of cultural and creative, combining with the demand characteristics of the old factory building transformation, making the optimization design strategy of the old factory building, researching the new scheme suitable for the regeneration design of the old factory building, and solving the problem of the reuse of the old factory building.
Introduction and Methods Silencing gene activation can effectively enrich the diversity of fungal secondary metabolites. Results and Discussion Cultivation of the Yellow River wetland-derived fungus Talaromyces funiculosus HPU-Y01 with aniline led to the isolation of one new aniline-containing polyketide tanicutone A ( 1 ), two new bicyclic polyketides tanicutones B-C ( 2 – 3 ), a new related trienoic acid 8-methyldeca-2,4,6-trienoic acid ( 5 ), and a known compound 4 . The planar structures and configurations of 1 – 5 were determined by NMR, MS, and ECD calculations. Compound 2 featured a key aldehyde group and showed promising inhibitory activity against Vibrio parahaemolyticus with a minimum inhibitory concentration (MIC) value of 0.17 μg/mL. This is a rare report of aniline-induced fungal production of tetrahydronaphthone polyketides.
Seven tetralone derivatives (1–7) were isolated from the deep-sea derived fungus Cladosporium cladosporioides. Compounds 1 and 2 possessed a new dimeric forms of the skeleton, and the new compound 4 was cytotoxic.
Two new nitrogen-containing sorbicillinoids named sorbicillasins A and B (1 and 2) and a new 3,4,6-trisubstituted α-pyrone derivative, scirpyrone K (3), together with two known biosynthetically related polyketides (4⁻5), were isolated from the deep-sea-derived fungus Phialocephala sp. FL30r by using the OSMAC (one strain-many compounds) method. The structures of 1⁻3, including absolute configurations, were deduced based on MS, NMR, and time-dependent density functional theory (TD-DFT) calculations of specific ECD (electronic circular dichroism) spectra. Compounds 1 and 2 possessed a novel hexahydropyrimido[2,1-a] isoindole moiety, and compound 3 exhibited weak radical scavenging activity against DPPH (2,2-diphenyl-1-picrylhydrazyl) with an IC50 value of 27.9 μM.
The acyl-homoserine lactones (AHLs)-mediated LuxI/LuxR quorum sensing (QS) system orchestrates diverse bacterial behaviors in response to changes in population density. The role of the BjaI/BjaR
Precursor-directed biosynthesis was used to introduce selected aniline derivatives into the talaroenamine pathway, which had recently been defined from a Yellow River wetland-derived Penicillim malacosphaerulum HPU-J01. The known talaroenamine B (1) and six previously undescribed talaroenamine derivatives, talaroenamines F–K (2–7), were generated and structurally characterized. The aniline derivatives are introduced via nonenzymatic addition to the reactive intermediate cyclohexanedione. Compound 2 was active against Bacillus cereus with an MIC value of 0.85 μg/mL.
Seven new 6-methylsaligenin derivatives, including the trimeric peniphenylanes A–B (1–2) and dimeric peniphenylanes C–G (3–7), together with four known biogenetically related compounds (8–11) were discovered from the extract of the deep-sea-derived fungus Penicillium fellutanum HDN14-323. The structures of the new compounds were established through extensive analysis. Their cytotoxic activity against HeLa, HL-60, and HCT-116 cell lines was evaluated, with compound 4 exhibiting the best activity against the HeLa cell line (IC50 = 9.3 µM).
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