H. O. Handwerker

Friedrich-Alexander-Universität Erlangen-Nürnberg

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Co-Authors

E. Fleischer

Georgetown University

U. Petsche

University of Vienna

Peter W. Reeh

Friedrich-Alexander-Universität Erlangen-Nürnberg

E. Welk

Stadtarchiv Worms

M. Zimmermann

Heidelberg University

Fernand Anton

University of Luxembourg

J. Gybels

KU Leuven

A. Kreh

Heidelberg University

H. Adriàensen

Antwerp University Hospital

J. Van Hees

Western Sydney University

Cooperative Institutions

Heidelberg University

165

Czech Academy of Sciences, Institute of Physiology

Ludwig-Maximilians-Universität München

Freie Universität Berlin

Max Planck Society

University of Würzburg

University of Tübingen

Goethe University Frankfurt

Medizinische Hochschule Hannover

Johannes Gutenberg University Mainz

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Nervous outflow from the cat's foot during noxious radiant heat stimulation

Brain Research (1974)

Peter W. Beck H. O. Handwerker M. Zimmermann

Radiant heat

10.1016/0006-8993(74)90488-0

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Citations (331)

Excitability changes of cutaneous c-fibre receptors following a block of axoplasmic transport of neuropeptides by local capsaicin application

Pflügers Archiv - European Journal of Physiology (1982)

E. Welk U. Petsche E. Fleischer H. O. Handwerker

Capsaicin

Axoplasmic transport

10.1007/bf02580803

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Citations (0)

Physiology Nervous outflow from the catʼs foot during noxious radiant heat stimulation

Pain (1976)

Peter W. Beck H. O. Handwerker M. Zimmermann

Pain: December 1976 - Volume 2 - Issue 4 - p 439 doi: 10.1016/0304-3959(76)90086-5

Radiant heat

Foot (prosody)

10.1016/0304-3959(76)90086-5

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Citations (0)

Receptive properties of human a. fibres

Pain (1981)

H. Adriàensen J. Gybels H. O. Handwerker J. Van Hees

aDepartment of Neurology and Neurosurgery, University of Leuven, 3000 Leuven, Belgium bII. Institute of Physiology, University of Heidelberg, 6900 Heidelberg 1, Fed. Rep. Germany

10.1016/0304-3959(81)90310-9

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Citations (1)

Unmyelinated nociceptive units in two skin areas of the rat

Brain Research (1983)

E. Fleischer H. O. Handwerker S. Joukhadar

Radiant heat

Nociceptor

10.1016/0006-8993(83)91041-7

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Citations (151)

How special are muscle nociceptors?

Pain Forum (1997)

H. O. Handwerker

Sympatholytics

10.1016/s1082-3174(97)70013-8

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Citations (0)

Influence of acetylsalicylic and salicylic acid plasma 89 poster levels on psychophysical measures of long standing natural pain stimuli

Pain (1984)

A. Kreh Fernand Anton Peter W. Reeh E. Walter E. Weber

Kreh, A.; Anton, F.; Reeh, P. W.; Walter, E.; Weber, E.; Handwerker, H. O. Author Information

10.1016/0304-3959(84)90222-7

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Neural representation of hair movements in primary afferent fibres and in cortical units of the cat

Pflügers Archiv - European Journal of Physiology (1972)

H. O. Handwerker Marieke Sassen

Representation

Cortical neurons

10.1007/bf00586857

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Citations (9)

Noxious and tactile input to medial structures of midbrain and pons in the rat

Pain (1978)

René Eickhoff H. O. Handwerker Daniel S. McQueen Erich Schick

Response patterns of single units in the medial parts of the pons and midbrain were studied extracellularly in chloralose-anaesthetized rats, paralyzed with oancuronium. The units were tested with natural skin stimuli including slight touch and hair-brushing in order to provide input from sensitive mechanoreceptors supplied by myelinated afferent fibres. Noxious pinch and controlled noxious radiant heat were also used to provide nociceptive input. The influence of these stimuli on unit activity was compared with that evoked by electrical stimulation of the coccygeal nerve, which excited either the A-fibres only or, with stronger stimuli A- and C-fibres. It has been shown that about half the units responding to electrical stimulation of the A-fibres exhibited a second peak of excitation with a latency of 100–300 msec when the stimulus strength surpassed C-fibre threshold. A high and statistically significant correlation has been found to exist between increased excitability induced by noxious heating and/or squeezing the skin on the one hand and the occurrence of a C-fibre response on the other hand. From this evidence it is concluded that a large proportion of the units in the medial pons and midbrain receive nociceptive input from the skin and that this input is mediated predominantly by C-fibres. When applying controlled radiant heat it has been found that the discharge frequencies of units responding to noxious input do not code the stimulus strength exactly, rather the units usually switch from a lower to a higher discharge frequency when noxious levels of stimulation are reached. The functional implications of this are discussed.

Pons

Stimulus (psychology)

Radiant heat

10.1016/0304-3959(78)90032-5

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Citations (53)

Contribution of naturally stimulated D- and G-hair receptors to the excitation of cortical SI-neurons

Pflügers Archiv - European Journal of Physiology (1972)

H. O. Handwerker Marieke Sassen

Cortical neurons

10.1007/bf00592166

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Citations (8)