Anuradha Natarajan

University of British Columbia

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Fábio Rossi

University of British Columbia

Maria Sibilia

Medical University of Vienna

Renate Kroismayr

Institute of Cancer Research

Bettina Wagner

University of Veterinary Medicine Vienna

Darío R. Lemos

Harvard Stem Cell Institute

Regan‐Heng Zhang

University of British Columbia

Hanane Lanaya

Comprehensive Cancer Center Vienna

Martina Hammer

Comprehensive Cancer Center Vienna

Joy Wang

BASIS International (United States)

Michael A. Rudnicki

University Medical Center Groningen

Cooperative Institutions

Medical University of Vienna

University of British Columbia

Comprehensive Cancer Center Vienna

Saveetha University

University of Vienna

Spanish National Cancer Research Centre

Azienda Ospedaliera San Gerardo

Istituti di Ricovero e Cura a Carattere Scientifico

Sapienza University of Rome

University of Cologne

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EGFR has a tumour-promoting role in liver macrophages during hepatocellular carcinoma formation

Nature Cell Biology (2014)

Hanane Lanaya Anuradha Natarajan Karin Komposch Liang Li Nicole Amberg

Liver Cancer

10.1038/ncb3031

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Citations (217)

Nilotinib reduces muscle fibrosis in chronic muscle injury by promoting TNF-mediated apoptosis of fibro/adipogenic progenitors

Nature Medicine (2015)

Darío R. Lemos Farshad Babaeijandaghi Marcela Low Chih-Kai Chang Sunny T Lee

10.1038/nm.3869

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Citations (598)

Fibro/adipogenic progenitors: A double-edged sword in skeletal muscle regeneration

Cell Cycle (2010)

Anuradha Natarajan Darío R. Lemos Fábio Rossi

Comment on: Joe AWB, et al. Nat Cell Biol 2010; 12:153-163.

SWORD

10.4161/cc.9.11.11854

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Citations (75)

Cancer may be induced by microplastics-sorbed polycyclic aromatic hydrocarbons?

Oral Oncology Reports (2024)

Ashok K. Sundramoorthy Anandavalli Baskar Anuradha Natarajan Raji Atchudan Sandeep Arya

• MPs are plastics that originated from the breakdown of larger plastic waste. • MPs are particles of plastics with size ranging from 1 nm to 5 mm. • Persistent organic pollutants compounds leading to various cancers. • MPs boosted metastatic characteristics in cancer cells. • MPs-PAH have a high tendency to induce cancer risk in humans.

10.1016/j.oor.2023.100150

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Citations (1)

Neuronal survival depends on EGFR signaling in cortical but not midbrain astrocytes

The EMBO Journal (2006)

Bettina Wagner Anuradha Natarajan Sabine Grünaug Renate Kroismayr Erwin F. Wagner

10.1038/sj.emboj.7600988

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Citations (118)

The epidermal growth factor receptor: from development to tumorigenesis

Differentiation (2007)

Maria Sibilia Renate Kroismayr Beate M. Lichtenberger Anuradha Natarajan Manfred Hecking

ERBB3

ERBB4

ErbB

Cell type

Cyclin-dependent kinase 8

10.1111/j.1432-0436.2007.00238.x

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Citations (330)

Nonmyogenic Cells in Skeletal Muscle Regeneration

Current topics in developmental biology/Current Topics in Developmental Biology (2011)

Ben Paylor Anuradha Natarajan Regan‐Heng Zhang Fábio Rossi

10.1016/b978-0-12-385940-2.00006-1

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Citations (48)

Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis

Nature Cell Biology (2010)

Aaron W. Joe Lin Yi Anuradha Natarajan Fabien Le Grand Leslie So

Progenitor

10.1038/ncb2015

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Citations (1,473)

The EGF receptor is required for efficient liver regeneration

Proceedings of the National Academy of Sciences (2007)

Anuradha Natarajan Bettina Wagner Maria Sibilia

Mice lacking the EGF receptor (EGFR) die between midgestation and postnatal day 20 with various defects in neural and epithelial organs. Here, we generated mice carrying a floxed EGFR allele to inactivate the EGFR in fetal and adult liver. Perinatal deletion of EGFR in hepatocytes resulted in decreased body weight, whereas deletion in the adult liver did not affect body mass. Although liver function was not affected, after partial hepatectomy mice lacking EGFR in the liver showed increased mortality accompanied by increased levels of serum transaminases indicating liver damage. Liver regeneration was delayed in the mutants because of reduced hepatocyte proliferation. Analysis of cell cycle progression in EGFR-deficient livers indicated a defective G(1)-S phase entry with delayed transcriptional activation and reduced protein expression of cyclin D1 followed by reduced cdk2 and cdk1 expression. Impaired liver regeneration was accompanied by compensatory up-regulation of TNFalpha in the serum and prolonged activation of c-Jun. Moreover, p38alpha and NF-kappaB activation was reduced in regenerating mutant livers, indicating an impaired stress response after hepatectomy. Our studies demonstrate that EGFR is a critical regulator of hepatocyte proliferation in the initial phases of liver regeneration.

Liver Regeneration

10.1073/pnas.0704126104

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Citations (297)