Motoyoshi Satake

Ochanomizu University

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Setsuko Sekita

Showa Pharmaceutical University

Nobuo Kawahara

National Institute of Biomedical Innovation, Health and Nutrition

Hiroyuki Fuchino

National Institute of Biomedical Innovation, Health and Nutrition

Osamu Shirota

Tokushima Bunri University

Yukihiro Ozaki

Kwansei Gakuin University

Masanori Kuroyanagi

Prefectural University of Hiroshima

Kanami Mori-Yasumoto

Tokyo University of Science

Hideji Itokawa

University of North Carolina at Chapel Hill

Koichiro Shimomura

National Agriculture and Food Research Organization

Hiroshi Morita

Hoshi University

Cooperative Institutions

National Institute of Health Sciences

The University of Tokyo

Chiba University

Kyoto University

Osaka University

Hiroshima University

Kumamoto University

National Institute of Health Sciences

Tohoku University

Hoshi University

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Alkaloid Production by Hairy Root Cultures in Atropa belladonna

福山大学薬学部研究年報 = Annual report of the Faculty of Pharmacy & Pharmaceutical Sciences, Fukuyama University (1987)

信幸岡村ヒロシカマダノブユキオカムラモトヨシサタケヒロシハラダ

Atropa belladonna

Hairy Root Culture

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Citations (0)

Colony Stimulating Factor-Inducing Activity of IsoflavoneC-Glucosides from the Bark ofDalbergia monetaria

Planta Medica (1998)

Kiichiro Kawaguchi Sérgio de Mello Alves Takashi Watanabe Seiichi Kikuchi Motoyoshi Satake

To obtain immunomodulating substances from Amazonian medicinal plants, hot water extracts from 21 samples available commercially were tested in terms of mitogenic and colony-stimulating factor (CSF)-inducing activities. Among them, Dalbergia monetaria exhibited the highest CSF-inducing activity. Orobol 8-C-glucoside (OCG-8) and orobol 6-C-glucoside (OCG-6) were isolated from the bark of D. monetaria as major constitutents. The CSF-inducing activity of OCG-8 was higher than that of OCG-6 and a dose-dependent manner at a range of 0.1-l0 mg/mouse. Serum CSF production induced by an intraperitoneal (i.p.) injection with 1 mg OCG-8 reached a peak at 4-6 h later, suggesting that OCG-8 would act on hematopoietic system.

Glucoside

10.1055/s-2006-957541

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Citations (10)

Phenylpropanoid derivatives from edible canna, Canna edulis

Phytochemistry (2004)

Young Sook Yun Motoyoshi Satake Shigeki Katsuki Akira Kunugi

Phenylpropanoid

Canna

10.1016/j.phytochem.2004.06.003

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Citations (25)

Physicochemical quality evaluation of natural compounds isolated from crude drugs $60#?"Art",13,"Introduction",5,0,0,0,100mm,100mm,100mm,100mm>Standard com- pounds for the official specification and testing method of ''Processed Aconite Root'' and ''Powdered Processed Aconite Root'' in the Japanese Pharmacopoeia

Yuichi Nakamura Kaori Yomura Toshihiro Kammoto Makoto Ishimatsu Yuichi Kikuchi

Aconite root has high toxicity caused by diester alkaloids, thus it was necessary to define the limiting value of diester alkaloids used in medicine formulation. To give the quality of ''Processed Aconite Root'' and ''Powdered Processed Aconite Root'' in the Japanese Pharmacopoeia (14th edn, supplement II), we established the official specification and evaluation methods of standard substances. High qualitative grade diester alkaloids, aconitine, hypaconitine, jesaconitine and mesaconitine, which were useful to evaluate the purity of processed aconite root and powdered pro- cessed aconite root, were prepared and evaluated for their stability. We studied the physicochemical speci- fication and evaluation methods of these alkaloids. In addition, an ''Aconitum diester alkaloids standard solution for purity'', which was used for the purity test, was prepared, and we also studied its physicochemical specification and evaluation methods. In addition, to evaluate the quality of processed aconite root and powdered processed aconite root, a TLC identification test was established. A monoester alkaloid of ben- zoylmesaconine hydrochloride was used as the refer- ence standard in the latter test, and we also investigated its physicochemical specification and evaluation methods.

Aconitine

Quality standard

Aconitum

Pharmacopoeia

Limiting

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Genetic Identification of Cinnamon (Cinnamomum spp.) Based on the trnL-trnF Chloroplast DNA

Planta Medica (2002)

Mareshige Kojoma Kogo Kurihara Kazuya Yamada Setsuko Sekita Motoyoshi Satake

Genetic identification among cinnamon species was studied by analyzing nucleotide sequences of chloroplast DNA from four species (Cinnamomum cassia, C. zeylanicum, C. burmannii and C. sieboldii). The two regions studied were the intergenic spacer region between the trnL 3'exon and trnF exon (trnL -trnF IGS) and the trnL intron region. We found nucleotide variation at one site in the trnL-trnF IGS, and at three sites in the trnL intron. With the sequence data from analysis of these regions, the four Cinnamomum species used in this study were correctly identified. Furthermore, single-strand conformation polymorphism (SSCP) analysis of PCR products from the trnL-trnF IGS and the trnL intron resulted in different SSCP band patterns among C. cassia, C. zeylanicum and C. burmannii.

Cinnamomum

Cinnamomum zeylanicum

Single-strand conformation polymorphism

Intergenic region

10.1055/s-2002-20051

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Citations (56)

Intraspecific Variation in Cannabis sativa L. Based on Intergenic Spacer Region of Chloroplast DNA.

Biological and Pharmaceutical Bulletin (2000)

Mareshige Kohjyouma I‐Jung Lee Osamu Iida Kogo Kurihara Kazuya Yamada

We analyzed the nucleotide sequences of the non-coding region of chloroplast DNA : the intergenic spacer between trnL (UAA) 3'exon and trnF (GAA). Two kinds of sequence, "type-1" and "type-2", were detected in 33 populations of Cannabis sativa. The length of the "type-1" fragment was 354 bp. In contrast, the "type-2" fragment from 3 populations was 353 bp long, with only one base deletion compared to "type-1." The fragment length from Humulus lupulus was 353 bp with a 1-bp deletion, and ten 1-bp substitutions compared to the sequences from C. sativa "type-1." Furthermore, we could clearly identify differences between C. sativa and H. lupulus using single-strand conformation polymorphism of PCR products (PCR-SSCP) analysis.

Intergenic region

Humulus lupulus

Coding region

Spacer DNA

Inverted repeat

Single-strand conformation polymorphism

Indel

10.1248/bpb.23.727

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Citations (37)

Antiandrogenic phenolic constituents from Dalbergia cochinchinensis

Phytochemistry (1997)

Vibha Pathak Osamu Shirota Setsuko Sekita Yutaka Hirayama Yusuke Hakamata

Dalbergia

10.1016/s0031-9422(97)80015-5

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Citations (40)

Dammarane-Type Triterpenes from the Brazilian Medicinal Plant Cordia multispicata

Journal of Natural Products (2003)

Masanori Kuroyanagi Nobuo Kawahara Setsuko Sekita Motoyoshi Satake Tatsuo Hayashi

From the Brazilian medicinal plant Carucaá (Cordia multispicata), oleanane- and ursane-type triterpenoids were previously reported as anti-androgenic constituents of the plant. In this study, purification of the polar elements of the EtOAc-soluble fraction of the plant revealed nine novel dammarane-type triterpenes, named cordianols A-I (1-9) along with the known compound cordialin A (10). The structures of these new compounds were elucidated by means of spectral methods including HRFABMS, (1)H NMR, (13)C NMR, and 2D NMR (HMQC, HMBC, NOESY). Absolute configuration at C-23 of compound 7 was determined by an excitone chirality method. Some of these new compounds revealed a hemiketal structure on the A ring and a hydroxylated or epoxidated 20(22)-(E)-ene side chain and showed weak anti-androgenic activity.

Dammarane

Oleanane

Terpene

Absolute Configuration

Chirality

10.1021/np020483f

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Citations (19)

Study of the Accelerating Effect of Shikonin and Alkannin on the Proliferation of Granulation Tissue in Rats.

Biological and Pharmaceutical Bulletin (1998)

Yukihiro Ozaki Ikuyo Sakaguchi Masae TUJIMURA Norikazu Ikeda Miki Nakayama

The present study was carried out to compare the accelerating effect of shikonin and alkannin and to elucidate the expression of CD antigen and histological changes on the proliferation of granulation tissue in rats. Shikonin and alkannin produced a dose-dependent acceleration of the cotton pellet-induced granuloma formation and this accelerating potency of both compounds on the proliferation of granulation tissue was about the same 5 and 10 d after implantation of the cotton pellet. Also, both compounds increased the ratio of CD11b+ cells in the granulation tissue 5 and 10 d after implantation of the cotton pellet. Both compounds increased the expression of CD11b+ cells with granulocytes such as macrophages and histiocytes, and then accelerated the proliferation of fibroblasts and collagen fiber. On the other hand, neither compound increased the ratio of CD3+ cells in the granulation tissue after 5 and 10 d. These results suggest that shikonin and alkannin accelerate the proliferation of granulation tissue induced by the cotton pellet and this accelerating effect may be attributed to an increase in the expression of CD11b+ cells, and the acceleration of the proliferation of fibroblasts and collagen fiber in the granulation tissue.

Granulation tissue

Granulation

10.1248/bpb.21.366

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Citations (24)

Morphological, chemical and molecular biological comparison among Artemisia capillaris, A. japonica and their natural hybrids

生薬學雜誌 (2003)

Motoyasu Minami Keizo Hosokawa Md. Wahiduzzaman Mia Eiji Sakai Motoyoshi Satake

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Citations (2)