Rongrong Han

Northwestern Polytechnical University

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Yan Shen

Wuhan National Laboratory for Optoelectronics

Zeyue Liu

Foshan University

Qi Xu

Chinese Academy of Sciences

Jianbo Xiu

Chinese Academy of Medical Sciences & Peking Union Medical College

Yanguang Song

Pennsylvania State University

Shiyun Ai

Shandong Agricultural University

Yu‐Qiang Ding

Fudan University

Jiayu Li

First Affiliated Hospital of Xi'an Jiaotong University

Shu Liu

Changchun Institute of Applied Chemistry

Bin Yang

Shaanxi University of Science and Technology

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Chinese Academy of Sciences

Capital Medical University

Tsinghua University

Northwestern Polytechnical University

Peking University

Chinese Academy of Medical Sciences & Peking Union Medical College

Ministry of Agriculture and Rural Affairs

Chongqing Medical University

Shandong Agricultural University

Taian City Central Hospital

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マウス脳虚血モデルにおける低酸素ポストコンディショニング促進解糖【JST・京大機械翻訳】

Brain Research (2020)

Changhong Ren Rongrong Han Jiangnan Hu Haiyan Li Li Sijie

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Influence of growth velocity on degenerate pattern evolution in Al-4.5 wt% Cu during non-axially oriented directional solidification

Journal of Crystal Growth (2019)

Yumin Wang Shuangming Li Bin Yang Rongrong Han Hong Zhong

Directional solidification

Dimensionless quantity

Axial symmetry

10.1016/j.jcrysgro.2019.125252

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A Recyclable Biochar with Ultrahigh Absorption Ability for Efficient Removal Of Tetracycline Hydrochloride

junling Duan Rongrong Han Yanguang Song Shiyun Ai

Tetracycline Hydrochloride

Hydrochloride

10.2139/ssrn.4861403

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Hijacking Dorsal Raphe to Improve Metabolism and Depression-like Behaviors via BDNF Gene Transfer in Mice

Jianbo Xiu Rongrong Han Zeyue Liu Jiayu Li Shu Liu

Moods and metabolism modulate each other. High comorbidity of depression and metabolic disorders such as diabetes and obesity poses a great challenge to treat such condition. Here we report the therapeutic efficacy of brain-derived neurotrophic factor (BDNF) by gene transfer in the dorsal raphe nucleus (DRN) in a chronic unpredictable mild stress model of depression (CUMS) and models of diabetes and obesity. In CUMS, BDNF-expressing mice displayed antidepressant- and anxiolytic-like behaviors, which are associated with augmented serotonergic activity. Both in the diet-induced obesity model (DIO) and in <i>db/db</i> mice，BDNF ameliorated obesity and diabetes, which may be mediated by enhanced sympathetic activity, not involving DRN serotonin. Chronic activation of DRN neurons via chemogenetic tools produced similar effects as BDNF in DIO mice. These results established the DRN as a key nexus in regulating depression-like behaviors and metabolism, which can be exploited to combat comorbid depression and metabolic disorders via BDNF gene transfer.

Dorsal raphe nucleus

10.2337/figshare.14531346

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非軸方向に配向した方向性凝固中のAl-4.5wt%Cuにおける縮退パターン発展に及ぼす成長速度の影響【JST・京大機械翻訳】

Journal of Crystal Growth (2019)

Wang Yu-min Li Shuangming Yang Bin Rongrong Han Zhong Hong

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Hijacking Dorsal Raphe to Improve Metabolism and Depression-like Behaviors via BDNF Gene Transfer in Mice

Jianbo Xiu Rongrong Han Zeyue Liu Jiayu Li Shu Liu