Ameneh Bakhtiari

University of Isfahan

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Seyyed Mansour Seyyednejad

Shahid Chamran University of Ahvaz

Hossein Motamedi

Shahid Chamran University of Ahvaz

Mozhan Vafaei

Shahid Chamran University of Ahvaz

Mohammad Irani

Alborz University of Medical Sciences

Azadeh Jafari Rad

Islamic Azad University, Omidieh Branch

Fariborz Sharifianjazi

University of Georgia

Amirhossein Moghanian

Imam Khomeini International University

Amirhossein Esmaeilkhanian

Amirkabir University of Technology

Daruosh Rahban

Tehran University of Medical Sciences

Firoozeh Niazvand

Ilam University

Cooperative Institutions

Amirkabir University of Technology

Shahid Chamran University of Ahvaz

Tehran University of Medical Sciences

Sharif University of Technology

Semnan University

Islamic Azad University, Tehran

Seoul National University

Islamic Azad University Medical Branch of Tehran

University of Tehran

University of Georgia

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Tagetes erecta, A Potential Medicinal Plant for Discovering a New Antibacterial Agent

Jentashapir Journal of Health Research (2015)

Hossein Motamedi Seyyed Mansour Seyyednejad Ameneh Bakhtiari Mozhan Vafaei

Background: Tagetes genus contains 56 species and is native in North and South America, but some have become widespread around the world. Objectives: This study was designed to examine the antibacterial potential of methanolic and ethanolic extracts of Tagetes erecta. Materials and Methods: Hydroalcoholic extracts from aerial parts of this plant were prepared using aqueous solution of ethanol and methanol (8:2 v/v). The inhibitory effect of 1.5, 3, 6, 12 and 18 mg of effective dose per disc of these extracts was discovered against clinical bacterial isolates including three Gram-positive bacteria: Bacillus cereus, Staphylococcus aureus and S. epidermidis and five Gram-negative bacteria: Salmonella Typhi, Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa and Proteus mirabilis. Minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and time kill kinetic assay of these extracts were also investigated. Scanning electron microscopy (SEM) analysis was performed to find possible structural changes following exposure to the extract. Results: Both extracts of T. erecta were active against B. cereus, S. aureus, S. epidermidis and S. Typhi. Hydroalcoholic extracts of T. erecta showed significant antibacterial effects against some clinically important pathogenic bacteria. These extract also caused deformation and lysis of bacterial cells, as shown by SEM. Conclusions: These extracts can be used as antibacterial agents in treating infectious diseases. Further studies are needed for considering this plant as an antibacterial plant and benefit from its clinical applications for routine use.

Tagetes

Minimum bactericidal concentration

Pathogenic bacteria

10.5812/jjhr.29744

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Citations (4)

Tagetes erecta, A Potential Medicinal Plant for Discovering a New Antibacterial Agent

Jentashapir Journal of Health Research (2015)

Hossein Motamedi Seyyed Mansour Seyyednejad Ameneh Bakhtiari Mozhan Vafaei

Tagetes

10.17795/jjhr-29744

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Citations (4)

Magnetic bioactive glasses/Cisplatin loaded-chitosan (CS)-grafted- poly (ε-caprolactone) nanofibers against bone cancer treatment

Carbohydrate Polymers (2021)

Zahra Amini Sam Shekofte Rudsary Seyed Sadegh Shahraeini Babak Faraji Dizaji Pouya Goleij

Caprolactone

Electrospinning

10.1016/j.carbpol.2021.117680

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Citations (42)

Photosensitive nanocomposites: environmental and biological applications

Journal of Composites and Compounds (2020)

Ho Won Jang Amir Zareidoost Mostafa Moradi Aliasghar Abuchenari Ameneh Bakhtiari

There has been an extensive investigation in the field of optical applications of nanocomposite materials. To prepare photosensitive nanocomposites, an optically functional phase is embedded in a transparent, processable matrix. This provides the opportunity to utilize the optical properties in other forms including fibers and films, which are more technologically important. Due to expansion of optical materials applications, novel transparent materials and optically functional are required. Recent optical nanocomposites and their applications in different areas especially catalysis and drug delivery have been addressed in this paper.

10.29252/jcc.2.1.7

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The Antibacterial Activity of Cassia fistula Organic Extracts

Jundishapur Journal of Microbiology (2014)

Seyyed Mansour Seyyednejad Hossein Motamedi Mouzhan Vafei Ameneh Bakhtiari

Cassia fistula, is a flowering plant and a member of Fabaceae family. Its leaves are compound of 4 - 8 pairs of opposite leaflets. There are many Cassia species around the world which are used in herbal medicine.This study was designed to examine in vitro anti-bacterial activity of methanolic and ethanolic extracts of C. fistula native to Khuzestan, Iran.The microbial inhibitory effect of methanolic and ethanolic extracts of C. fistula was tested on 3 Gram positive: Bacillus cereus, Staphylococcus aureus and S. epidermidis and 5 Gram negative: Salmonella Typhi, Kelebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa, and Proteus mirabilis bacterial species using disc diffusion method at various concentrations. The minimum inhibitory and bactericidal concentrations (MIC and MBC) were measured by the tube dilution assay.The extract of C. fistula was effective against B. cereus, S. aureus, S. epidermidis, E. coli and K. pneumoniae. The most susceptible microorganisms to ethanolic and methanolic extracts were E. coli and K. pneumoniae, respectively. Also B. cereus and S. aureus showed the least sensitivity to ethanolic and methanolic extracts, respectively. The MIC (minimum inhibitory concentration) and MBC (minimum bactericidal concentration) of ethanolic extracts against S. aureus, E. coli, S. epidermidis and K. pneumoniae were also determined.With respect to the obtained results and regarding to the daily increase of the resistant microbial strains to the commercial antibiotics, it can be concluded that these extracts can be proper candidates of antibacterial substance against pathogenic bacterial species especially S. aureus, E. coli, K. pneumoniae and S. epidermidis.

Minimum bactericidal concentration

Cereus

10.5812/jjm.8921

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Citations (31)

Introducing Urtica dioica, A Native Plant of Khuzestan, As an Antibacterial Medicinal Plant

Jundishapur Journal of Natural Pharmaceutical Products (2014)

Hossein Motamedi Seyyed Mansour Seyyednejad Ameneh Bakhtiari Mozhan Vafaei

Background: Urtica dioica is a flowering plant with long history of use in folk medicine and as a food source. Objectives: This study examined in vitro antibacterial potential of alcoholic extracts of U. dioica. Materials and Methods: Hydroalcoholic extracts from aerial parts were prepared using aqueous solution of ethanol and methanol and their inhibitory effects against clinical isolates was examined by disc diffusion method at different doses. Minimum inhibitory concentrations (MIC) and minimum bactericidal concentration (MBC) indexes were also investigated. The scanning electron microscopy (SEM) analysis was also performed to find structural changes of affected bacteria consequent to exposing with extracts. Results: Both extracts were active against Bacillus cereus, Staphylococcus aureus, Staphylococcus epidermidis, and Escherichia coli with respectively 16, 10, 18, and 14 mm (methanolic) and 11, 9, 17, and 16 mm (ethanolic) inhibition zone. The MIC of ethanolic extract against S. epidermidis and E. coli was respectively 10 and 40 mg/mL. The MIC of methanolic extract against S. aureus and S. epidermidis was 40 and 10 mg/mL, respectively. The MBC was found only for S. epidermidis (20 mg/mL). In SEM analysis the round shape of S. epidermidis was changed and irregular shapes were appeared, which suggest that the main target of these extracts was cell wall. Conclusions: Extracts of U. dioica showed significant antibacterial effect against some clinically important pathogenic bacteria. Based on the obtained results it can be concluded that U. dioica is useful as antibacterial and bactericidal agent in treating infectious diseases.

Urtica dioica

Minimum bactericidal concentration

Agar diffusion test

Pathogenic bacteria

10.17795/jjnpp-15904

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Citations (21)

Biosensors and nanotechnology for cancer diagnosis (lung and bronchus, breast, prostate, and colon): a systematic review

Biomedical Materials (2021)

Fariborz Sharifianjazi Azadeh Jafari Rad Ameneh Bakhtiari Firoozeh Niazvand Amirhossein Esmaeilkhanian

Abstract The second cause of death in the world has been reported to be cancer, and it has been on the rise in recent years. As a result of the difficulties of cancer detection and its treatment, the survival rate of patients is unclear. The early detection of cancer is an important issue for its therapy. Cancer detection based on biomarkers may effectively enhance the early detection and subsequent treatment. Nanomaterial-based nanobiosensors for cancer biomarkers are excellent tools for the molecular detection and diagnosis of disease. This review reports the latest advancement and attainment in applying nanoparticles to the detection of cancer biomarkers. In this paper, the recent advances in the application of common nanomaterials like graphene, carbon nanotubes, Au, Ag, Pt, and Fe 3 O 4 together with newly emerged nanoparticles such as quantum dots, upconversion nanoparticles, inorganics (ZnO, MoS 2 ), and metal–organic frameworks for the diagnosis of biomarkers related to lung, prostate, breast, and colon cancer are highlighted. Finally, the challenges, outlook, and closing remarks are given.

Nanomaterials

10.1088/1748-605x/ac41fd

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Citations (42)

Synthesis and characterization of the novel 80S bioactive glass: bioactivity, ‎biocompatibility, cytotoxicity

Journal of Composites and Compounds (2020)

Ameneh Bakhtiari Amir Cheshmi Maryam Naeimi Sobhan Mohammadi Fathabad Maryam Aliasghari

In this research, the 80S bioactive glass with different Ca/P ratios was prepared by the sol-gel route. Scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy dispersive spectroscopy (EDS), X-ray diffraction (XRD), and Fourier transforms infrared spectroscopy (FTIR) were used to study the apatite structure and shape. According to the results, the 78SiO2–17P2O5–5CaO bioglass showed a higher rate of crystalline hydroxyapatite (HA) on its surface in comparison with the other bioglasses. After 3 days of immersion in the SBF solution, spherical apatite was formed on the 78SiO2–17P2O5–5CaO surface, which demonstrated high bioactivity. A statistically significant promotion in proliferation and differentiation of G292 osteoblastic cells was also observed. Regarding its optimal cell viability and bioactivity, the 78SiO2–17P2O5–5CaO bioactive glass could be offered as a promising candidate for bone tissue applications.

Biocompatibility

Bioactive Glass

Simulated body fluid

Energy-dispersive X-ray spectroscopy

10.29252/jcc.2.3.1

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Citations (16)