Alessandra D’Angelo

University of Rhode Island

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Cristina Maccallini

University of Chieti-Pescara

Barbara De Filippis

University of Chieti-Pescara

Letizia Giampietro

University of Chieti-Pescara

Rosa Amoroso

University of Chieti-Pescara

Marialuigia Fantacuzzi

University of Chieti-Pescara

Alessandra Ammazzalorso

University of Chieti-Pescara

Antonella Giancristofaro

University of Chieti-Pescara

Lidia Gauna

National University of Comahue

Pasquale Linciano

University of Pavia

A. Caballero de Castro

National University of Comahue

Cooperative Institutions

University of Chieti-Pescara

University of Palermo

National University of Comahue

John Wiley & Sons (United States)

Hudson Institute

Consejo Nacional de Investigaciones Científicas y Técnicas

Alfred-Wegener-Institut Helmholtz-Zentrum für Polar- und Meeresforschung

Istituto di Farmacologia Traslazionale

Istituti di Ricovero e Cura a Carattere Scientifico

Azienda Ospedaliera Universitaria Policlinico "Paolo Giaccone" di Palermo

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European Neurology (2000)

J.L.A. Eekhof M. Aramideh J.D. Speelman P. P. Devriese B.W. Ongerboer de Visser

10.1159/000008165

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Mechanisms of resistance to DDT and pyrethroids in Patagonian populations of Simulium blackflies

Medical and Veterinary Entomology (2003)

Cristina M. Montagna Olga L. Anguiano Lidia Gauna Alessandra D’Angelo

Mixed populations of the pest blackflies Simulium bonaerense Coscarón & Wygodzinsky, S. wolffhuegeli (Enderlein) and S. nigristrigatum Wygodzinsky & Coscarón (Diptera: Simuliidae) are highly resistant to DDT and pyrethroids in the Neuquén Valley, a fruit-growing area of northern Patagonia, Argentina. As these insecticides have not been used for blackfly control, resistance is attributed to exposure to agricultural insecticides. Pre-treatment with the synergist piperonyl butoxide (PBO) reduced both DDT and fenvalerate resistance, indicating that resistance was partly due to monooxygenase inhibition. Pre-treatment with the synergist tribufos to inhibit esterases slightly increased fenvalerate toxicity in the resistant population. Even so, biochemical studies indicated almost three-fold higher esterase activity in the resistant population, compared to the susceptible. Starch gel electrophoresis confirmed higher frequency and staining intensity of esterase electromorphs in the resistant population. Incomplete synergism against metabolic resistance indicates additional involvement of a non-metabolic resistance mechanism, such as target site insensitivity, assumed to be kdr-like in this case. Glutathione S-transferase activities were low and inconsistent, indicating no role in Simulium resistance. Knowing these spectra of insecticide activity and resistance mechanisms facilitates the choice of more effective products for Simulium control and permits better coordination with agrochemical operations.

Piperonyl butoxide

Esterase

Fenvalerate

Agricultural pest

Insecticide Resistance

10.1046/j.1365-2915.2003.00401.x

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Citations (15)

Discovery of gemfibrozil analogues that activate PPARα and enhance the expression of gene CPT1A involved in fatty acids catabolism

European Journal of Medicinal Chemistry (2011)

Barbara De Filippis Antonella Giancristofaro Alessandra Ammazzalorso Alessandra D’Angelo Marialuigia Fantacuzzi

Gemfibrozil

Chalcone

Catabolism

10.1016/j.ejmech.2011.08.022

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Citations (28)

Prenatal exposure to pesticides: analysis of human placental acetylcholinesterase, glutathione S-transferase and catalase as biomarkers of effect

Biomarkers (2005)

María Sol Souza Gladis Magnarelli María Gabriela Rovedatti Silvia Santa Cruz Alessandra D’Angelo

Pre- and perinatal exposure to pesticides is deleterious on foetal and neonatal development, but information regarding possible effects on environmental low-dose exposure to pesticides is scarce. Most epidemiological studies of the health effect of pesticides have been based on self-reported information. However, detailed information on past pesticide use is difficult to reconstruct. This is a current study conducted among pregnant mothers attending a delivery care and perinatal programme at a public hospital. The study investigates biomarkers of early effects in placentas from women living in an area with an intensive use of pesticides in the northern part of Patagonia, province of Río Negro, Argentina, and it assesses the consistency of the information provided by self-reports. The study confirms that placental acetylcholinesterase and catalase activities are significantly associated with periods of organophosphorus pesticides application, while glutathione S-transferase is not affected. We found a positive correlation between environmental exposure to organophosphorus pesticides and carbamate insecticides and newborn head circumference. The findings provide a further indication of a link between placenta acetylcholinesterase and catalase activity and prenatal exposure to pesticides in population studies. Both placenta enzymes may be used as biomarkers in health surveillance programmes for early diagnosis of exposure related alterations produced by organophosphorus pesticides and carbamate pesticides.

Carbamate

10.1080/13547500500272614

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Citations (41)

Removal of azinphos methyl by alfalfa plants (Medicago sativa L.) in a soil-free system

The Science of The Total Environment (2004)

Cecilia G. Flocco M. P. Carranza Loreto Carvajal Ruth M. Loewy Alessandra D’Angelo

Medicago sativa

10.1016/j.scitotenv.2003.08.024

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Citations (22)

Reversed-phase high-performance liquid chromatography method with fluorescence detection to screen nitric oxide synthases inhibitors

Journal of Separation Science (2014)

Cristina Maccallini Mauro Di Matteo Alessandra Ammazzalorso Alessandra D’Angelo Barbara De Filippis

Nitric oxide synthase (NOS) inhibitors are potential drug candidates due to the critical role of an excessive production of nitric oxide in a range of diseases. At present, the radiometric detection of l-[3H]-citrulline produced from l -[3H]-arginine during the enzymatic reaction is one of the most accepted methods to assess the in vitro activity of NOS inhibitors. Here we report a fast, easy, and cheap reversed-phase high-performance liquid chromatography method with fluorescence detection, based on the precolumn derivatization of l-citrulline with o-phthaldialdehyde/N-acetyl cysteine, for the in vitro screening of NOS inhibitors. To evaluate enzyme inhibition by the developed method, N-[3-(aminomethyl)benzyl]acetamidine, a potent and selective inhibitor of inducible NOS, was used as a test compound. The half maximal inhibitory concentration obtained was comparable to that derived by the well-established radiometric assay.

10.1002/jssc.201400059

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Citations (10)

Against Human Trafficking: la clinica legale come strategia innovativa di contrasto alla tratta

Cecilia Piera Blengino Silvia Mondino Alessandra D’Angelo Stege Ulrich

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Generating glycan variants for biological activity testing by means of parallel experimental design and multivariate analysis

David Bruehlmann Martin Jordan Michael Sokolov Alessandro Butté Abhijeet Satwekar

Sequential analysis

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PERCOLACION DE PLAGUICIDAS EN AREAS DE PRODUCCION FRUTICOLA EN EL VALLE DEL RIO NEUQUEN (ARGENTINA).

DOAJ (DOAJ: Directory of Open Access Journals) (2000)

R.M Loewy M Novelli L.G Carvajal H. Labollita Glaucia Neme

Para evaluar el posible impacto de los plaguicidas utilizados en la fruticultura sobre las aguas subterraneas poco profundas se diseno un programa de monitoreo de 30 freatimetros instalados en una zona de produccion fruticola de la Provincia de Neuquen (Argentina). El mismo fue ejecutado entre los meses de octubre a marzo de 1995 a 1998. Se pudo determinar que algunos insecticidas como metil azinfos poseian una alta frecuencia de aparicion (65.5% de las muestras) en concentraciones que variaban entre la no deteccion y 79.3 ppb.; dimetoato, metidation y fosmet fueron otro grupo de insecticidas encontrados con frecuencias del 14.4; 12.9 y 9.9 % y en un rango de concentraciones menores que variaba entre la ausencia de deteccion y un valor maximo de 10.9; 2.0 y 15.5 ppb respectivamente. El analisis estadistico permitio establecer una correlacion entre la altura de la napa freatica y la concentracion de metil azinfos asi como entre el periodo transcurrido desde la aplicacion y la toma de muestra. Las diferencias en la movilidad y persistencia de los plaguicidas; la lluvia y el riego condicionaron su grado de lixiviacion, debiendo considerarse estos factores y la toxicidad del compuesto para definir su impacto potencial sobre el ecosistema.

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Are the Myokines the Mediators of Physical Activity-Induced Health Benefits?

Current Pharmaceutical Design (2016)

Domenico Di Raimondo Antonino Tuttolomondo Gaia Musiari Caterina Schimmenti Alessandra D’Angelo

Background: The concept of the muscle as a secretory organ, developed during the last decades, partially answers to the issue of how the crosstalk between skeletal muscle and distant tissues happens. The beneficial effects of exercise transcend the simple improved skeletal muscle functionality: systemic responses to exercise have been observed in distal organs like heart, kidney, brain and liver. Increasing data have accumulated regarding the synthesis, the kinetics of release and the biological roles of muscular cytokines, now called myokines. The most recent techniques have meaningfully improved the identification of the muscle cell secretome, but several issues regarding the extent of secretion from the muscle as well as the actions of the myokines remain unexplained. Methods: The goal of this review is to provide an update about the secretory properties of skeletal muscle during and after an acute bout of exercise and after exercise training, showing the main experimental evidences, but also speculate about the possible therapeutic use of the physical training-induced circulating factors, especially in some categories of patients in which the baseline conditions are heavily damaged by one or more pathological conditions. Results: studies on myokines are relatively recent, and to date most of the evidence available in humans has focused on the biological role of Il-6 during muscle contraction. Regarding to the myokines more recently identified, for example myostatin, fibroblast growth factor 21 (FGF21), secreted protein acidic and rich in cysteine (SPARC) or follistatin-like 1 some of these seem to be promising therapeutic agents, but our awareness about their potential benefits towards human health is only at the beginning. Conclusion: for many of the myokines identified to date, the information available is limited and not enough to characterize precise functions and activities carried out by those in man. Several issues need to be addressed by future studies, tailored to ascertain accurately and surely the biological role and the therapeutic potential of some myokines. Keywords: Myokines, acute exercise, exercise training, cytokines.

Myokine

Myostatin

Follistatin

FGF21

10.2174/1381612822666160429121934

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Citations (31)