Jiaojiao Ma

Collaborative Innovation Center of Chemistry for Energy Materials

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Shaoyou Lu

Sun Yat-sen University

Xuehua Xi

China-Japan Friendship Hospital

Liu Hong

Xijing Hospital

Jiajia Tang

Chinese Academy of Medical Sciences & Peking Union Medical College

Huilin Li

Sichuan University

Quanzhi Zheng

Sun Yat-sen University

Wanli Yang

National Clinical Research Center for Digestive Diseases

Daiming Fan

Air Force Medical University

Xiangyu Li

Leibniz Institute for Baltic Sea Research

Jiayi Xu

Yunnan Agricultural University

Cooperative Institutions

Sun Yat-sen University

Chinese Academy of Sciences

Air Force Medical University

Chinese Academy of Medical Sciences & Peking Union Medical College

Wuhan University

Shanghai Jiao Tong University

Sichuan University

Fudan University

Huazhong University of Science and Technology

Central South University

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Effect of Clopidogrel Combined with Atorvastatin on Serum Lipids, Inflammatory Factors and Cardiac Function Parameters in Patients with Angina Pectoris and Coronary Heart Disease

Pakistan Journal of Zoology (2024)

Jiaojiao Ma

Gastric cancer is a multifactorial disease, the fourth most common cancer in the world and the second cause of cancer death.Changes in gene expression levels are one of the most important factors in the occurrence of cancer.Gene promoter methylation changes are considered a suitable target for therapeutic strategies.In the present study, the frequency of this epigenetic phenomenon and the expression of CDX1 and CDX2 genes and their relationship with pathological and clinical characteristics of Chinese patients with gastric cancer were investigated.In this study, in order to investigate the promoter methylation of CDX1 and CDX2 genes, one hundred thirty-three tissue samples were analyzed using the Methylation Specific PCR method and in order to investigate gene expression, sixty-one tumor tissue samples and eleven normal tissue samples were analyzed using the Real-Time RT-PCR method.According to the data obtained, there was no significant difference in the promoter methylation results of CDX1 and CDX2 genes in tumor tissue compared to normal tissues adjacent to the tumor and normal controls.Furthermore, changes in the expression of CDX1 and CDX2 genes show a significant relationship with increasing disease stages and lymph vascular and perineural invasions.It was concluded that increased frequency in the promoter methylation of CDX1 genes in patients with gastric cancer compared to control tissues and its relationship with factors that confirm the poor prognosis of the disease cannot be introduced alone as a possible candidate for further studies to confirm the role of a poor prognostic biomarker in gastric cancer.

10.17582/journal.pjz/20230816081639

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Publisher Erratum to: The rationale and potential for using Lactobacillus in the management of periodontitis

The Journal of Microbiology (2022)

Jiaqi Wang Yingman Liu Weiru Wang Jiaojiao Ma Manman Zhang

10.1007/s12275-022-1681-3

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Simulated Galactic Cosmic Radiation Exposure-Induced Mammary Tumorigenesis in ApcMin/+ Mice Coincides with Activation of ERα-ERRα-SPP1 Signaling Axis

Cancers (2024)

Kamendra Kumar Jerry Angdisen Jiaojiao Ma Kamal Datta Albert J. Fornace

Background: Exposure to galactic cosmic radiation (GCR) is a breast cancer risk factor for female astronauts on deep-space missions. However, the specific signaling mechanisms driving GCR-induced breast cancer have not yet been determined. Methods: This study aimed to investigate the role of the estrogen-induced ERα-ERRα-SPP1 signaling axis in relation to mammary tumorigenesis in female ApcMin/+ mice exposed to simulated GCR (GCRsim) at 100–110 days post-exposure. Results: In GCRsim-exposed mice, we observed marked elevations in serum estradiol, increased ductal overgrowth, ERα activation, and upregulation of ERα target genes with pro-tumorigenic functions in mammary tissues that was coupled with a higher mammary tumorigenesis, relative to control. Additionally, the ERα target gene Esrra, which encodes ERRα, was also upregulated along with its oncogenic target gene Spp1, indicating the activation of the ERα-ERRα-SPP1 axis in mouse mammary tissues after GCRsim exposure. Using a human tissue microarray and human breast cancer gene expression analysis, we also highlighted the conserved nature of the ERα-ERRα-SPP1 signaling in human breast cancer development. Conclusions: We identified the ERα-ERRα-SPP1 signaling axis as a potential key mediator in GCR-induced breast cancer with conserved activation in human breast cancer. These findings suggest that targeting this pathway could serve as a potential target for therapeutic intervention to safeguard female astronauts during and after a prolonged outer space mission.

10.3390/cancers16233954

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Controllable Fabrication of Ag Nanoparticles-Coated Silica Core–Shell Microspheres and Its Optical Properties

Journal of Nanoscience and Nanotechnology (2017)

Jiaojiao Ma Qi Zhao Ying Li Jianjun Bao

This paper described a one-step shell growth and extraordinarily facile method for the preparation of Ag nanoparticles-coated silica core–shell microspheres. The Ag nanoparticles could deposit on the silica microspheres to form continuous and compact shell layers at a balanced amount of polyvinyl pyrrolidone after the surface modification of the silica microspheres by (3-Mercaptopropyl) trimethoxysilane. The strong interactions between the thiol groups and Ag nanoparticles make it difficult to peel off the Ag shell from the core microspheres, obtaining extremely stable and homogeneous Ag nanoparticles-coated silica core–shell microspheres. Besides, the coating effect was controlled by varying the content of coupling agent, the type and amount of stabilizing agent, the quantity of silica microspheres as well as the mixing time between silica and silver ammonia solution. In addition, these Ag nanoparticles-coated silica core–shell microspheres were characterized using laser particle size analyzer (LPS), scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The optical properties of the composite microspheres were observed by UV-vis spectroscopy.

Glass microsphere

Surface Modification

Silicon dioxide

10.1166/jnn.2017.13055

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Vertically Aligned Few-Layer Crumpled MoS₂ Hybrid Nanostructure on Porous Ni Foam toward Promising Binder-Free Methanol Electro-Oxidation Application

Energy & Fuels (2021)

Arthi Gopalakrishnan Lignesh Durai Jiaojiao Ma Chang Yi Kong Sushmee Badhulika

MoS2, a two-dimensional nanomaterial analogous to graphene, has interesting catalytic properties that make it suitable for the hydrogen evolution reaction, but reports are scarce on its fuel cell application. Herein, we report a novel vertically aligned crumpled MoS2 nanosheet hybrid nanostructure architecture on porous Ni foam (MoS2/NF-5) via a facile, one-pot hydrothermal synthesis approach. The porous binder-free Ni foam (NF) promotes the uniform growth of ultrathin MoS2 nanosheets, due to its grain boundaries acting as nucleation sites, and reduces the interfacial resistance between MoS2 and substrate. The hybrid nanostructure of spongy nanoparticles decorated over nanosheets morphology provides synergistic effect for rapid charge transfer reaction with short diffusion path and enhances the electrocatalytic active sites. The electrochemical analysis of as-obtained optimized MoS2/NF-5 reveals an outstandingly high electroactive surface area with the presence of both adsorption and diffusion process at the surface, indicating its potential toward a variety of electrochemical applications. The binder-free MoS2/NF-5 displays excellent electro-oxidation of methanol with high current tolerance of 73 mA/cm2, high durability (only 20% loss after 5000 s), and low overpotential (0.3 V) due to the presence of electroactive sites and conductive substrate for facile charge transportation. Hence, this platform of MoS2 morphology directly grown on 3D NF substrate with excellent electrochemical properties can be utilized as a potential binder-free electrode for catalytic and electrochemical applications.

10.1021/acs.energyfuels.1c00957

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Citations (28)

Temporal and spatial distributions, source identification, and health risk assessment of polycyclic aromatic hydrocarbons in PM2.5 from 2016 to 2021 in Shenzhen, China

Environmental Science and Pollution Research (2023)

Jinfeng Fu Jiajia Ji Lan Luo Xiaoheng Li Xiaoxin Zhuang

Health Risk Assessment

Polycyclic aromatic hydrocarbon

Inhalation exposure

10.1007/s11356-023-29686-0

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Commentary concerning the “Measurement, correlation of the solubility and solution thermodynamics of 2-cyanoguanidine in (methanol + water) binary solvent systems from T = (283.15 to 343.15) K”

The Journal of Chemical Thermodynamics (2018)

Jiaojiao Ma Jinhua Liang Hongkun Zhao

Mole fraction

10.1016/j.jct.2018.08.039

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Modeling gray-scale and contrast-enhanced ultrasound in the diagnosis of thyroid lesions

Zhonghua neifenmi daixie zazhi (2013)

Jiaojiao Ma Hong Ding Benhua Xu Feng Mao Yuli Zhu

Objective To investigate the discriminant analysis model of gray-scale ultrasound (GSUS),contrast-enhanced ultrasound (CEUS) and the combination of them in the differential diagnosis of benign and malignant thyroid lesions and the diagnostic values.Methods Ultrasound images of 211 thyroid lesions confirmed by pathology were synthetically reviewed by scoring 5 GSUS indicators including shape (X1),orientation (X2),interior echogenicity (X3),halo sign (X4),and microcalcification (X5),as well as 6 CEUS indicators including relative arrival time of microbubhles in the periphery (X6) and interior (X7),peak periphery (X8) and interior (X9)echogenicity,peripheral ring-enhancement (X10),homogeneity of enhancement (X11).The diagnostic models with their values of GSUS,CEUS and the combination of them were explored by discriminant analysis.Results The discriminant analysis function of GSUS in the diagnosis of thyroid benign and malignant lesions was g1 (X) =0.715 X1+0.276X2 + 1.028X3 +1.197X4 +0.923X5-2.202 with the diagnostic value 86.3％,the discriminant analysis function of CEUS was g2(X) =-0.392X6 +0.541X7-0.117X8 +0.562X9 + 1.173X10 +2.200X11-1.956 with the diagnostic value 89.1％,and the discriminant analysis function of the combination of GSUS and CEUS was g3 (X) =0.418X1 + 0.173X2 + 0.626X3 + 0.558X4 + 0.183X5-0.476X6 + 0.474X7-0.071X8 + 0.399X9 + 0.985X10 +1.639X11-2.530 with the diagnostic value 91.0％.Conclusions GSUS and CEUS were valuable in the differential diagnosis of benign and malignant thyroid lesions,and the combination of GSUS and CEUS was most valuable. Key words: Thyroid ; Ultrasound ; Contrast-enhanced ultrasound ; Diagnostic model

Echogenicity

Thyroid Nodules

Discriminant function analysis

10.3760/cma.j.issn.1000-6699.2013.07.003

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Biological analysis on extractives of bayberry fresh flesh by GC–MS

Saudi Journal of Biological Sciences (2017)

Shengbo Ge Li‐Shu Wang Jiaojiao Ma Shuaicheng Jiang Wanxi Peng

Bayberry has been largely planted in China, and the waste of fresh flesh of bayberry was still abandoned. Therefore, the extractives of fresh flesh of bayberry were studied to further utilize the bio-resources. Through the Foss method, the result shown that ketone, aldehyde, ester and acid compounds were accounted for 1.30, 92.61, 0.54 and 6.09% of the extractives which were extracted from fresh flesh of bayberry by methanol solvents. Aldehyde, bicyclic sesquiterpenes, acid, ester and alcohol compounds accounted for 53.74, 9.95, 28.49, 6.79 and 1.05% of the extractives which were extracted from fresh flesh of bayberry by ethanol solvents. Ketone, aldehyde, carbohydrate, acid and ester compounds accounted for 4.77, 77.95, 12.06, 4.77 and 0.44% of the extractives which were extracted from fresh flesh of bayberry by ethyl acetate solvents. The extractives of fresh flesh of bayberry were rich in rare drug and biomedical activities and the ethanol is more better to extract the fresh flesh of bayberry.

Flesh

10.1016/j.sjbs.2017.09.001

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Citations (16)

Contrast-enhanced ultrasonography for evaluation of cystic renal mass: in comparison to contrast-enhanced CT and conventional ultrasound

Abdominal Radiology (2014)

Li-yun Xue Qing Lü Beijian Huang Jiaojiao Ma Lixia Yan

Contrast-enhanced ultrasound

10.1007/s00261-014-0171-4

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Citations (56)