José Aristeu Fachini Frias

National Research Institute

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Franklin Sarmento da Silva Braga

Universidade Estadual de Campinas (UNICAMP)

Angélica de Fátima de Assunção Braga

Universidade Estadual de Campinas (UNICAMP)

Glória Maria Braga Potério

Hospital de Clínicas da Unicamp

Fernanda Maria Silva Pedro

Marymount University

Derli Conceição Munhoz

Universidade Estadual de Campinas (UNICAMP)

Eunice Sizue Hirata

Universidade Estadual de Campinas (UNICAMP)

Rosa Inês Costa Pereira

Universidade Estadual de Campinas (UNICAMP)

Ricardo Barini

Universidade Estadual de Campinas (UNICAMP)

Angélica Assunção Braga

Universidade Estadual de Campinas (UNICAMP)

Juliana Guarize

European Institute of Oncology

Cooperative Institutions

Universidade Estadual de Campinas (UNICAMP)

Hospital de Clínicas da Unicamp

Novartis (Switzerland)

Sociedade Brasileira de Anestesiologia

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Texas Liver Institute

The University of Texas Health Science Center at San Antonio

Inserm

Novo Nordisk (Denmark)

Hospital Universitario La Paz

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Influência dos Hipnóticos no bloqueio neuromuscular produzido pelo cisatracúrio: emprego da aceleromiografia Influencia de los hipnóticos en el bloqueo neuromuscular producido por el cisatracurio: uso de la aceleromiografía Influence of hypnotics on cisatracurium-induced neuromuscular block: use of acceleromyograhpy

DOAJ (DOAJ: Directory of Open Access Journals) (2013)

Angélica de Fátima de Assunção Braga Franklin Sarmento da Silva Braga Glória Maria Braga Potério José Aristeu Fachini Frias Fernanda Maria Silva Pedro

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Anestesia peridural continua para cesariana em paciente portadora de arterite de Takayasu

Revista de Ciências Médicas (2012)

Angélica de Fátima de Assunção Braga Franklin Sarmento da Silva Braga José Aristeu Fachini Frias Celina Chen Patrícia Okuyama

A melhor tecnica anestesica para pacientes com arterite de Takayasu e controversa. A anestesia regional tem sido questionada por alguns autores, devido ao risco de hipotensao arterial. A anestesia geral e tambem questionada por dificultar a avaliacao da funcao cerebral, que pode estar alterada nestes pacientes, alem das repercussoes na pressao arterial. Relata-se neste estudo o caso de uma paciente de 31 anos, 35 semanas de idade gestacional, portadora de arterite de Takayasu ha 2 anos, em uso de prednisona, submetida a cesariana sob anestesia peridural continua. A cirurgia transcorreu sem alteracoes pressoricas, respiratorias ou de consciencia; foi necessario o uso de metoprolol (3mg EV) para controle da frequencia cardiaca. A tecnica anestesica empregada possibilitou titular doses de anestesicos locais para obtencao de nivel adequado de anestesia necessario para a realizacao de operacao cesariana, com minimo risco de hipotensao arterial. Termos de indexacao : anestesia peridural; arterite de Takayasu; gravidez.

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[Clinical relevance of monitoring the plasma levels of theophylline].

PubMed (1987)

José Aristeu Fachini Frias Antonio J. Carcas Castro Ma López Serrano Alzamora Fm

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Neuromuscular And Cardiovascular Effects Of Pipecuronium. A Comparative Study Between Different Doses.

Scopus (2008)

Angélica F.A. Braga Leandro Yoshioka Franklin Sarmento da Silva Braga Glória Maria Braga Potério José Aristeu Fachini Frias

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Association of lipophilic opioids and hyperbaric bupivacaine in spinal anesthesia for elective cesarean section. Randomized controlled study

Acta Cirúrgica Brasileira (2014)

Angélica de Fátima de Assunção Braga Franklin Sarmento da Silva Braga Eunice Sizue Hirata Rosa Inês Costa Pereira José Aristeu Fachini Frias

To evaluate the efficacy and side-effects of fentanyl and sufentanil combined with hyperbaric spinal bupivacaine in elective cesarean section.A prospective, randomized, double-blind study with 64 term parturients, distributed into 2 groups according to the opioid combined with hyperbaric bupivacaine 0.5% (10mg): GF - fentanyl (25 µg) and GS - sufentanil (5.0 µg). The latency and maximum sensory block level; degree and duration of motor block; duration and quality of analgesia; maternal-fetal repercussions were evaluated. This was an intention-to-treat analysis with a 5% significance level.The latency period, maximum sensory block level, motor block degree and perioperative analgesia were similar in both groups. Motor block and analgesia had a longer duration in the sufentanil group. Maternal adverse effects and neonatal repercussions were similar. The incidence of hypotension was higher in the fentanyl group. In both groups, there was a predominance of patients who were awake and either calm or sleepy.The addition of fentanyl and sufentanil to hyperbaric subarachnoid bupivacaine was shown to be effective for the performance of cesarean section, and safe for the mother and fetus. Analgesia was more prolonged with sufentanil.

Sufentanil

Motor block

10.1590/s0102-86502014001800010

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Anestesia Espinhal com 10 mg de Bupivacaína Hiperbárica Associada a 5 μg de Sufentanil para Cesariana. Estudo de Diferentes Volumes * Spinal Block with 10 mg of Hyperbaric Bupivacaine Associated with 5 µg of Sufentanil For Cesarean Section. Study of Different Volumes

Artigo Científico José Aristeu Fachini Frias Franklin Sarmento Silva Braga

SUMMARY Braga AFA, Frias JAF, Braga FSS, Pinto DRS – Spinal Block with 10 mg of Hyperbaric Bupivacaine Associated with 5 μg of Sufentanil for Cesarean Section. Study of Different Volumes. BACKGROUND AND OBJECTIVES: Several factors affect the ce-phalad dispersion of the anesthetic solution in the subarachnoid spa-ce; among them, physiological changes of pregnancy and the dose and volume of the local anesthetics should be mentioned. The objec-tive of this study was to assess the effectivity and side effects of diffe-rent volumes of the subarachnoid administration of the association of hyperbaric bupivacaine and sufentanil in cesarean sections. METHODS: Forty patients, ASA I and II, undergoing elective cesare-an section under spinal block were divided in two groups, according to the volume of the anesthetic solution: Group I (4 mL) and Group II (3 mL). The association of hyperbaric bupivacaine (10 mg -2 mL) and sufentanil (5 µg -1 mL) was used in both groups. In Group I, 1 mL of NS was added to the solution to achieve the volume of 4 mL. The following parameters were evaluated: latency of the blockade; upper limit of the sensorial blockade; degree of motor blockade; time for re-gression of the motor blockade; total duration of analgesia; maternal side effects; and neonatal repercussions.

Sufentanil

Motor block

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Spinal anesthesia for elective ceasarean section: use of different doses of hyperbaric bupivacaine associated with morphine and clonidine

Acta Cirúrgica Brasileira (2013)

Angélica de Fátima de Assunção Braga José Aristeu Fachini Frias Franklin Sarmento da Silva Braga Rosa Inês Costa Pereira Stella Marys Meirelles Campos Titotto

PURPOSE: To comparatively study the efficacy and maternal and fetal side-effects of two doses of bupivacaine associated with morphine and clonidine, administered by the subarachnoid route for cesarean section. METHODS: The study included 66 pregnant women at term, distributed into two groups. GI: bupivacaine 8.0 mg (1.6mL) + clonidine 75µg (0.5mL) + morphine 100µg (1.0mL) and GII: bupivacaine 10mg (2.0mL) + clonidine 75µg (0.5mL) + morphine 100µg (1.0mL). The following parameters were assessed: onset and maximum level of sensory block; quality of intraoperative and postoperative analgesia; degree and duration of motor block; maternal repercussions and Apgar score. RESULTS: The onset of sensory block, quality of intraoperative analgesia and total duration of analgesia were similar in both groups; maximum extent of sensory block predominated in T4; maximum degree of motor block (Bromage 3); time motor block regression was significantly longer in GII; Hemodynamic, respiratory repercussions, adverse maternal effects and Apgar scores were similar between groups. In both groups, there was a predominance of drowsy or sleeping patients. CONCLUSION: The addition of morphine and clonidine to low doses of hyperbaric bupivacaine produced adequate anesthesia for cesarean section and good postoperative analgesia, without any maternal and fetal repercussions.

Apgar score

10.1590/s0102-86502013000100005

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Incidência de cefaléia após anestesia subaracnóidea e o uso de diferentes tipos e calibres de agulhas

José Aristeu Fachini Frias Angélica de Fátima de Assunção Braga Franklin Sarmento da Silva Braga Glória Maria Braga Potério

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Tropifexor, a highly potent FXR agonist, produces robust and dose-dependent reductions in hepatic fat and serum alanine aminotransferase in patients with fibrotic NASH after 12 weeks of therapy: FLIGHT-FXR Part C interim results

Digestive and Liver Disease (2020)

Kathryn Jean Lucas Patricia López Eric Lawitz Aasim Sheikh Dov Aizenberg

Steatohepatitis

Tolerability

Interim

Alanine aminotransferase

10.1016/j.dld.2019.12.129

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Inﬂuence of Hypnotics on Cisatracurium-induced Neuromuscular Block. Use of Acceleromyograhpy

Brazilian Journal of Anesthesiology (English Edition) (2013)

Angélica de Fátima de Assunção Braga Franklin Sarmento da Silva Braga Glória Maria Braga Potério José Aristeu Fachini Frias Fernanda Maria Silva Pedro

: Different drugs, including hypnotics, may inﬂuence the pharmacodynamic effects of neuromuscular blockers (NMB). The aim of this study was to evaluate the inﬂuence of propofol and etomidate on cisatracurium-induced neuromuscular blockade. We included 60 patients, ASA I and II, undergoing elective surgery under general anesthesia in the study and randomly allocated them into two groups, according to their hypnotic drug: GI (propofol) and GII (etomidate). Patients received intramuscular (IM) midazolam (0.1 mg.kg-1) as premedication and we performed induction with propofol (2.5 mg.kg-1) or etomidate (0.3 mg.kg-1), preceded by fentanyl (250 mg) and followed by cisatracurium (0.1 mg.kg-1). The patients were ventilated with 100% oxygen until obtaining a reduction of 95% or more in the adductor pollicis response amplitude, with subsequent laryngoscopy and tracheal intubation. Neuromuscular function was monitored by acceleromyograhpy. We evaluated the onset of action of cisatracurium, tracheal intubation conditions, and hemodynamic repercussions. The mean time and standard deviations of cisatracurium onset were: GI (86.6 ± 14.3 s) and GII (116.9 ± 11.6 s), with a signiﬁcant difference (p < 0, 0001). Intubation conditions were acceptable in 100% of GI and 53.3% of GII patients (p < 0.0001). Induction of neuromuscular blockade with cisatracurium was faster, with better intubation conditions in patients receiving propofol compared to those receiving etomidate, without hemodynamic repercussions.

Etomidate

Midazolam

Pharmacodynamics

Premedication

Vecuronium bromide

Neuromuscular transmission

10.1016/j.bjane.2012.05.005

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