P. Poblete

ORCID

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Fernando Sierralta

University of Chile

Hugo F. Miranda

University of Chile

Viviana Noriega

Universidad del Desarrollo

Juan Carlos Prieto

Pontificia Universidad Javeriana

Nicolás Aranda

ORCID

Juan Carlos Prieto

Universidad de Alcalá

V. Jorquera

Universidad Andrés Bello

Fernando Nuez Viñals

University of Concepción

Ramón Sotomayor‐Zárate

University of Valparaíso

A. Giuliano

Clínica Alemana

Cooperative Institutions

Clínica Alemana

University of Chile

Hospital Clínico de la Universidad de Chile

Universidad del Desarrollo

Universidad Andrés Bello

ORCID

Universidad del Desarrollo del Estado de Puebla

Pontificia Universidad Católica de Chile

Universidad de Alcalá

Brigham and Women's Hospital

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Spatio‐temporal image correlation (STIC): a new tool for the prenatal screening of congenital heart defects

Ultrasound in Obstetrics and Gynecology (2003)

Fernando Nuez Viñals P. Poblete A. Giuliano

To assess the feasibility and capability of STIC acquisition, performed by a general obstetrician performing antenatal ultrasound, to visualize fetal cardiac structures in women undergoing routine obstetric ultrasound examination, in order to obtain information to confirm normality of the fetal heart during intrauterine life.This was a prospective study of one hundred fetuses with echocardiographically confirmed normal hearts and no extracardiac anomalies with gestational ages ranging between 18 and 37 weeks. A general obstetrician was invited to acquire the STIC volumes. The four-chamber view was obtained as a starting point. A standard 7.5-s acquisition time and 30 degrees angle of acquisition were used and the resulting STIC was stored for later offline analysis by a fetal echocardiologist. For each patient, the stored STIC data were first evaluated by sweeping from the initial acquisition plane, in the caudal direction and then cranially, zooming, slowing or stopping the cardiac motion to visualize views and structures. If a structure or view was rated as inadequate or not identifiable, a multiplanar three-dimensional (3D) examination of the STIC volume was taken in order to try to visualize it adequately. The rates obtained using just the STIC sweeps were compared independently, and then the 3D multiplanar study was added.STIC acquisition was possible in all cases. The mean time required for STIC acquisition was 7.5 min. A complete cardiac examination according to the set criteria was achieved in 94.2% (95% confidence interval (CI), 90-99) of cases. We obtained a 94.2% success rate of visualizing different structures and views of the fetal heart using the STIC sweep alone (95% CI, 90-99) and 96.2% adding 3D multiplanar examination (95% CI, 92-100).STIC acquisition of the fetal heart is feasible with high success rates in visualization of the principal connections. The STIC data acquired by a general obstetrician can subsequently be used by a fetal echocardiologist for prenatal confirmation of normal cardiac structure or exclusion of major cardiac malformations.

Fetal heart

Fetal echocardiography

10.1002/uog.883

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Citations (180)

Isobolographic Antinociception of Nonsteroidal Anti-inflammatory Drugs in Rodent Formalin Orofacial Pain

Pharmaceutical and Biomedical Research (2020)

Viviana Noriega Fernando Sierralta Nicolás Aranda Ramón Sotomayor‐Zárate P. Poblete

Background: Diverse studies suggest that non-steroidal anti-inflammatory drugs (NSAIDs) induce antinociception through the inhibition of cyclooxygenases. Objectives: This study evaluated the effect of NSAIDs in inducing antinociception either alone or in combination in mice formalin orofacial pain. Methods: Male mice were injected intraperitoneally with dexibuprofen, dexketoprofen, diclofenac meloxicam, metamizole and piroxicam. Then from a dose-response curve the ED50 (dose that produce 50% of maximum effect) was obtained from each drug. Results: The administration of NSAIDs produced a dose-dependent antinociception in both phases of the assay with different potency. Then, combinations of the cited NSAIDs were tested and analyzed by isobolographic analysis. The results demonstrate that the nocifensive response induced when dexketoprofen (DEX), the dextrorotatory enantiomer of the S (+) configuration of ketoprofen, was combined with piroxicam, diclofenac, dexibuprofen, metamizole, and meloxicam, was synergistic, either in Phase I or Phase II of the formalin orofacial mice assay. Conclusion: The data demonstrated that the NSAIDs administered alone or in combination produce antinociception. These effects need to be explained by other mechanisms of action of NSAIDs other than the simple inhibition of COXs. The findings may be relevant for the relief of acute or chronic pain such as migraine, post‐herpetic neuralgia and tooth pain.

Meloxicam

Ketoprofen

Diclofenac

ED50

Metamizole

10.18502/pbr.v6i3.4647

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Simple approach to prenatal diagnosis of transposition of the great arteries

Ultrasound in Obstetrics and Gynecology (2006)

Fernando Nuez Viñals R. Ascenzo P. Poblete C. Comas G. Vargas

To analyze the most relevant anomalies, seen in a sequential segmental transverse views approach to imaging the fetal heart, that provide clues to the diagnosis of complete transposition of the great arteries (TGA).We reviewed retrospectively all the cases of isolated TGA diagnosed in our center or submitted for a second opinion through the spatio-temporal image correlation (STIC) telemedicine (TELE-STIC) program. Only transverse cardiac sweeps were obtained. Digital video clips and STIC volumes were reviewed. The abnormal features on four-chamber, five-chamber, three-vessel (3V) and three vessels and trachea (3VT) views were analyzed.The study population consisted of eight fetuses with TGA with normal extracardiac anatomy. The gestational age ranged from 13 to 32 (mean, 23) weeks. The maternal age ranged from 25 to 42 (mean, 32) years. A normal four-chamber view was seen in seven cases. Only one case demonstrated a significant ventricular septal defect. At the level of the five-chamber view a straight course arterial vessel arose from the left ventricle with lateral branches in all fetuses. In the 3V view, the ascending aorta was seen reaching more anteriorly than was the pulmonary artery in six cases. At the level of the 3VT view, two vessels (transverse aortic arch and superior vena cava) rather than three were seen in all cases.Our proposed sequential segmental approach to imaging the fetal heart apparently allows, in five-chamber and 3VT views, clear and confident signs to be detected that aid diagnosis of TGA.

Great vessels

Fetal echocardiography

10.1002/uog.2821

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Citations (35)

Receptors involved in dexketoprofen analgesia in murine visceral pain

Journal of Biosciences (2020)

Viviana Noriega Fernando Sierralta P. Poblete Nicolás Aranda Ramón Sotomayor‐Zárate

Visceral pain

10.1007/s12038-020-00064-z

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Citations (3)

Antinociception induced by rosuvastatin in murine neuropathic pain

Pharmacological Reports (2017)

Hugo F. Miranda Fernando Sierralta Nicolás Aranda P. Poblete Rodrigo L. Castillo

Proinflammatory cytokine

TBARS

10.1016/j.pharep.2017.11.012

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Citations (13)

Synergism between gabapentin–tramadol in experimental diabetic neuropathic pain

Fundamental and Clinical Pharmacology (2018)

Hugo F. Miranda Fernando Sierralta Nicolás Aranda P. Poblete Viviana Noriega

Abstract Neuropathic pain is associated with several conditions such as surgery, cancer, and diabetes and can be induced experimentally. Among the drugs used as monotherapy are gabapentin and tramadol. The purpose of this study was to evaluate the coadministration of gabapentin and tramadol, by isobolographic analysis, in three different algesiometric assays in experimental diabetic neuropathic pain induced by streptozocin in mice. In all the behavioral tests, gabapentin or tramadol produced a dose‐dependent antinociception and their coadministration resulted in a positive interaction. This effect can be explained by principles of multimodal analgesia, whereby the different mechanisms of action of each drug contribute to the combined effect in a supra‐additive manner. The findings of the present study suggest that the combination of gabapentin and tramadol could be a useful strategy for the treatment of pain induced by diabetic neuropathy.

Streptozocin

Diabetic Neuropathy

10.1111/fcp.12400

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Citations (9)

UP.90: Clinical Outcome of Primary Conservative Treatment for High Grade Non-Muscle Invasive Bladder Cancer

Urology (2008)

Mario I. Fernández Marcela Schultz A. Krebs Hugo Bermúdez Gustavo Larach

Conservative Treatment

10.1016/j.urology.2008.08.417

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Citations (0)