Hamad H. Issa

Kaohsiung Medical University

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Tatsuo Higa

University of the Ryukyus

Junichi Tanaka

University of the Ryukyus

Fang‐Rong Chang

Kaohsiung Medical University

Yang‐Chang Wu

China Medical University

Rachmaniar Rachmat

Indonesian Institute of Sciences

Yuliang Yang

Agricultural Biotechnology Research Center, Academia Sinica

Agus Trianto

Diponegoro University

Musri Musman

Syiah Kuala University

Paul J. Scheuer

University of Hawaiʻi at Mānoa

Wesley Y. Yoshida

University of Hawaiʻi at Mānoa

Cooperative Institutions

University of the Ryukyus

Kaohsiung Medical University

University of Hawaiʻi at Mānoa

University of Hawaii System

University of Wisconsin–Madison

Osaka University

National Institute of Water and Atmospheric Research

Kaohsiung Medical University Chung-Ho Memorial Hospital

National Sun Yat-sen University

Institute of Biological Chemistry, Academia Sinica

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Cytotoxic Sesquiterpene Lactones from Pseudoelephantopus spicatus

Journal of Natural Products (2007)

Yuliang Yang Sue-Ming Chang Chin‐Chung Wu Pei‐Wen Hsieh Shu‐Li Chen

Five new sesquiterpene lactones, spicatolides D−H (1−5), along with four known compounds, pitocarphin D (6), 8α-acetoxy-10α-hydroxy-13-O-methylhirsutinolide (7), spicatolide A (8), and 13-O-methylvernojalcanolide 8-O-acetate (9), were isolated from an ethyl acetate extract of the aerial parts of Pseudoelephantopus spicatus. The structures of the new compounds were elucidated on the basis of spectroscopic data interpretation. All of the compounds isolated were evaluated for their cytotoxic effects against five human cancer cell lines. Compounds 1, 3, and 4 showed cytotoxicity (IC50 < 5 µ g/mL) against the Hep3B and MCF-7 cancer cell lines.

Cancer cell lines

10.1021/np070331q

Cite

Citations (15)

Floresolides, new metacyclophane hydroquinone lactones from an ascidian, Aplidium sp

Tetrahedron Letters (2003)

Hamad H. Issa Junichi Tanaka Rachmaniar Rachmat Tatsuo Higa

Hydroquinone

Cyclophane

10.1016/s0040-4039(02)02812-5

Cite

Citations (28)

Polycitorols A and B, New Tricyclic Alkaloids from an Ascidian

Marine Drugs (2005)

Hamad H. Issa Junichi Tanaka Rachmaniar Rachmat Andi Setiawan Agus Trianto

Two new tricyclic alkaloids, polycitorols A (1) and B (2) have been isolated along with the known lepadiformine (3) from a marine ascidian of the family Polycitoridae. The structures of the new compounds were elucidated by analysis of NMR data and comparison with those of 3 and other related compounds [1-5]. Compounds 1 and 2 are closely related to cylindricines A and B, lacking C-4 oxygenation found in cylindricines and having a butyl instead of a hexyl appendage. NOE experiments on compounds 1 and 2 suggested the A/B ring fusion to be cis.

Tricyclic

Appendage

10.3390/md303078

Cite

Citations (24)

Anti-Inflammatory and Cytotoxic Diterpenes from FormosanPolyalthia longifoliavar.pendula

Planta Medica (2006)

Fang‐Rong Chang Tsong‐Long Hwang Yuliang Yang Chia-En Li Chin‐Chung Wu

A new clerodane diterpenoid 16-hydroxycleroda-13-ene-15,16-olide-3-one (1) was isolated from the bark of Polyalthia longifolia var. pendula, along with 23 known compounds and phytosteroids. Among these compounds, 5 - 7, 10, and 24 were obtained for the first time from the family Annonaceae. The structures of the isolated compounds were determined by mass and spectroscopic analysis. The clerodane diterpenoids, 2 - 4, showed significant cytotoxicity towards Hep G2 and Hep 3B hepatoma cell lines. Furthermore, compound 5 exhibited potent anti-inflammatory activity towards formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B (fMLP/CB)-induced superoxide generation by neutrophils with IC50 = 0.60 ± 0.09 μg/mL.

10.1055/s-2006-951691

Cite

Citations (79)

CCDC 193560: Experimental Crystal Structure Determination

The Cambridge Structural Database (2003)

Hamad H. Issa J. Tanaka Rachmaniar Rachmat Toshio Higa

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

Crystal (programming language)

10.5517/cc6hdwy

Cite

Citations (0)

New Sesquiterpene Lactones from the Aerial Parts of Pseudoelephantopus spicatus.

ChemInform (2007)

Hamad H. Issa Sue‐Ming Chang Yuliang Yang Fang‐Rong Chang Yang‐Chang Wu

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

10.1002/chin.200717176

Cite

Citations (0)

Isolation and structure elucidation of new metabolites from coral reef invertebrates

Hamad H. Issa

Marine invertebrates

Isolation

Coral reef organizations

Source

Cite

Citations (0)

New Sesquiterpene Lactones from the Aerial Parts of Pseudoelephantopus spicatus

Chemical and Pharmaceutical Bulletin (2006)

Hamad H. Issa Sue-Ming Chang Yuliang Yang Fang‐Rong Chang Yang‐Chang Wu

Two new sesquiterpene lactones, spicatolide C (1) and spicatocadinanolide A (2), have been isolated along with the known piptocarphol isomers (3, 4) and one eudismane type sesquiterpene (5) from the EtOAc extract of the aerial parts of Pseudoelephantopus spicatus. The structures and the relative stereochemistries of the new metabolites were determined by spectroscopic methods.

10.1248/cpb.54.1599

Cite

Citations (13)

New Polyoxygenated Steroids Exhibiting Reversal of Multidrug Resistance from the Gorgonian Isis hippuris

ChemInform (2002)

Junichi Tanaka Agus Trianto Musri Musman Hamad H. Issa Ikuko I. Ohtani

Abstract For Abstract see ChemInform Abstract in Full Text.

Gorgonian

10.1002/chin.200250164

Cite

Citations (2)

CCDC 182359: Experimental Crystal Structure Determination