Virginio Pietra

Université Joseph Ki-Zerbo

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Jacques Simporé

Université Joseph Ki-Zerbo

Salvatore Pignatelli

University of Bari Aldo Moro

Abdoul Karim Ouattara

Université Joseph Ki-Zerbo

Dorcas Obiri‐Yeboah

University of Cape Coast

Florencia Wendkuuni Djigma

Université Joseph Ki-Zerbo

Francesco Castelli

Azienda Ospedaliera Citta' della Salute e della Scienza di Torino

Théodora Mahoukèdè Zohoncon

Université Joseph Ki-Zerbo

Albert Théophane Yonli

Université Joseph Ki-Zerbo

Lassina Traoré

Institut de Recherche en Sciences de la Santé

Serge Théophile Soubeïga

Institut de Recherche en Sciences de la Santé

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Université Joseph Ki-Zerbo

Institut de Recherche en Sciences de la Santé

University of Brescia

University of Rome Tor Vergata

Centre Hospitalier Universitaire Yalgado Ouédraogo

Joseph Ayo Babalola University

Université Ouaga II

Centre National de la Recherche Scientifique et Technologique

Istituti di Ricovero e Cura a Carattere Scientifico

University of Milan

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Study on the health status of pigeons in Bergamo province [Lombardy]

F. Paterlini Alessandra Gaffuri Chiara Garbarino David M. Broussard Simone Magnino

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<p>Prevention of mother-to-child transmission (PMTCT) of HIV: a review of the achievements and challenges in Burkina-Faso</p>

HIV/AIDS - Research and Palliative Care (2019)

Laure Stella Ghoma Linguissi Tani Sagna Serge Théophile Soubeïga Luc Christian Gwom Céline Nguefeu Nkenfou

Burkina-Faso's HIV/AIDS program is one of the most successful in Africa, with a declining HIV prevalence and treatment outcomes that rival those of developed countries. Prevention of mother-to-child transmission (PMTCT) guidelines in Burkina-Faso, initiated in the year 2000, were revised in 2004, 2006 and 2010. The guideline document has since undergone several stages of improvement, largely based on recommendations from WHO, with adaptations by local experts in the field. Option B+ adopted since August 2014 in Burkina-Faso has enabled maintenance of mothers on longer treatment and increasing their survival and that of their children. Through this review, we describe the achievements and challenges of HIV PMTCT programs in Burkina-Faso.

10.2147/hiv.s204661

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Knowledge, attitudes and practice (KAP) regarding newborn feeding modalities in HIV-infected and HIV-uninfected pregnant women in sub-Saharan Africa: a multicentre study

International Health (2011)

L.R. Tomasoni Massimo Galli Silvia Declich Virginio Pietra Francesco Croce

Exclusive formula feeding, exclusive breastfeeding (EBF) with early weaning or the administration of antiretroviral therapy to lactating mothers and/or to breastfed newborns may lower postnatal HIV transmission. The aim of this study was to assess mothers' knowledge, attitudes and practice (KAP) on lactation in various real-life settings in sub-Saharan Africa. A questionnaire survey investigating KAP with regard to breastfeeding in pregnant women of unknown status (Questionnaire A, 16 items) or HIV-infected women (Questionnaire B, 37 items) was administered. Associations between newborn feeding KAP and demographic, socioeconomic, cultural and obstetric variables were investigated. From January 2007 to January 2008, 2112 pregnant women answered Questionnaire A in Burkina Faso, Cameroon, Chad, Tanzania, Uganda and Zambia. Most women (53.0%) declared EBF as the preferred feeding modality. The practice of strictly defined EBF in previous pregnancies was only 11.4%, which was inversely correlated with education and parity. Questionnaire B was answered by 225 HIV-infected pregnant women in Burkina Faso, Tanzania and Uganda. Knowledge about the lactation-associated risk was associated with previous dead children. Significant variability was observed among collaborating sites. The introduction of fluids other than maternal milk within 6 months of age is common practice in sub-Saharan Africa, requiring intensive health education efforts if strictly defined EBF is to be adopted to decrease HIV postnatal transmission. Significant variation in newborn feeding determinants was observed.

10.1016/j.inhe.2010.11.004

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HIV/AIDS care and international migrations in the rural district of Nanoro, Burkina Faso

Bulletin de la Société de pathologie exotique (2012)

Beatriz del Carmen Autino Silvia Odolini H. Nitiema D. Kiema Alessia Melzani

10.1007/s13149-012-0229-x

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Prevention of mother-to-child transmission of hepatitis B virus in Burkina Faso: Screening, vaccination and evaluation of post-vaccination antibodies against hepatitis B surface antigen in newborns

Journal of Public Health in Africa (2018)

Edwige T. Yelemkoure Albert Théophane Yonli Carla Montesano Abdoul Karim Ouattara Birama Diarra

The low rate of screening for hepatitis B virus (HBV) in pregnant women is a highrisk factor for its vertical transmission. The objectives of this study were: i) to screen pregnant women for HBV infection; ii) vaccinate all children from birth against HBV regardless their mother HBV status; and iii) evaluate after 7 months of birth the level of their AbHBs among babies who received HBV vaccine at birth. Serological markers of HBV (HBsAg, HBeAg, AbHBs, AbHBe, and AbHBc) were determined on venous blood samples from 237 pregnant women and their children using the Abon Biopharm Kit. One hundred and two (102) children received the three doses of the EUVAX B® vaccine respectively at birth, two months and four months of life. Seven months after delivery, venous blood samples were collected from mothers and their children. Antibodies against hepatitis B surface antigen (AbHBs) were measured in vaccinated children using the ELISA Kit AbHBs Quantitative EIA. DNA extraction was performed on samples from HBV-seropositive mothers and their children using the Ribo Virus (HBV Real-TM Qual) Kit and for Real Time PCR, the HBV Real-TM Qual Kit was used. Serological diagnosis in pregnant women revealed 22 (9.28%) hepatitis B surface antigen (HBsAg) positive samples of which 21 were positive for viral DNA by real-time PCR. Among the 22 HBsAg+ women, five (05) transmitted the virus to their children with a vertical transmission rate of 22.73%. A transmission rate of 23.81% (5/21) was found with the PCR method. Analysis of AbHBs levels revealed that 98.31% of the children had an average concentration of 218.07 ± 74.66 IU/L, which is well above the minimum threshold for protection (11 IU/L). This study has confirmed that vertical transmission of HBV is a reality in Burkina Faso and that vaccination at birth would significantly reduce this transmission.

HBeAg

Hepatitis B

Hepatitis B vaccine

10.4081/jphia.2018.816

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Prevalence of HHV-8 Infections Associated with HIV, HBV and HCV in Pregnant Women in Burkina Faso

Journal of Medical Sciences(Faisalabad) (2005)

Jacques Simporé Dénise P. Ilboudo Damintoti Simplice Karou Virginio Pietra Marisa Granato

Hepatitis C

10.3923/jms.2006.93.98

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Outcome and Predictive Factors of Mortality in Hospitalized HIV-Patients in Burkina Faso

Infection (2009)

Nuccia Saleri Susanna Capone Virginio Pietra Giulia De Iaco Veronica Del Punta

10.1007/s15010-008-7406-7

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Human immunodeficiency virus type 1 drug resistance in a subset of mothers and their infants receiving antiretroviral treatment in Ouagadougou, Burkina Faso

Journal of Public Health in Africa (2018)

Serge Théophile Soubeïga Betty Jean Tégwindé Rebeca Compaore Abdoul Karim Ouattara Théodora Mahoukèdè Zohoncon

The emergence of HIV-1 drug resistance (HIVDR) is a public health problem that affects women and children. Local data of HIVDR is critical to improving their care and treatment. So, we investigated HIVDR in mothers and infants receiving antiretroviral therapy (ART) at Saint Camille Hospital of Ouagadougou, Burkina Faso. This study included 50 mothers and 50 infants on ART. CD4 and HIV-1 viral load were determined using FACSCount and Abbott m2000rt respectively. HIVDR was determined in patients with virologic failure using ViroSeq HIV-1 Genotyping System kit on the 3130 Genetic Analyzer. The median age was 37.28 years in mothers and 1.58 year in infants. Sequencing of samples showed subtypes CRF02_AG (55.56%), CRF06_cpx (33.33%) and G (11.11%). M184V was the most frequent and was associated with highlevel resistance to 3TC, FTC, and ABC. Other mutations such as T215F/Y, D67N/E, K70R, and K219Q were associated with intermediate resistance to TDF, AZT, and 3TC. No mutation to LPV/r was detected among mothers and infants. The findings of HIVDR in some mothers and infants suggested the change of treatment for these persons.

HIV drug resistance

Antiretroviral drug

Antiretroviral treatment

Resistance mutation

10.4081/jphia.2018.767

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Effective program against mother‐to‐child transmission of HIV at Saint Camille Medical Centre in Burkina Faso

Journal of Medical Virology (2007)

Jacques Simporé Virginio Pietra Salvatore Pignatelli Damintoti Simplice Karou W.M.C. Nadembega

Abstract The present research was aimed to prevent mother‐to‐child transmission of HIV; to use RT‐PCR in order to detect, 6 months after birth, infected children; and to test the antiretroviral resistance of both children and mothers in order to offer them a suitable therapy. At the Saint Camille Medical Centre, 3,127 pregnant women (aged 15–44 years) accepted to be enrolled in the mother‐to‐child transmission prevention protocol that envisages: (i) Voluntary Counselling and Testing for all the pregnant women; (ii) Antiretroviral therapy for HIV positive pregnant women and for their newborns; (iii) either powdered milk feeding or short breast‐feeding and RT‐PCR test for their children; (iv) finally, pol gene sequencing and antiretroviral resistance identifications among HIV positive mothers and children. Among the patients, 227/3,127 HIV seropositive women were found: 221/227 HIV‐1, 4/227 HIV‐2, and 2/227 mixed HIV infections. The RT‐PCR test allowed the detection of 3/213 (1.4%) HIV infected children: 0/109 (0%) from mothers under ARV therapy and 3/104 (2.8%) from mothers treated with Nevirapine. All children had recombinant HIV‐1 strain (CRF06_CPX) with: minor PR mutations (M36I, K20I) and RT mutations (R211K). Among them, two twins had Non‐Nucleoside Reverse Transcriptase Inhibitor mutation (Y18CY). Both mothers acquired a major PR mutation (V8IV), investigated 6 months after a single‐dose of Nevirapine. Prevention by single‐dose of Nevirapine reduced significantly mother‐to‐child transmission of HIV, but caused many mutations and resistance to antiretroviral drugs. Based on present study the antiretroviral therapy protocol, together with the artificial‐feeding, might represent the ideal strategy to avoid transmission of HIV from mother‐to‐child. J. Med. Virol. 79:873–879, 2007. © 2007 Wiley‐Liss, Inc.

Nevirapine

10.1002/jmv.20913

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Citations (28)

Importance of extending the use of Polymerase chain reaction in the diagnosis of Venereal syphilis in a blood transfusion center in Burkina Faso, West Africa

Pan African Medical Journal (2014)

Abibou Simpore Cyrille Bisseyé Bolni Marius Nagalo Mahamoudou Sanou Yacouba Nébié

Introduction: Due to the existence of a variety of types of non-venereal syphilis caused by the related T. pallidum, regular serological testing such as Rapid Plasma Reagin (RPR) and Chemiluminescent Microparticle Immunoassay Technique (CMIA) are often unable to differentiate venereal syphilis from the non- venereal one, hence, the interest in the use of molecular biology testing for a confirmation diagnosis of syphilis caused by Treponema pallidum subspecies pallidum. Objective: The study is designed to assess the effectiveness of PCR testing and serological methods in the diagnosis of Treponema pallidum subsp pallidum among blood donors in Burkina Faso.

Seroconversion

Rapid plasma reagin

Treponematosis

10.11604/pamj.2014.18.56.3850

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Citations (5)