Masami Fujii

Yamaguchi Prefecture Central Hospital

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Research Trends

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Document Type

Co-Authors

Michiyasu Suzuki

Yamaguchi University

116

Sadahiro Nomura

Yamaguchi University

Hirosuke Fujisawa

Shuto General Hospital

Koji Kajiwara

Chiba University

Shoichi Kato

Tokyo University of Science

Jun Nishimura

High Energy Accelerator Research Organization

Hirochika Imoto

Yamaguchi University

Hideyuki Ishihara

Yamaguchi University

Tatsuo Akimura

Yamaguchi University

Takashi Saito

National Center of Neurology and Psychiatry

Cooperative Institutions

Yamaguchi University

180

The University of Tokyo

154

Osaka University

Tohoku University

Nagoya University

Kyoto University

Kyushu University

University of Occupational and Environmental Health Japan

Institute of Space and Astronautical Science

University of Tsukuba

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The chimeric protein, PEBP2β/CBFβ-SMMHC, disorganizes cytoplasmic stress fibers and inhibits transcriptional activation

Oncogene (1998)

Yuta Tanaka Masami Fujii Keitaro Hayashi Natsuko Chiba Takashi Akaishi

Chimeric gene

Chimera (genetics)

10.1038/sj.onc.1201985

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Citations (19)

Homonymous quadrantanopsia in a case of disproportional hydrocephalus caused by pneumocephalus

Neuro-Ophthalmology (2000)

Sadahiro Nomura Hidemitsu Adachi Masami Fujii

A 29-year-old man with a posterior fossa arachnoid cyst presented with headache. A shunt revision was performed following the diagnosis of a malfunction of a previously inserted cyst-peritoneal shunt. Four days later, he developed right lower homonymous quadrantanopsia with sparing of the temporal crescent of the right eye. MRI revealed pneumocephalus and disproportional hydrocephalus, with enlargement of the occipital horn of the left lateral ventricle. This ventricular enlargement had stretched the optic radiation and caused the visual field defect. Of the fibers associated with right vision passing along the left lateral ventricle, those for peripheral vision of the right eye were located medially. The perimetry of the patient corresponded to the characteristic sparing of the visual field defect when the superior wall of the occipital horn was selectively stretched. The mechanism of enlargement of the occipital horn was thought to be air disturbance of CSF outflow and amplified pulsation of the brain.

Optic radiation

Pneumocephalus

Fourth ventricle

10.1076/noph.24.2.363.7154

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Citations (0)

Initial Trials of a Neurosurgical Navigation System

Japanese Journal of Neurosurgery (1998)

Takafumi Nishizaki Kohichi YOSHIKAWA Makoto Ideguchi Katsumi Harada Koji Kajiwara

脳腫瘍摘出術におけるナビゲーションシステムの有用性と問題点について, 磁場変換式3次元位置測定装置システムを用いて検討した.対象は脳腫瘍19例, 眼窩内腫瘍2例, および難治性てんかん4例である.腫瘍, てんかん焦点の切除範囲の同定に有用で, 特に, 術中脳表に露出していない境界不明瞭の病変に有用であった.基本的な脳外科手術手技を変えることなく, 手術支援が行われた.問題点としては金属による影響に留意しなければならない点であった.正中深部にある腫瘍, 難治性てんかんに対する脳梁離断などでは術中脳の偏位が少ないものの, 半球腫瘍では偏位が避けられないため髄液排出前に脳表の目標点を定め, 術中に経時的に観察する必要がある.

10.7887/jcns.7.177

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Citations (1)

Increased Matrix Metalloproteinase-9 in Blood in Association with Activation of Interleukin-6 after Traumatic Brain Injury: Influence of Hypothermic Therapy

Journal of Neurotrauma (2004)

Eiichi Suehiro Hirosuke Fujisawa Tatsuo Akimura Hideyuki Ishihara Koji Kajiwara

Recent experimental data have shown that levels of matrix metalloproteinase-9 (MMP-9) increase after traumatic brain injury (TBI), degrading components of the basal lamina disrupting the blood–brain barrier. However, the post-traumatic secretion patterns of MMP-9 in humans are unknown. We measured the concentration of MMP-9 in plasma after TBI at the same time as the concentration of interleukin-6 (IL-6) in serum. Levels of MMP-9 and IL-6 in systemic arterial and jugular venous blood from seven patients with TBI were measured on days 0 and 1 post-injury. All patients underwent hypothermia at 32–35°C as soon as possible after admission. Before induction of hypothermia, levels of MMP-9 in arterial and internal jugular venous blood exceeded the normal range. Higher MMP-9 levels were detected in internal jugular venous blood than in arterial blood. After hypothermia had been induced, MMP-9 levels in arterial blood and internal jugular venous blood decreased significantly, to within the normal range. In addition to these changes, a significant correlation was seen between levels of MMP-9 and IL-6 in internal jugular venous blood during the investigation period. These results indicate that MMP-9 is elevated in patients with acute TBI, and may play an important role in traumatic brain damage. The elevation of MMP-9 is associated with inflammatory events following TBI. Hypothermic intervention may suppress the elevation of MMP-9 with suppression of the inflammatory response, affording neuroprotection in TBI.

Venous blood

Arterial blood

10.1089/0897715042664957

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Citations (16)

An Angiographically Occult Arteriovenous Malformation in the Medial Parietal Lobe Presenting as Seizures of Medial Temporal Lobe Origin

Epilepsia (1999)

Masami Fujii Tatsuo Akimura Satoshi Ozaki Shoichi Kato Haruhide Ito

Summary: We present an unusual case of a patient who was diagnosed with temporal lobe epilepsy and whose seizures were reduced markedly after excision of an angiographically occult arteriovenous malformation (AVM) located in the left medial parietal lobe. A 38‐year‐old man had complex partial seizures characterized by motionless staring with oroalimentary and behavioral automatisms since the age of 15 years. Magnetic resonance imaging (MRI) demonstrated a small lesion extending from the left posterior cingulate gyrus to the precuneus. There was no MRI evidence of mesial temporal sclerosis. Intracranial EEG recordings showed ictal onset from the left medial parietal lobe propagating to the medial temporal lobes. Clinical signs appeared when these discharges reached the temporal lobes. After excision of the lesion (which was histologically confirmed as an AVM), together with the marginal cortex, seizures were reduced significantly. Careful diagnostic evaluation of lesions such as the this one may reveal an epileptogenic lesion (zone) far from the region where scalp ictal discharges seem to arise. In our case, we hypothesize that false localization was due to propagation of ictal discharges from the parietal focus through the limbic system.

Arteriovenous malformation

Parietal lobe

Occult

10.1111/j.1528-1157.1999.tb00722.x

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Citations (9)

Energy Determination for RUNJOB Experiment

A.V. Apanasenko V.A. Beresovskaya Masami Fujii V. I. Galkin M. Hareyama

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Citations (0)

Cholecystokinin antagonistic activities of loxiglumide.

PubMed (1997)

K Wakatsuki T. Saito M. Saeki Kiyofumi Ninomiya Hiroshi Kasai

Cholecystokinin (CCK) antagonistic activities of loxiglumide ((+/-)-4-(3,4-dichlorobenzamido)-N-(3-methoxypropyl)-N-pentylgl utaramic acid, CR1505, CAS 107097-80-3) were investigated in the gastrointestine and gallbladder in vivo. Intravenous administration of loxiglumide antagonized the CCK-induced reduction of gastric emptying in rats, acceleration of intestinal transport in mice, increase in ileal motility in rabbits, gallbladder contraction in guinea pigs and acceleration of gallbladder emptying in mice. Orally administered loxiglumide also antagonized the CCK-induced gallbladder emptying in mice. Furthermore, egg yolk-stimulated gallbladder emptying in mice was also inhibited by loxiglumide, indicating that this agent antagonizes not only exogenous but also endogenous CCK. These results demonstrate that loxiglumide is an intravenously and orally effective, potent CCK antagonist.

Proglumide

Gastrointestinal hormone

Source

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Citations (2)

Recurrence of myocardial infarction related to different vessels in a patient with diffuse coronary artery spasm without underlying severe organic stenosis

Clinical Cardiology (1988)

Kiyoshi Takashiba Yasuo Matsuda Y Hamada Hiroshi Ohno Eiji Hyakuna

Abstract A 59‐year‐old man had a first myocardial infarction in the right coronary artery, followed by an another infarction in the left anterior descending coronary artery. Coronary thrombolysis for both occasions of acute myocardial infarction was successfully performed without severe residual stenosis. In the chronic phase after the second myocardial infarction, ergonovine test showed diffuse coronary artery spasm. The etiology of myocardial infarction is briefly discussed.

10.1002/clc.4960110413

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Citations (12)

Temporal Subtraction Method for Lung Nodule Detection on Successive Thoracic CT Soft-Copy Images

Radiology (2013)

Takatoshi Aoki Seiichi Murakami Hyoung Seop Kim Masami Fujii Hiroyuki Takahashi

Purpose To assess the effects of a new computed tomographic (CT) temporal subtraction (TS) method on radiologist performance in lung nodule detection on thin-section CT images. Materials and Methods The institutional review board approved this study, and the informed consent requirement was waived. Fifty pairs (current and previous CT images) of standard-dose 2-mm thin-section CT images and corresponding CT TS images were used for an observer performance study. Two thoracic radiologists identified 30 nodules ranging in size from 5 to 19 mm, and these nodules served as the reference standard of actionable nodules (noncalcified nodules larger than 4 mm). Eight radiologists (four attending radiologists, four radiology residents) participated in this observer study. Ratings and locations of lesions determined by observers were used to assess the significance of differences between radiologists’ performances without and with the CT TS images in jacknife free-response receiver operating characteristics analysis. Results Average figure of merit values increased significantly for all radiologists (from 0.838 without CT TS images to 0.894 with CT TS images [P = .033]). Average sensitivity for detection of actionable nodules was improved from 73.4% to 83.4%, with a false-positive rate of 0.15 per case, by using CT TS images. The reading time with CT TS images was not significantly different from that without. Conclusion The novel CT TS method would increase observer performance for lung nodule detection without considerably extending the reading time. © RSNA, 2013

Nodule (geology)

Subtraction

10.1148/radiol.13130460

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Citations (28)

Brain Metastasis of Testicular Tumor with Massive Hemorrhage

Neurologia medico-chirurgica (1991)

Takafumi Nishizaki Tetsuji Orita Mitsuru Tsuha Y Wakuta Masami Fujii

The authors report two cases of brain metastasis from testicular tumor with massive, sudden intratumoral hemorrhage. In both cases, the hemorrhage occurred during the 1st admission day and carried a high risk of fatality. Early, aggressive surgical removal is advisable before general deterioration. Postoperative chemotherapy with an agent different from the one applied to primary lesion is also recommended because of drug tolerance.

Testicular tumor

Brain hemorrhage

Brain tumor

10.2176/nmc.31.586

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Citations (9)