Pin-Yuan Chen

Chang Gung Memorial Hospital

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Hsiao-Yean Chiu

National Yang Ming Chiao Tung University

Kuo‐Chen Wei

Chang Gung University

Hsiao‐Yean Chiu

Taipei Medical University

Ko‐Ting Chen

Chang Gung Memorial Hospital

Yin-Cheng Huang

Chang Gung University

Hui‐Chuan Huang

Taipei Medical University

Pei-Shan Tsai

Taipei Medical University

Chiung-Yin Huang

Linkou Chang Gung Memorial Hospital

Ning‐Hung Chen

Chang Gung University

Ya-Jui Lin

Linkou Chang Gung Memorial Hospital

Cooperative Institutions

Chang Gung University

Taipei Medical University

Chang Gung Memorial Hospital

Linkou Chang Gung Memorial Hospital

National Health Research Institutes

National Yang Ming Chiao Tung University

Memorial Hospital of South Bend

National Taiwan University

Taipei Medical University Hospital

National Cheng Kung University

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Trajectories of Sleep and Its Predictors in the First Year Following Traumatic Brain Injury

Journal of Head Trauma Rehabilitation (2014)

Pin-Yuan Chen Pei-Shan Tsai Ning‐Hung Chen Li-Pang Chaung Cheng‐Chi Lee

Objectives: To examine how sleep patterns change over the first year following traumatic brain injury (TBI) and to determine whether specific demographic and disease characteristics predict the trajectories of sleep. Design: Prospective study. Participants: Fifty-three patients with first-ever mild to severe TBI. Main Measurements: Sleep measured by actigraphy for 7 consecutive days in the first, third, sixth, and twelfth months following TBI: Chinese versions of Beck Anxiety Inventory and Beck Depression Inventory-II (CBDI-II) measured at the same time points. Data were analyzed with a linear mixed model. Results: Sleep efficiency (the ratio of sleep time to the total time spent in bed) showed a significant upward trend during the study period. Scores on the Chinese version of the Beck Anxiety Inventory and the CBDI-II as well as the use of analgesics significantly predicted the slope of change in sleep efficiency over time. Conclusions: Poor sleep efficiency is a common symptom in the first year among patients with first-ever TBI. Healthcare providers should consider both mental health and pain issues when dealing with sleep complaints in patients with TBI.

Beck Anxiety Inventory

Sleep

Depression

10.1097/htr.0000000000000086

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Citations (18)

Endodermal cyst presenting as a prenatally diagnosed large intracranial cyst

Journal of Neurosurgery Pediatrics (2007)

Pin-Yuan Chen Chieh‐Tsai Wu Tai‐Ngar Lui Shih‐Ming Jung

Endodermal cysts of the central nervous system are unusual lesions. Most reported cysts develop in the spinal canal, whereas others, which occur intracranially, are usually located in the posterior fossa. Although endodermal cysts are considered congenital, a prenatal diagnosis has not been reported. In this report the authors present an extremely rare case of a large intracranial endodermal cyst detected prenatally and treated successfully after birth.

10.3171/ped.2007.106.6.506

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Citations (14)

A complication of recurrent artery of Heubner infarction after resection of a giant thrombotic aneurysm in the anterior cerebral artery A2 segment: case report

Journal of Surgical Case Reports (2024)

Kuan-Hao Fu Pin-Yuan Chen Jiun‐Lin Yan

Abstract Giant thrombotic aneurysms of the anterior cerebral artery (ACA) are rare and pose significant challenges due to their variable clinical presentations. While complications following surgical interventions for these aneurysms are known, they have not been fully characterized. We present a novel case of postoperative infarction in the recurrent artery of Heubner (RAH) following resection of a thrombotic giant aneurysm in the ACA. A 53-year-old man with no prior systemic illnesses presented with progressive weakness in his left hand and foot, along with slurred speech. Imaging studies revealed a giant thrombotic aneurysm in the proximal A2 segment of the right ACA, which was completely occluded. Additionally, a chronic infarction was identified in the territory of the right ACA. The patient underwent successful surgical resection of the aneurysm. However, he subsequently developed an infarction in the RAH territory, a complication rarely reported in the literature. This case highlights the importance of comprehensive preoperative evaluation and underscores the need to anticipate and manage potential complications following surgery.

Anterior cerebral artery

10.1093/jscr/rjae736

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A Meta-analysis of Dynamic Prevalence of Cognitive Deficits in the Acute, Subacute, and Chronic Phases After Traumatic Brain Injury

Journal of Neuroscience Nursing (2021)

Ying-Chieh Tsai Chin-Jung Liu Hui‐Chuan Huang Jiann-Her Lin Pin-Yuan Chen

ABSTRACT BACKGROUND: Reports regarding prevalence of post–traumatic brain injury (TBI) cognitive deficits were inconsistent. We aimed to synthesize the prevalence of cognitive deficits after TBI in the acute, subacute, and chronic phases. METHODS: PubMed, EMBASE, and ProQuest Dissertations and Theses A&I databases were searched from the inception to April 27, 2020. Studies with prospective, retrospective, and cross-sectional designs reporting the prevalence of cognitive deficits after TBI in adults were included. RESULTS: A total of 15 articles were included for prevalence estimation. The pooled prevalence of memory and attention deficits after mild TBI was 31% and 20% in the acute phase and 26% and 18% in the subacute phase, respectively, and 49% and 54% in the subacute phase and 21% and 50% in the chronic phase after moderate-to-severe TBI. The overall prevalence of information processing speed deficits after mild TBI in the acute and subacute phases was 21% and 17%, respectively, and 57% in the chronic phase after moderate-to-severe TBI. The overall prevalence of executive dysfunction in the subacute and chronic phases was 48% and 38%, respectively, after moderate-to-severe TBI. CONCLUSION: Cognitive deficits are prevalent in the acute to chronic phases after TBI. Healthcare providers should design effective intervention targeting cognitive impairment after TBI as early as possible.

10.1097/jnn.0000000000000570

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Diagnostic accuracy of the Berlin questionnaire, STOP-BANG, STOP, and Epworth sleepiness scale in detecting obstructive sleep apnea: A bivariate meta-analysis

Sleep Medicine Reviews (2016)

Hsiao‐Yean Chiu Pin-Yuan Chen Li‐Pang Chuang Ning‐Hung Chen Yu‐Kang Tu

Epworth Sleepiness Scale

Diagnostic odds ratio

Respiratory disturbance index

PsycINFO

Apnea–hypopnea index

10.1016/j.smrv.2016.10.004

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Citations (536)

Diagnostic meta-analysis of the Pediatric Sleep Questionnaire, OSA-18, and pulse oximetry in detecting pediatric obstructive sleep apnea syndrome

Sleep Medicine Reviews (2020)

Chia-Rung Wu Yu‐Kang Tu Li‐Pang Chuang Christopher J. Gordon Ning‐Hung Chen

Pulse Oximetry

Sleep

10.1016/j.smrv.2020.101355

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Citations (46)

A Feasibility Randomized Controlled Crossover Trial of Home-Based Warm Footbath to Improve Sleep in the Chronic Phase of Traumatic Brain Injury

Journal of Neuroscience Nursing (2017)

Hsiao-Yean Chiu En-Yuan Lin Hsiao-Ting Chiu Pin-Yuan Chen

Sleep disturbance is a common complaint after traumatic brain injury (TBI). The aim of this study was to examine the effects of a home-based warm footbath intervention on sleep in patients with TBI.This was a randomized controlled crossover study, and 23 adults with TBI were recruited and randomized to receive first a 30-minute, 41°C warm footbath and then a usual care, or vice versa, with each lasting 3 days and separated by a 3-day washout. Sleep efficiency, sleep onset latency (SOL), total sleep time, and wake after sleep onset (WASO) were assessed by actigraphy.We found that home-based warm footbath significantly had a reduced SOL (difference, -5.11 minutes) and a suppressed WASO (difference, -2.57 minutes) compared with those of usual care, but not in sleep efficiency and total sleep time. No adverse effect was reported.This study suggested that home-based warm footbath is practical and effective in relieving post-TBI sleep disturbances, particular in SOL and WASO. Nurses can use home-based warm footbath as an effective intervention for management of sleep disturbances after TBI.

Crossover study

Sleep

10.1097/jnn.0000000000000325

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Associations between sleep duration and suicidality in adolescents: A systematic review and dose–response meta-analysis

Sleep Medicine Reviews (2018)

Hsiao-Yean Chiu Hsin‐Chien Lee Pin-Yuan Chen Ying-Fan Lai Yu‐Kang Tu

Sleep

10.1016/j.smrv.2018.07.003

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Citations (133)

Focused Ultrasound Enhances Central Nervous System Delivery of Bevacizumab for Malignant Glioma Treatment

Radiology (2016)

Hao-Li Liu Po‐Hung Hsu Chung‐Yin Lin Chiun-Wei Huang Wen-Yen Chai

Purpose To demonstrate that magnetic resonance (MR) imaging-monitored transcranial focused ultrasound can enhance the delivery of the antiangiogenic monoclonal antibody bevacizumab into the central nervous system (CNS) for glioblastoma multiforme (GBM) treatment. Materials and Methods All animal experiments were approved by the animal committee and adhered to experimental animal care guidelines. Transcranial focused ultrasound exposure in the presence of microbubbles was used to open the blood-brain barrier (BBB) to enhance bevacizumab penetration into the CNS in healthy and glioma-bearing mice. Bevacizumab concentration was quantitated with high-performance liquid chromatography, and Western blot testing was performed to confirm the specific biologic form in the CNS. Penetration of bevacizumab into brain tissue was estimated in vivo by means of contrast material-enhanced MR imaging and quantitative gallium 68 ((68)Ga)-bevacizumab micro-positron emission tomography, and glioma progression was longitudinally followed with T2-weighted MR imaging. Hematoxylin-eosin staining and cluster of differentiation 31 immunostaining were used to assess morphologic changes and vascular inhibition at histologic examination. The two-tailed Student t test and the Mantel-Cox log-rank test were used for statistical analyses, with a significance level of .05. Results Focused ultrasound significantly enhanced bevacizumab penetration into the CNS by 5.7- to 56.7-fold compared with that in nonexposed brain (both P < .0001). Contrast-enhanced MR imaging indexes correlated with bevacizumab concentration (r = 0.748-0.857) in vivo. Focused ultrasound-enhanced bevacizumab delivery significantly retarded glioma progression, with a significantly increased median survival (median increase in survival time = 135% in the group treated with bevacizumab and focused ultrasound, P < .0001; as compared with 48% in the group treated with bevacizumab alone, P = .0002). Conclusion Focused ultrasound-enhanced bevacizumab delivery can provide an antivascularization normalization effect to suppress glioma. (©) RSNA, 2016 Online supplemental material is available for this article.

Focused Ultrasound

10.1148/radiol.2016152444

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Citations (129)

A Programmable High-Voltage Compliance Neural Stimulator for Deep Brain Stimulation in Vivo

Sensors (2015)

Cihun‐Siyong Alex Gong Hsin‐Yi Lai Sy-Han Huang Yu‐Chun Lo Nicole Lee

Deep brain stimulation (DBS) is one of the most effective therapies for movement and other disorders. The DBS neurosurgical procedure involves the implantation of a DBS device and a battery-operated neurotransmitter, which delivers electrical impulses to treatment targets through implanted electrodes. The DBS modulates the neuronal activities in the brain nucleus for improving physiological responses as long as an electric discharge above the stimulation threshold can be achieved. In an effort to improve the performance of an implanted DBS device, the device size, implementation cost, and power efficiency are among the most important DBS device design aspects. This study aims to present preliminary research results of an efficient stimulator, with emphasis on conversion efficiency. The prototype stimulator features high-voltage compliance, implemented with only a standard semiconductor process, without the use of extra masks in the foundry through our proposed circuit structure. The results of animal experiments, including evaluation of evoked responses induced by thalamic electrical stimuli with our fabricated chip, were shown to demonstrate the proof of concept of our design.

10.3390/s150612700

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Citations (11)