Majid Mahsa

Shahrekord University of Medical Sciences

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Nader Bagheri

Shahrekord University of Medical Sciences

Hedayatollah Shirzad

Shahrekord University of Medical Sciences

Ghorbanali Rahimian

Shahrekord University of Medical Sciences

Marzieh Sadeghiani

Shahrekord University of Medical Sciences

Mohammedhadi Shafigh

Shahrekord University of Medical Sciences

Morteza Hashemzadeh Chaleshtori

Azarbaijan Shahid Madani University

Heshmat Shahi

Shahid Beheshti University of Medical Sciences

Somayeh Reiisi

Shahrekord University

Abdolmajid Taheri

Shahrekord University of Medical Sciences

Sogra Soleiman

Shahrekord University of Medical Sciences

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Shahrekord University of Medical Sciences

Shahrekord University

Isfahan University of Medical Sciences

Tehran University of Medical Sciences

Kharazmi University

Planta

Iran University of Medical Sciences

National Institute of Genetic Engineering and Biotechnology

University of Newcastle Australia

Islamic Azad University of Shahrekord

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EXPRESSION OF IL-18 CYTOKINE MRNA IN GASTRIC MUCOSA TISSUE OF PATIENTS WITH H. PYLORI INFECTION IN CHAHAR MAHAL AND BAKHTIARI

ISMJ (2014)

Nader Bagheri Ghorbanali Rahimian Loghman Salimzadeh Afshin Taghikhani Majid Mahsa

Background: H. pylori infection is associated with gastritis and marked infiltration of the gastric mucosa by inflammatory cells secreting of several cytokines that contribute to maintain and expand the local inflammation. Different clinical expressions of the infection may reflect different patterns of cytokine expression. Interleukin (IL)-1β, tumor necrosis factor (TNF)-α, IL-17, IL-23, and IL-18 have been reported to be involved in H. pylori-induced gastric mucosal inflammation, but the details and relation to different patterns of inflammation remain unclear. Materials and Methods: Analysis of IL-18 RNA transcripts was performed by real-time PCR. Total RNA was extracted from gastric biopsies of 56 H. pylori-infected patients, 50 H. pylori-negative patients with gastritis, by biozol reagent according to the manufacturer's instructions. CDNA was synthesized from 1 mg of total RNA using First Strand cDNA Synthesis Kit (fermentas) and 3 μL cDNA was amplified by PCR using the 2x Rotor-Gene Probe PCR Master Mix (QIAGEN) and specific primers for each cytokine and β-actin. Results: IL-18 mRNA expression was significantly increased in biopsies of H. pylori-infected patients compared to H. pylori-uninfected individuals. Conclusion: IL-18 may play an important role in the inflammatory response and promoting gastric Th1 responses to H. pylori colonization, and may ultimately influence the outcome of H. pylori-associated diseases that arise within the context of gastritis.

Proinflammatory cytokine

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Comparison of the value of multidetector-row computed tomography in diagnosis of biliary obstruction reasons with the results obtained from invasive procedures

Journal of Shahrekord University of Medical Sciences (2015)

Abdolmajid Taheri Morteza Tahmasbi Mohammad-Ali Dayani Majid Mahsa Sogra Soleiman

Medical journal

Multidetector computed tomography

Value (mathematics)

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cag Pathogenicity island-dependent upregulation of matrix metalloproteinase-7 in infected patients with Helicobacter pylori

Journal of Immunoassay and Immunochemistry (2017)

Marzieh Sadeghiani Nader Bagheri Heshmat Shahi Somayeh Reiisi Ghorbanali Rahimian

Helicobacter pylori (H. pylori) infection has been involved in the pathogenesis of most important gastroduodenal diseases. Matrix metalloproteinases (MMPs) are a large family of zincendopeptidases which play important roles in degradation of extracellular matrix (ECM) and various inflammatory diseases. Therefore, we examined MMP-7 mRNA levels in the gastric mucosa of patients with H. pylori infection and evaluated the effects of virulence factors, such as vacA (vacuolating cytotoxin A) and cagA (cytotoxin-associated gene), in H. pylori-infected patients upon the MMP-7 mRNA mucosal levels. We also determined the correlation between mucosal MMP-7 mRNA levels and the types of disease. Total RNA was extracted from gastric biopsies of 50 H. pylori-infected patients and 50 uninfected individuals. Mucosal MMP-7 mRNA expression level in H. pylori-infected and non-infected gastric biopsies was determined by real-time polymerase chain reaction (PCR). The presences of cagA and vacA virulence factors was evaluated using PCR. MMP-7 expression was significantly higher in biopsies of patients infected with H .pylori compared to uninfected individuals. In addition, mucosal MMP-7 mRNA expression in H. pylori-infected patients significantly associated with the cagA status and the types of disease. Our results suggest that MMP-7 might be involved in the pathogenesis of H. pylori. Peptic ulcer was associated with cag pathogenicity island-dependent MMP-7 upregulation.

CagA

Pathogenesis

Pathogenicity island

10.1080/15321819.2017.1351372

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Correlation between expression of MMP-9 and MMP-3 in Helicobacter pylori infected patients with different gastroduodenal diseases

Arab Journal of Gastroenterology (2018)

Nader Bagheri Marzieh Sadeghiani Ghorbanali Rahimian Majid Mahsa Mohammedhadi Shafigh

CagA

Pathogenesis

10.1016/j.ajg.2018.11.001

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PREVALENCE AND ASSOCIATION OF HELICOBACTER PYLORI INFECTION WITH GASTROINTESTINAL DISEASE

Majallah-i bihdāsht-i Īrān (2014)

Marzieh Sadeghiani Heshmat Shahi Somayeh Reiisi Nader Bagheri Mohammad Hadi. Shafigh Ardestani

Helicobacter Infections

Gastrointestinal disease

Helicobacter

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Prediction of coronary atherosclerotic disease with liver transaminase level

Liver International (2007)

Peyman Adibi Masoumeh Sadeghi Majid Mahsa Golnaz Rozati Masood Mohseni

Abstract Background/Aims: Recent studies have shown that liver transaminases are associated with components of the metabolic syndrome including central obesity, type 2 diabetes, dyslipidaemia and high blood pressure, but their direct influence on coronary atherosclerosis has not been investigated before. We conducted this study to evaluate the predictive value of liver transaminases for angiography‐documented coronary atherosclerosis in patients with coronary heart disease. Methods: Six hundred and thirty consecutive patients with suspicious coronary artery disease (CAD) who were candidates for coronary angiography were enrolled. In addition to coronary angiography, measurements of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) concentrations, C‐reactive protein (CRP) level and assessment of the traits of the metabolic syndrome were performed in all patients. Results: ALT and ALT/AST ratios were significantly correlated with angiographic atherosclerosis score in women ( r =0.17 and 0.24 respectively). Logistic regression analysis showed that the ALT/AST ratio in women could predict severe CAD [odds ratio (OR) 3.93, 95% confidence interval (CI) 1.76–8.76]. After adjustment for components of the metabolic syndrome and CRP concentration, the OR remained significant (4.00 [1.76–9.14]). Although significant in univariate analysis, neither ALT (OR 0.98, 95% CI 0.77–1.15) nor AST (OR 0.99, 95% CI 0.72–1.22) could predict severe CAD in men. Conclusion: An elevated ALT/AST ratio in women predicts coronary atherosclerosis independently of the metabolic syndrome and serum CRP concentration, and should warrant further diagnostic and therapeutic interventions.

Aspartate transaminase

Coronary atherosclerosis

Univariate analysis

10.1111/j.1478-3231.2007.01545.x

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Citations (43)