K. Taranath Shetty

M S Ramaiah University of Applied Sciences

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Rita Christopher

National Institute of Mental Health and Neurosciences

S. V. Suresh Babu

National Institute of Mental Health and Neurosciences

Mallikarjun Badadani

National Institute of Mental Health and Neurosciences

Seetharamaiah Chittiprol

Memorial Healthcare System

S. S. Agarwal

Gandhi Medical College & Hospital

S.C. Guru

National Institute of Mental Health and Neurosciences

Bangalore N. Gangadhar

National Institute of Mental Health and Neurosciences

Shashank Nagendra

University of Calgary

Harish C. Pant

National Institute of Neurological Disorders and Stroke

M. N. Subhash

Vaidyaratnam P.S. Varier Ayurveda College

Cooperative Institutions

National Institute of Mental Health and Neurosciences

National Institutes of Health

National Institute of Neurological Disorders and Stroke

Bangalore University

JSS Academy of Higher Education and Research

National Institute of Mental Health

All India Institute of Medical Sciences

nView Medical (United States)

JSS Medical College and Hospital

Institute of Medical Sciences

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Viral antibodies in recent onset, nonorganic psychoses: Correspondence with symptomatic severity

Biological Psychiatry (1994)

S G Srikanth Vasanthapuram Ravi K.Shenoy Poornima K. Taranath Shetty Bangalore N. Gangadhar

Subacute sclerosing panencephalitis

Viral encephalitis

Cytomegalovirus

10.1016/0006-3223(94)90615-7

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Citations (38)

A specific colorimetric assay for Dapsone in biological fluids

Indian Journal of Clinical Biochemistry (1990)

K. Taranath Shetty Pradnya Naik P. R. Mahadevan

Dapsone

Biological fluids

10.1007/bf02873496

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Citations (8)

Longitudinal study of β2-microglobulin abnormalities in schizophrenia

International Immunopharmacology (2009)

Seetharamaiah Chittiprol Ganesan Venkatasubramanian Narendran Neelakantachar Naveen A. Reddy K. Taranath Shetty

Pathogenesis

10.1016/j.intimp.2009.07.002

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Citations (5)

Dinitrophenyl derivatization of imino acids, spectral characteristics and HPLC analysis: application in urinary peptide-derived hydroxyproline and proline assay

Annals of Clinical Biochemistry International Journal of Laboratory Medicine (2007)

Mallikarjun Badadani S. V. Suresh Babu K. Taranath Shetty

Background: Assay of urinary imino acids, in particular peptide derived, is of immense utility in diagnosis of collagen-related disorders. The often-used methods for hydrolysis of urinary peptides need a long time and are cumbersome, hence the need for relatively simpler, but effective methods. Methods: The method described, based on alkaline hydrolysis by autoclaving for 60 min followed by pre-column dinitrophenyl (DNP) derivatization and high-performance liquid chromatography (HPLC) analysis, demonstrates the complete hydrolysis and stability of urinary peptide derived imino acids. Results: DNP derivatives of both imino acids had identical λ max (380 nm) with molar &epsi; of 28.224 x 10 3 and 17.036 x 10 3 , respectively, for hydroxyproline (Hyp) and proline (Pro). HPLC run, extending up to 18 min, resolved major components of collagen products, namely Hyp, Hyl, Gly, Pro and Lys, with retention times of 6.5, 9.8, 10.5, 11.2 and 12.55 min, respectively. The assay method conformed to linear response for individual amino acid concentrations of 0.5-4.0 nmol per injection, with goodness of fit ( r 2 value) 0.99 for both Hyp and Pro, and detection limit of 0.05-4.0 nmol of DNP derivatives. The recovery of Pro and Hyp, when spiked with urine prior to hydrolysis, were found to be 95% and 92%, respectively. Conclusion: Alkaline hydrolysis by autoclaving and DNP derivatization of imino acids followed by HPLC provides a method for the analysis of peptide-derived Hyp and Pro in urine. Hence, it is of utility to study collagen disorders.

Hydroxyproline

Imino acid

O-Phthalaldehyde

Alkaline hydrolysis

10.1258/000456307780118226

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Citations (6)

Inhibition of neuronal cyclin-dependent kinase-5 by staurosporine and purine analogs is independent of activation by munc-18

Neurochemical Research (1996)

Veeranna K. Taranath Shetty Niranjana D. Amin Philip Grant R. Wayne Albers

Staurosporine

Cyclin-dependent kinase 5

Immunoprecipitation

10.1007/bf02527763

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Citations (30)

β2-Microglobulin abnormalities in antipsychotic-naïve schizophrenia: Evidence for immune pathogenesis

Brain Behavior and Immunity (2008)

Seetharamaiah Chittiprol Ganesan Venkatasubramanian Narendran Neelakantachar Naveen Allha K. Taranath Shetty

Pathogenesis

Beta-2 microglobulin

10.1016/j.bbi.2008.08.007

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Citations (11)

Sweat osmolality in Down's syndrome and cystic fibrosis in an Indian population.

BMJ (1987)

H H Geetha K. Taranath Shetty

PI blockers who require a calcium antagonist for the treatment of angina are prescribed one that has no effect on cardiac conducting tissue.

10.1136/bmj.294.6565.156

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Citations (4)

Erythrocyte lipids in alcohol dependence.

PubMed (1988)

Sanjeev Jain K. Taranath Shetty Rajat Ray N. Janakiramaiah

L'augmentation du rapport erythrocytaire cholesterol/phospholipides peut etre consideree comme l'une des modifications biochimiques associees entrainant une modification des fonctions membranaires associees a la tolerance a l'ethanol et sa dependance. La modification des taux des phospholipides et du cholesterol dans les hematies des alcooliques se produit sans modification de la composition des lipides plasmatiques

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Diazepam- and chlordiazepoxide-mediated increases in erythrocyte aldehyde dehydrogenase activity and its possible implications

Alcohol (1992)

Pratima Murthy S.C. Guru K. Taranath Shetty Rajat Ray S. M. Channabasavanna

Disulfiram

Chlordiazepoxide

10.1016/0741-8329(92)90053-d

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Citations (3)

Hypocalcitonemia in Handigodu Disease: a spondylo epi (meta) physeal dysplasia.

PubMed (2010)

Mallikarjun Badadani K. Taranath Shetty SS Agarwal

Handigodu Disease (HD) is a disorder of the osteoarticular system which is highly prevalent in several villages of two districts viz, Shimoga and Chikmaglur of the state of Karnataka, southern India. The scientific name of the disease is Spondylo-epi-(meta) physeal Dysplasia, Autosomal Dominant variety, Handigodu syndrome. The same has been listed in the International Classification of Skeletal Dysplasias. The calcium homeostasis study was lack in HD. The serum calcium, phosphorus, parathyroid hormone and calcitonin levels after overnight fast state, and 24 hour urinary excretion of calcium and phosphorus were quantified. The decreased level of calcitonin associated with decreased serum total calcium and urinary calcium in HD were observed. The levels of parathyroid hormone, serum phosphorus and urinary phosphorus remain unchanged among HD affected. The Vitamin D3 levels also noticed unchanged in HD affected. Since calcitonin has antiresorption effect on bone, the observed low calcitonin in HD may imply reosrption of bone leading to deformity and causes hypocalcaemia and hypocalciuria. The hypocalcitonemia without change in iPTH associated with hypocalcaemia may be a mutation in Vit D receptor (VDR) or may be an epiphenomenon.

Hypocalcaemia

Hypocalciuria

Urinary calcium

Hypophosphatemia

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Citations (3)